Basic Description

Synonyms	Tarenflurbil\|51543-40-9\|Flurizan\|(R)-Flurbiprofen\|R-Flurbiprofen\|(R)-2-Flurbiprofen\|(R)-2-Flubiprofen\|MPC-7869\|(R)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid\|(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid\|Flurbiprofen, (r)-\|(2r)-2-(3-Fluoro-4-Phenyl-
Specifications & Purity	≥99%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Dry ice
Action Type	MODULATOR
Mechanism of action	Gamma-secretase modulator
Product Description	Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.

Product Properties

ALogP	4.2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Pubchem Sid	488186703
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488186703
IUPAC Name	(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid
INCHI	InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
InChi Key	SYTBZMRGLBWNTM-SNVBAGLBSA-N
Canonical SMILES	CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Isomeric SMILES	C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
PubChem CID	92337
Molecular Weight	244.26

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6 results found

Lot Number	Certificate Type	Date	Item
E2317614	Certificate of Analysis	Mar 22, 2024	F275360
E2317651	Certificate of Analysis	Mar 22, 2024	F275360
E2317667	Certificate of Analysis	Mar 22, 2024	F275360
E2317615	Certificate of Analysis	Mar 07, 2024	F275360
E2317613	Certificate of Analysis	Mar 07, 2024	F275360
E2317612	Certificate of Analysis	Mar 07, 2024	F275360

Solubility	Soluble in ethanol to 100 mM and in DMSO to 25 mM

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.

1. Green RC, Schneider LS, Amato DA, Beelen AP, Wilcock G, Swabb EA, Zavitz KH, Tarenflurbil Phase 3 Study Group. (2009) Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial.. JAMA, 302 (23): (2557-64). [PMID:20009055]
2. Xia W, Wong ST, Hanlon E, Morin P. (2012) γ-Secretase modulator in Alzheimer's disease: shifting the end.. J Alzheimers Dis, 31 (4): (685-96). [PMID:22710916]

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

SKU	Size	Availability	Price
F275360-25mg	25mg	In stock	$17.90
F275360-100mg	100mg	In stock	$58.90
F275360-500mg	500mg	In stock	$265.90