(R,S)-AMPA - ≥99%, high purity , CAS No.74341-63-2

  • ≥99%
Item Number
A275535
Grouped product items
SKUSizeAvailabilityPrice Qty
A275535-10mM-ml
10mM/ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$120.90

AMPA agonist. 1 ml water soluble pack.

Basic Description

SynonymsGTPL4077 | (+/-)-alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID | (R)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid | .GAMMA.-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID | AMPA, D,L- | (+/-)-.ALPHA.-AMINO-3-HYDROXY-5-METHYL-
Specifications & Purity≥99%
Biochemical and Physiological MechanismsPrototypic agonist for AMPA receptors. Soluble in 1 ml water to give specified mM/ml concentration.
Storage TempRoom temperature
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. The product can be stored for up to 12 months.

Associated Targets(Human)

GRIA4 Tclin Glutamate receptor 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIK1 Tclin Glutamate receptor ionotropic, kainate 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA2 Tclin Glutamate receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA3 Tclin Glutamate receptor 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA1 Tclin Glutamate receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grik2 Glutamate receptor ionotropic kainate 2 (298 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc1a2 Excitatory amino acid transporter 2 (39 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA (2103 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grik1 Glutamate receptor ionotropic, kainate (722 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor AMPA 1/2 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
INCHI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
InChi Key UUDAMDVQRQNNHZ-UHFFFAOYSA-N
Canonical SMILES CC1=C(C(=O)NO1)CC(C(=O)O)N
Isomeric SMILES CC1=C(C(=O)NO1)CC(C(=O)O)N
PubChem CID 1221
Molecular Weight 186.17

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

SolubilitySoluble in 1 ml water to give specified mM/ml concentration

Related Documents

Citations of This Product

1. LuLu Cao, Yunlei Zhou, Lanlan Gao, Huanshun Yin, Miao Zhang, Haowei Zhang, Peng Ju, Kunpeng Dou, Shiyun Ai.  (2023)  Ascorbic Acid Induced the Improved Oxygen Vacancy Defects of Bi4O5Br2 and Its Application on Photoelectrochemical Detection of DNA Demethylase MBD2 with Improved Detection Sensitivity.  Small,    (27): (2306365).  [PMID:38009777] [10.1002/smll.202306365]
2. Huadong Tan, Qiao Xing, Ling Mo, Chunyuan Wu, Xiaoying Zhang, Xiaoyu He, Yuefu Liang, Rong Hao.  (2024)  Occurrence, multiphase partitioning, drivers, and ecological risks of current-use herbicides in a river basin dominated by rice–vegetable rotations in tropical China.  SCIENCE OF THE TOTAL ENVIRONMENT,  908  (15): (168270).  [PMID:37918751] [10.1016/j.scitotenv.2023.168270]
3. Yingping Huang, Zhangli Li, Kun Yao, Chuncheng Chen, Chaoyuan Deng, Yanfen Fang, Ruiping Li, Hailin Tian.  (2021)  Suppressing toxic intermediates during photocatalytic degradation of glyphosate by controlling adsorption modes.  APPLIED CATALYSIS B-ENVIRONMENTAL,  299  (120671).  [PMID:] [10.1016/j.apcatb.2021.120671]
4. Jia Ding, Wenjing Jiang, Yunlei Zhou, Huanshun Yin, Shiyun Ai.  (2020)  Electrochemiluminescence immunosensor for 5-hydroxymethylcytosine detection based on PAMAM-nanosilver‑nitrogen doped graphene nanocomposite.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,  877  (114646).  [PMID:] [10.1016/j.jelechem.2020.114646]
5. Zhang Chao, She Yongxin, Li Tengfei, Zhao Fengnian, Jin Maojun, Guo Yirong, Zheng Lufei, Wang Shanshan, Jin Fen, Shao Hua, Liu Haijin, Wang Jing.  (2017)  A highly selective electrochemical sensor based on molecularly imprinted polypyrrole-modified gold electrode for the determination of glyphosate in cucumber and tap water.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (30): (7133-7144).  [PMID:29018930] [10.1007/s00216-017-0671-5]
6. Bo Xing, Honglin Chen, Xiaoming Zhang.  (2018)  Efficient degradation of organic phosphorus in glyphosate wastewater by catalytic wet oxidation using modified activated carbon as a catalyst.  ENVIRONMENTAL TECHNOLOGY,  39  (6): (749-758).  [PMID:28332926] [10.1080/09593330.2017.1310935]
7. Yaqing Chang, Zhe Zhang, Jinhui Hao, Wenshu Yang, Jilin Tang.  (2016)  A simple label free colorimetric method for glyphosate detection based on the inhibition of peroxidase-like activity of Cu(Ⅱ).  SENSORS AND ACTUATORS B-CHEMICAL,  228  (410).  [PMID:] [10.1016/j.snb.2016.01.048]

References

1. LuLu Cao, Yunlei Zhou, Lanlan Gao, Huanshun Yin, Miao Zhang, Haowei Zhang, Peng Ju, Kunpeng Dou, Shiyun Ai.  (2023)  Ascorbic Acid Induced the Improved Oxygen Vacancy Defects of Bi4O5Br2 and Its Application on Photoelectrochemical Detection of DNA Demethylase MBD2 with Improved Detection Sensitivity.  Small,    (27): (2306365).  [PMID:38009777] [10.1002/smll.202306365]
2. Huadong Tan, Qiao Xing, Ling Mo, Chunyuan Wu, Xiaoying Zhang, Xiaoyu He, Yuefu Liang, Rong Hao.  (2024)  Occurrence, multiphase partitioning, drivers, and ecological risks of current-use herbicides in a river basin dominated by rice–vegetable rotations in tropical China.  SCIENCE OF THE TOTAL ENVIRONMENT,  908  (15): (168270).  [PMID:37918751] [10.1016/j.scitotenv.2023.168270]
3. Yingping Huang, Zhangli Li, Kun Yao, Chuncheng Chen, Chaoyuan Deng, Yanfen Fang, Ruiping Li, Hailin Tian.  (2021)  Suppressing toxic intermediates during photocatalytic degradation of glyphosate by controlling adsorption modes.  APPLIED CATALYSIS B-ENVIRONMENTAL,  299  (120671).  [PMID:] [10.1016/j.apcatb.2021.120671]
4. Jia Ding, Wenjing Jiang, Yunlei Zhou, Huanshun Yin, Shiyun Ai.  (2020)  Electrochemiluminescence immunosensor for 5-hydroxymethylcytosine detection based on PAMAM-nanosilver‑nitrogen doped graphene nanocomposite.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,  877  (114646).  [PMID:] [10.1016/j.jelechem.2020.114646]
5. Zhang Chao, She Yongxin, Li Tengfei, Zhao Fengnian, Jin Maojun, Guo Yirong, Zheng Lufei, Wang Shanshan, Jin Fen, Shao Hua, Liu Haijin, Wang Jing.  (2017)  A highly selective electrochemical sensor based on molecularly imprinted polypyrrole-modified gold electrode for the determination of glyphosate in cucumber and tap water.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (30): (7133-7144).  [PMID:29018930] [10.1007/s00216-017-0671-5]
6. Bo Xing, Honglin Chen, Xiaoming Zhang.  (2018)  Efficient degradation of organic phosphorus in glyphosate wastewater by catalytic wet oxidation using modified activated carbon as a catalyst.  ENVIRONMENTAL TECHNOLOGY,  39  (6): (749-758).  [PMID:28332926] [10.1080/09593330.2017.1310935]
7. Yaqing Chang, Zhe Zhang, Jinhui Hao, Wenshu Yang, Jilin Tang.  (2016)  A simple label free colorimetric method for glyphosate detection based on the inhibition of peroxidase-like activity of Cu(Ⅱ).  SENSORS AND ACTUATORS B-CHEMICAL,  228  (410).  [PMID:] [10.1016/j.snb.2016.01.048]

Solution Calculators