R547 - ≥98%, high purity , Cyclin-dependent kinase 4 inhibitor, CAS No.741713-40-6, Cyclin-dependent kinase 4 inhibitor

Item Number

R127351

• Synonyms: (4-amino-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone | (4-Amino-2-{[1-(Methylsulfonyl)piperidin-4-Yl]amino}pyrimidin-5-Yl)(2,3-Difluoro-6-Methoxyphenyl)methanone | R 547 | Ro 4584820 | SMR004701352 | NSC
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent and selective CDK inhibitor (Kivalues are 1, 2, 3, 46, 171 and 260 nM for CDK4/cyclin D1, CDK1/cyclin B, CDK2/cyclin E, GSK3α, CDK7/cyclin H and GSK3β). Exhibits no effect against a panel of >120 other kinases (Ki> 5,000 nM). Inhibits the prolifera
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Cyclin-dependent kinase 4 inhibitor

Product Description

R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
A selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4.