RAP1 Antibody - Primary antibody, specific to TERF2IP, Rabbit IgG

    Application:
  • IHC
  • WB
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab124571
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab124571-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
Ab124571-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$149.90
Ab124571-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
Ab124571-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,999.90

pAb; Rabbit anti Human RAP1 Antibody; WB, IHC; Unconjugated

Basic Description

Product NameRAP1 Antibody - Primary antibody, specific to TERF2IP, Rabbit IgG
SynonymsDopamine receptor interacting protein 5 antibody | Dopamine receptor-interacting protein 5 antibody | DRIP 5 antibody | DRIP5 antibody | hRap1 antibody | MGC105533 antibody | RAP 1 antibody | RAP1 homolog antibody | RAP1, yeast, homolog if antibody | RAP1
Specifications & PurityValidated, 1.0 mg/mL
Host speciesRabbit
SpecificityTERF2IP
ImmunogenA synthetic peptide derived from human RAP1 (AA 203-252)
Positive ControlWB: HEK293 and Hep G2 cell lysates. IHC: human Gastric adenocarcinoma tissue.
ConjugationUnconjugated
GradeValidated
Product Description

Rabbit anti Human RAP1 Antibody, Polyclonal, could be used for WB, IHC and so on.
Application:
WB: 1/500-1/2000
IHC: 1/50-1/300
Protein Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodImmunogen affinity purified
FormLiquid
Concentration1.0 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -20°C long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

RAP1 Antibody (Ab124571) - Western Blot
All lanes: RAP1 Antibody (Ab124571) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 44 kDa
Observed band size: 57 kDa
Exposure time: 120.0 s 

RAP1 Antibody (Ab124571) - IHC
Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma.
1. RAP1 Antibody (Ab124571) was diluted at 1/200 (4℃, overnight)
2. Tris-EDTA, pH 9.0 was used for antigen retrieval
3. Secondary antibody was diluted at 1/200 (room temperature, 45 min).

Associated Targets(Human)

TERF2IP Tchem Telomeric repeat-binding factor 2-interacting protein 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Application

ApplicationDilution info
WB1/500-1/2000

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1/500-1/2000

IHC 1/50-1/300

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1/50-1/300

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0708240Certificate of AnalysisJul 12, 2024 Ab124571
ZJ24F0708241Certificate of AnalysisJul 12, 2024 Ab124571

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