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SKU | Size | Availability | Price | Qty |
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R649900-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $70.90 | |
R649900-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $110.90 | |
R649900-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $220.90 | |
R649900-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $360.90 | |
R649900-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $580.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | RAD51-IN-1, a derivative of xa0B02, is a potent inhibitor of RAD51 . RAD51-IN-1 can be used for cancer research. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | RAD51-IN-1, a derivative of B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research. In Vitro RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple-negative breast cancer (TNBC). RAD51-IN-1 (10 μM) decreases the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation. RAD51-IN-1 (10 μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
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IUPAC Name | 3-[(4-chlorophenyl)methyl]-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one |
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INCHI | InChI=1S/C22H16ClN3O/c23-18-10-7-17(8-11-18)15-26-21(12-9-16-4-3-13-24-14-16)25-20-6-2-1-5-19(20)22(26)27/h1-14H,15H2/b12-9+ |
InChi Key | AQNDWTVLZSMOQU-FMIVXFBMSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=O)N(C(=N2)C=CC3=CN=CC=C3)CC4=CC=C(C=C4)Cl |
Isomeric SMILES | C1=CC=C2C(=C1)C(=O)N(C(=N2)/C=C/C3=CN=CC=C3)CC4=CC=C(C=C4)Cl |
PubChem CID | 53245568 |
Molecular Weight | 373.8 |
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Solubility | DMSO : 62.5 mg/mL (167.19 mM; Need ultrasonic) |
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