Basic Description

Product Name	Ramucirumab (anti-VEGFR2), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to VEGFR2, >95%, high purity, Human IgG1
Synonyms	EC 2.7.10.1 \| Fetal liver kinase 1 \| FLK-1 \| KDR \| Kinase insert domain receptor \| Protein-tyrosine kinase receptor flk-1 \| VEGFR-2
Specifications & Purity	ExactAb™, Validated, Carrier Free, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	VEGFR2
Application	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of kinase insert domain receptor
Product Description	Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. It is also an angiogenesis inhibitor. Purity>95% (SDS-PAGE&SEC) Endotoxin Level< 0.01EU/μg

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Human IgG1
SDS-PAGE	26.5 kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 176.7 kDa, under non-reducing conditions
Purification Method	Protein A purified
Purity	>95%
Source	CHO supernatant
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	947687-13-0

Images

Ramucirumab (anti-VEGFR2) (R411995) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling VEGFR2 (red) with Ramucirumab (anti-VEGFR2) (R411995). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Ramucirumab (anti-VEGFR2) (R411995) - SEC
The purity of Ramucirumab (anti-VEGFR2) (R411995) is more than 95% verified by HPLC.

Associated Targets(Human)

KDR Tclin Vascular endothelial growth factor receptor 2 (0 Activities)

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin VEGF-receptor 2 and Fibroblast growth factor receptor 2 (15 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin VEGF-receptor 2 and Fibroblast growth factor receptor 1 (50 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) (14 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin TEL/KDR (9 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin VHL/Vascular endothelial growth factor receptor 2 (56 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Database links

IMGT/mAb-DB	295
Wikipedia	Ramucirumab

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0303069	Certificate of Analysis	Mar 08, 2024	R411995
ZJ24F0303068	Certificate of Analysis	Mar 08, 2024	R411995
ZJ24F0303067	Certificate of Analysis	Mar 08, 2024	R411995

References

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SKU	Size	Availability	Price
R411995-100μg	100μg	In stock	$39.90
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R411995-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,196.90

Ramucirumab (anti-VEGFR2), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to VEGFR2, >95%, high purity, Human IgG1, Antibody of kinase insert domain receptor

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