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(R)-(-)-Rolipram - ≥97.0%, high purity , CAS No.85416-75-7

≥97%

CAS#: 85416-75-7
Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.35
MDL number: MFCD03093861
PubChem CID: 448055

Item Number

R160943

Grouped product items
SKU	Size	Availability	Price	Qty
R160943-10mg	10mg	In stock	$118.90
R160943-50mg	50mg	In stock	$423.90

Discover (R)-(-)-Rolipram by Aladdin Scientific in ≥97.0% for only $118.90. Available - in Ligands at Aladdin Scientific. Selective PDE4 inhibitor Tags: Pharmaceutical ingredients.

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Pharmaceutical ingredients

Basic Description

Synonyms	(R)-(-)-Rolipram\|85416-75-7\|(R)-ROLIPRAM\|(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one\|(-)-ROLIPRAM\|(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE\|R-Rolipram\|Rolipram, (-)-\|(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-on
Specifications & Purity	≥97.0%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.

Associated Targets

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 2 Activities

Discover Target: PDE4D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 3 Activities

Discover Target: PDE4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4B 7 Activities

Discover Target: PDE4B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
INCHI	InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
InChi Key	HJORMJIFDVBMOB-LBPRGKRZSA-N
Canonical SMILES	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
Isomeric SMILES	COC1=C(C=C(C=C1)[C@H]2CC(=O)NC2)OC3CCCC3
PubChem CID	448055
Molecular Weight	275.35
Reaxy-Rn	5442919

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2 results found

Lot Number	Certificate Type	Date	Item
G2203417	Certificate of Analysis	Jun 11, 2022	R160943
G2203418	Certificate of Analysis	Jun 11, 2022	R160943

Sensitivity

Heat Sensitive

Specific Rotation[α]

-32° (C=0.5,MeOH)

Melt Point(°C)

134 °C

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