(R)-Lisofylline - 98%, high purity , CAS No.100324-81-0

Item Number

R341807

Grouped product items
SKU	Size	Availability	Price
R341807-2mg	2mg	In stock	$332.90
R341807-5mg	5mg	In stock	$692.90
R341807-10mg	10mg	In stock	$1,137.90
R341807-25mg	25mg	In stock	$2,276.90
R341807-50mg	50mg	In stock	$3,612.90

an immunomodulator and metabolite of Pentoxifyline, it inhibits phosphatidic acid production

Basic Description

Synonyms	(R)-Lisofylline\|LISOFYLLINE\|100324-81-0\|ProTec\|CT 1501R\|CT-1501R\|Lisophylline\|1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione\|Lisofylline, (r)-\|1-[(R)-5-hydroxyhexyl]theobromine\|(R)-Lisophylline\|3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-pur
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	(R)-Lisofylline is an immunomodulator and a major metabolite of Pentoxifylline and Methylxanthine. (R)-Lisofylline inhibits production of phosphatidic acid during the inflammatory response.

Names and Identifiers

IUPAC Name	1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione
INCHI	InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1
InChi Key	NSMXQKNUPPXBRG-SECBINFHSA-N
Canonical SMILES	CC(CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C)O
Isomeric SMILES	C[C@H](CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C)O
PubChem CID	501254
Molecular Weight	280.32

PubChem CID

ChEMBL Ligand

CAS Registry No.

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5 results found

Lot Number	Certificate Type	Date	Item
C2301297	Certificate of Analysis	Sep 08, 2022	R341807
C2301298	Certificate of Analysis	Sep 08, 2022	R341807
C2301299	Certificate of Analysis	Sep 08, 2022	R341807
C2301302	Certificate of Analysis	Sep 08, 2022	R341807
C2301317	Certificate of Analysis	Sep 08, 2022	R341807

Chemical and Physical Properties

Solubility	Soluble in ethanol (~25 mg/ml), DMSO (~20 mg/ml), DMF (~15 mg/ml), chloroform, and methanol.
Sensitivity	Moisture sensitive
Refractive Index	n20D1.62 (Predicted)
Specific Rotation[α]	α20/D -6.26°, c = 1 in methanol
Boil Point(°C)	511.2° C at 760 mmHg (Predicted)
Melt Point(°C)	105-107° C

References

1. Yang Z, Chen M, Carter JD, Nunemaker CS, Garmey JC, Kimble SD, Nadler JL. (2006) Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes.. Biochem Biophys Res Commun, 344 (3): (1017-22). [PMID:16643856]
2. Cui P, Macdonald TL, Chen M, Nadler JL. (2006) Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes.. Bioorg Med Chem Lett, 16 (13): (3401-5). [PMID:16650991]
3. Tersey SA, Carter JD, Rosenberg L, Taylor-Fishwick DA, Mirmira RG, Nadler JL. (2012) Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.. J Diabetes Mellitus, 2 (2): (251-257). [PMID:26473085]
4. Rice GC, Rosen J, Weeks R, Michnick J, Bursten S, Bianco JA, Singer JW. (1994) CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo.. Shock, 1 (4): (254-66). [PMID:7735959]

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Basic Description