Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S115842-10mg | 10mg | In stock | $15.90 | |
S115842-25mg | 25mg | In stock | $29.90 | |
S115842-50mg | 50mg | In stock | $39.90 | |
S115842-250mg | 250mg | In stock | $119.90 | |
S115842-1g | 1g | In stock | $339.90 |
mTORC1 complex inhibitor
Synonyms | AY 22989 | AY-22989 | CHEBI:9168 | EC 610-965-5 | HMS2089A21 | RAPA | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl |
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Specifications & Purity | ≥98%(HPLC) |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Rapamycin is an anti-fungal antibiotic isolated from Streptomyces hygroscopicus. This antibiotic is active against all strains of Candida albicans. It blocks the signal transduction pathways required for the activation of T-helper cells. |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 488195295 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195295 |
IUPAC Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
INCHI | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 |
InChi Key | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
Canonical SMILES | CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC |
Isomeric SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC |
RTECS | VE6250000 |
Molecular Weight | 914.19 |
Reaxy-Rn | 5848501 |
PubChem SID | 488195295 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2228737 | Certificate of Analysis | Sep 04, 2024 | S115842 |
H2428321 | Certificate of Analysis | Jul 24, 2024 | S115842 |
H2428320 | Certificate of Analysis | Jul 24, 2024 | S115842 |
H2428319 | Certificate of Analysis | Jul 24, 2024 | S115842 |
H2428300 | Certificate of Analysis | Jul 24, 2024 | S115842 |
H2428322 | Certificate of Analysis | Jul 24, 2024 | S115842 |
E2421478 | Certificate of Analysis | Apr 10, 2024 | S115842 |
E2421163 | Certificate of Analysis | Apr 10, 2024 | S115842 |
E2421162 | Certificate of Analysis | Apr 10, 2024 | S115842 |
E2421161 | Certificate of Analysis | Apr 10, 2024 | S115842 |
E2421160 | Certificate of Analysis | Apr 10, 2024 | S115842 |
G2326291 | Certificate of Analysis | Jul 08, 2023 | S115842 |
G2326288 | Certificate of Analysis | Jul 08, 2023 | S115842 |
G2326284 | Certificate of Analysis | Jul 08, 2023 | S115842 |
G2326272 | Certificate of Analysis | Jul 08, 2023 | S115842 |
G2326282 | Certificate of Analysis | Jul 08, 2023 | S115842 |
E2305104 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305219 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305193 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305202 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305205 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305212 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305213 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305215 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305216 | Certificate of Analysis | Feb 22, 2023 | S115842 |
E2305217 | Certificate of Analysis | Feb 22, 2023 | S115842 |
K2228734 | Certificate of Analysis | Oct 14, 2022 | S115842 |
K2228735 | Certificate of Analysis | Oct 14, 2022 | S115842 |
K2228736 | Certificate of Analysis | Oct 14, 2022 | S115842 |
K2228738 | Certificate of Analysis | Oct 14, 2022 | S115842 |
H2230023 | Certificate of Analysis | Sep 03, 2022 | S115842 |
J2215165 | Certificate of Analysis | Jun 11, 2022 | S115842 |
K2218143 | Certificate of Analysis | Jun 11, 2022 | S115842 |
G2227355 | Certificate of Analysis | Jun 11, 2022 | S115842 |
G2227354 | Certificate of Analysis | Jun 11, 2022 | S115842 |
G2227353 | Certificate of Analysis | Jun 11, 2022 | S115842 |
G2227352 | Certificate of Analysis | Jun 11, 2022 | S115842 |
D2009140 | Certificate of Analysis | Feb 17, 2022 | S115842 |
Solubility | Insoluble in water; Soluble in Chloroform,Acetone,Dimethylformamide,Methanol,Ether |
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Sensitivity | Heat sensitive. |
Specific Rotation[α] | -150° (C=0.2,MeOH) |
Melt Point(°C) | 177 °C(dec.) |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
RTECS | VE6250000 |
Reaxy-Rn | 5848501 |
Merck Index | 8114 |
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1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang. (2023) Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy. Acta Biomaterialia, [PMID:38141933] |
2. Xie Xu, Nana Tao, Caihua Sun, Robert D. Hoffman, Dongling Shi, Yuyuan Ying, Shujie Dong, Jianli Gao. (2023) Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells. PHYTOMEDICINE, (155216). [PMID:38061285] |
3. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (19): [PMID:37870273] |
4. Kangjia Ding, Xueke Yu, Dongfang Wang, Xiaofeng Wang, Qian Li. (2023) Small diameter expanded polytetrafluoroethylene vascular graft with differentiated inner and outer biomacromolecules for collaborative endothelialization, anti-thrombogenicity and anti-inflammation. COLLOIDS AND SURFACES B-BIOINTERFACES, 229 (113449). [PMID:37506438] |
5. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2023) Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10914). [PMID:37446088] |
6. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu. (2023) A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood. Journal of Materials Chemistry B, 11 (20): (4464-4474). [PMID:37159048] |
7. Caihua Wang, Xiaofang Li, Wei Zhang, Wenxuan Liu, Ziwei Lv, Runlin Gui, Man Li, Yujia Li, Xiaomin Sun, Ping Liu, Xiaobin Fan, Shiyao Yang, Yuyan Xiong, Lu Qian. (2023) ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance. FREE RADICAL BIOLOGY AND MEDICINE, 199 (126). [PMID:36841363] |
8. Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song. (2023) Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation. PHYTOTHERAPY RESEARCH, 37 (4): (1377-1390). [PMID:36751963] |
9. Han Chengzhi, Qian Xinyi, Ren Xiaorong, Zhang Shutian, Hu Li, Li Jingyao, Huang Yijun, Huang Renhui, Ooi Kokwin, Lin Hong, Xia Chunmei. (2022) Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy. MOLECULAR NEUROBIOLOGY, 59 (11): (7006-7024). [PMID:36070120] |
10. Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang. (2022) White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp. PLoS Pathogens, 18 (9): (e1010808). [PMID:36067252] |
11. Rui Wang, Jian Lu, Jiasheng Yin, Han Chen, Hongmei Liu, Fei Xu, Tongtong Zang, Rende Xu, Chenguang Li, Yizhe Wu, Qilin Wu, Xiang Fei, Meifang Zhu, Li Shen, Junbo Ge. (2023) A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation. Bioactive Materials, 19 (666). [PMID:35600979] |
12. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen. (2022) N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (259). [PMID:35513096] |
13. Yanzhen Han, Yan Zhou, Liyuan Zhou, Xiaoyan Jia, Xiangjun Yu, Xiaohong An, Zhe Shi. (2022) Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 100 (7): [PMID:35413227] |
14. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] |