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RA 839 - ≥98%(HPLC), high purity , CAS No.1832713-02-6, kelch like ECH-associated protein 1

  • Moligand™
  • ≥98%(HPLC)
Item Number
R286798
Grouped product items
SKUSizeAvailabilityPrice Qty
R286798-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$62.90
R286798-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
R286798-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$204.90
R286798-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$327.90
R286798-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$523.90
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Nrf2 activator; inhibits Nrf2/Keap1 interaction

View related series
kelch like ECH-associated protein 1

Basic Description

Synonyms(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
Specifications & Purity≥98%(HPLC)
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Mechanism of actionkelch like ECH-associated protein 1
Product Description

Product description

RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.

Associated Targets

KEAP1 Tclin Kelch-like ECH-associated protein 1 6 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (3S)-1-[4-[(2,3,5,6-tetramethylphenyl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acid
INCHI InChI=1S/C25H28N2O4S/c1-15-13-16(2)18(4)24(17(15)3)32(30,31)26-22-9-10-23(21-8-6-5-7-20(21)22)27-12-11-19(14-27)25(28)29/h5-10,13,19,26H,11-12,14H2,1-4H3,(H,28,29)/t19-/m0/s1
InChi Key BVYWIQHJXAEJOD-IBGZPJMESA-N
Canonical SMILES CC1=CC(=C(C(=C1C)S(=O)(=O)NC2=CC=C(C3=CC=CC=C32)N4CCC(C4)C(=O)O)C)C
Isomeric SMILES CC1=CC(=C(C(=C1C)S(=O)(=O)NC2=CC=C(C3=CC=CC=C32)N4CC[C@@H](C4)C(=O)O)C)C
PubChem CID 91971266
Molecular Weight 452.57

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Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
B2427267Certificate of AnalysisJan 20, 2024 R286798
B2427268Certificate of AnalysisJan 20, 2024 R286798
B2427269Certificate of AnalysisJan 20, 2024 R286798
B2427270Certificate of AnalysisJan 20, 2024 R286798
B2427271Certificate of AnalysisJan 20, 2024 R286798
B2427272Certificate of AnalysisJan 20, 2024 R286798
B2427273Certificate of AnalysisJan 20, 2024 R286798
B2427274Certificate of AnalysisJan 20, 2024 R286798
B2427275Certificate of AnalysisJan 20, 2024 R286798
B2427276Certificate of AnalysisJan 20, 2024 R286798

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 45.26, Max Conc. mM: 100
Sensitivitylight sensitive

Related Documents

 SDS

 Specification Sheet

References

1. Winkel AF, Engel CK, Margerie D, Kannt A, Szillat H, Glombik H, Kallus C, Ruf S, Güssregen S, Riedel J et al..  (2015)  Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling..  J Biol Chem,  290  (47): (28446-55).  [PMID:26459563]
2. Patra U, Mukhopadhyay U, Sarkar R, Mukherjee A, Chawla-Sarkar M.  (2019)  RA-839, a selective agonist of Nrf2/ARE pathway, exerts potent anti-rotaviral efficacy in vitro..  Antiviral Res,  161  (3): (53-62).  [PMID:30465784]

Solution Calculators

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