Basic Description

Synonyms	Radezolid \| 869884-78-6 \| RX-1741 \| RX-103 \| N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide \| rx103 \| RX-01_667 \| 53PC6LO35W \| MMV688327 \| RX-013 \| RX1741 \| (S)-N-((3-(4'-((((1H-1,2,3-triazol-5-yl
Specifications & Purity	Moligand™, ≥96%
Biochemical and Physiological Mechanisms	Radezolid (INN, codenamed RX-1741) is a novel oxazolidinone antibiotic being developed by Rib-X Pharmaceuticals, Inc. for the treatment of serious multi-drug–resistant infections. Radezolid has completed two phase-II clinical trials
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Bacterial 70S ribosome inhibitor

Product Properties

ALogP	1.1

Associated Targets(Human)

THP-1 (11052 Activities)

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HUVEC (11049 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Streptococcus (3973 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Chlamydia pneumoniae (241 Activities)

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Legionella pneumophila (143 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Staphylococcus hominis (482 Activities)

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Moraxella catarrhalis (3334 Activities)

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Haemophilus influenzae (8812 Activities)

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Chlamydia trachomatis (699 Activities)

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Staphylococcus (1598 Activities)

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Streptococcus pyogenes (16140 Activities)

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Enterococcus faecium (13803 Activities)

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Listeria monocytogenes (2626 Activities)

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Mycoplasmoides pneumoniae (351 Activities)

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Enterococcus faecalis (29875 Activities)

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Staphylococcus capitis (242 Activities)

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J774 (3120 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Metamycoplasma hominis (88 Activities)

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-[[(5S)-3-[3-fluoro-4-[4-[(2H-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
INCHI	InChI=1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1
InChi Key	BTTNOGHPGJANSW-IBGZPJMESA-N
Canonical SMILES	CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
Isomeric SMILES	CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
PubChem CID	11224409
Molecular Weight	438.45

Database links

CAS Registry No.	869884-78-6
PubChem CID	11224409
ChEMBL Ligand	CHEMBL455461
DrugBank Ligand	DB12339
RCSB PDB Ligand	RD8
Antibiotic DB	166, 820

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	DMSO

References

1. Lawrence L, Danese P, DeVito J, Franceschi F, Sutcliffe J. (2008) In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.. Antimicrob Agents Chemother, 52 (5): (1653-62). [PMID:18316525]
2. Skripkin E, McConnell TS, DeVito J, Lawrence L, Ippolito JA, Duffy EM, Sutcliffe J, Franceschi F. (2008) R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance.. Antimicrob Agents Chemother, 52 (10): (3550-7). [PMID:18663023]

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SKU	Size	Availability	Price
R126228-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$897.90
R126228-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,476.90
R126228-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,689.90

Radezolid - ≥96%, high purity , Bacterial 70S ribosome inhibitor, CAS No.869884-78-6, Bacterial 70S ribosome inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator