Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R129247-100mg | 100mg | In stock | $64.90 | |
R129247-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $97.90 | |
R129247-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $176.90 | |
R129247-5g | 5g | In stock | $793.90 | |
R129247-25g | 25g | In stock | $3,572.90 |
Potent ACE inhibitor
Synonyms | KBioSS_002512 | Naprix | Ramipril (USAN:USP:INN:BAN) | SCHEMBL16059 | Tetramethylthiuramonosulfide | (2S,3aS,6aS)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid | (2S,3As,6aS)-1-[(2S)-2-[[( |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Ramipril is an inhibitor of the ACE (angiotensin- converting enzyme) that is reported to quickly hydrolyze into the active metabolite Ramiprilat. Studies indicate that Ramipril is a more potent inhibitor in comparison to Zofenopril. Acute coronary syndrom |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Angiotensin-converting enzyme |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
ALogP | 1.4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid |
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INCHI | InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1 |
InChi Key | HDACQVRGBOVJII-JBDAPHQKSA-N |
Canonical SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(=O)O |
Isomeric SMILES | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O |
WGK Germany | 2 |
RTECS | GY5879600 |
Alternate CAS | 87333-19-5 |
PubChem CID | 5362129 |
NSC Number | 758933 |
MeSH Entry Terms | Acovil;Altace;Carasel;Delix;HOE 498;HOE-498;HOE498;Ramace;Ramipril;Triatec;Tritace;Vesdil;Zabien |
Molecular Weight | 416.51 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K1813110 | Certificate of Analysis | Apr 10, 2024 | R129247 |
K1813109 | Certificate of Analysis | Apr 07, 2024 | R129247 |
B2223459 | Certificate of Analysis | Dec 20, 2023 | R129247 |
B2223509 | Certificate of Analysis | Dec 20, 2023 | R129247 |
Solubility | Soluble in water (<1 mg/ml at 25 °C), DMSO (83 mg/ml at 25 °C), methanol, Aqueous Alkali, and ethanol (83 mg/ml at 25 °C). |
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Sensitivity | Heat Sensitive |
Specific Rotation[α] | 40° (C=1,0.1 NHCl in EtOH) |
Melt Point(°C) | 109 °C |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H360:May damage fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 2 |
RTECS | GY5879600 |
Merck Index | 8103 |
1. Liu K, Zhao X, Qi X, Hou DL, Li HB, Gu YH, Xu QL.. (2021) Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.. Eur J Med Chem, 218 (113388-113388). [PMID:33784603] [10.1016/j.ejmech.2021.113388] |
1. Liu K, Zhao X, Qi X, Hou DL, Li HB, Gu YH, Xu QL.. (2021) Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.. Eur J Med Chem, 218 (113388-113388). [PMID:33784603] [10.1016/j.ejmech.2021.113388] |