(R)-Flurbiprofen - ≥99%, high purity , Gamma-secretase modulator, CAS No.51543-40-9, Gamma-secretase modulator

Item Number

F275360

• Synonyms: ISCK-03 | (R)-(-)-2-Fluoro-a-methyl-4-biphenylacetic acid | AS-44113 | NCGC00018157-07 | CHEBI:38666 | (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid | (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid, 97% | Flurbiprofen (Ansaid) | (R)-2-(2-Fluoro-[1,1'-
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: γ-secretase inhibitor. Flurbiprofen enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects in vivo.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: MODULATOR
• Mechanism of action: Gamma-secretase modulator
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.