Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R126180-250mg | 250mg | In stock | $34.90 | |
R126180-1g | 1g | In stock | $114.90 | |
R126180-5g | 5g | In stock | $517.90 | |
R126180-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,328.90 |
Potent enkephalinase inhibitor
Synonyms | Racecadotril | 81110-73-8 | Acetorphan | Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate | Hidrasec | Tiorfan | Racecadotril [INN] | Tiorfix | MFCD00865520 | NSC-759828 | benzyl (3-(acetylthio)-2-benzylpropanoyl)glycinate | 76K53XP4TO | Racecadotril (INN) | benzyl 2-[[2-(acet |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Racecadotril is a potent CD10 (enkephalinase) inhibitor which exhibits selective antisecretory activity.Potent enkephalinase inhibitor (IC 50 = 5 nM). Inhibits pathologic (but not basal) secretion from the gut. Shows blood-glucose lowering and central ana |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Neprilysin inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM. |
ALogP | 3.3 |
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Pubchem Sid | 488187417 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187417 |
IUPAC Name | benzyl 2-[[2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate |
INCHI | InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25) |
InChi Key | ODUOJXZPIYUATO-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2 |
Isomeric SMILES | CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2 |
WGK Germany | 3 |
Alternate CAS | 81110-73-8 |
PubChem CID | 107751 |
NSC Number | 759828 |
MeSH Entry Terms | acetorphan;acetorphan, (R)-isomer;acetorphan, (S)-isomer;ecadotril;N-(3-acetylmercapto-2-benzylpropanoyl)glycine benzyl ester;racecadotril;retorphan;sinorphan |
Molecular Weight | 385.48 |
PubChem CID | 107751 |
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CAS Registry No. | 81110-73-8 |
PubChem SID | 488187417 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F1508142 | Certificate of Analysis | Jan 25, 2023 | R126180 |
D23261193 | Certificate of Analysis | Jun 09, 2022 | R126180 |
F2204912 | Certificate of Analysis | Jun 09, 2022 | R126180 |
F2204913 | Certificate of Analysis | Jun 09, 2022 | R126180 |
F2204979 | Certificate of Analysis | Jun 09, 2022 | R126180 |
Solubility | Soluble in ethanol (77 mg/ml at 25 °C), DMSO (≥44 mg/ml), and water (<1 mg/ml at 25 °C). |
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Melt Point(°C) | 89 °C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H400:Very toxic to aquatic life |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
Merck Index | 8090 |
1. Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F. (1986) In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF.. Eur J Pharmacol, 125 (1): (147-50). [PMID:3015640] |