Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R129802-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $75.90 | |
R129802-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $129.90 | |
R129802-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $380.90 | |
R129802-250mg | 250mg | In stock | $1,714.90 | |
R129802-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $6,172.90 |
Potent HIV-1 integrase inhibitor
Synonyms | Raltegravir | 518048-05-0 | MK-0518 | Isentress | Raltegravir (MK-0518) | MK0518 | raltegravirum | Raltegravir (INN) | UNII-22VKV8053U | MK 0518 | DTXSID2048660 | N-(2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4 |
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Specifications & Purity | ≥97% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively. |
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IUPAC Name | N-[2-[4-[(4-fluorophenyl)methylcarbamoyl]-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide |
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INCHI | InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30) |
InChi Key | CZFFBEXEKNGXKS-UHFFFAOYSA-N |
Canonical SMILES | CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F |
Isomeric SMILES | CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F |
PubChem CID | 54671008 |
Molecular Weight | 444.42 |
PubChem CID | 54671008 |
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CAS Registry No. | 518048-05-0 |
ChEMBL Ligand | CHEMBL254316 |
BindingDB Ligand | 25351 |
DrugBank Ligand | DB06817 |
RCSB PDB Ligand | RLT |
Enter Lot Number to search for COA:
Solubility | DMSO 89 mg/mL Water Ethanol |
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1. Rowley M. (2008) The discovery of raltegravir, an integrase inhibitor for the treatment of HIV infection.. Prog Med Chem, 46 (3): (1-28). [PMID:18381123] |