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Rapamycin - ≥95%(HPLC), high purity , CAS No.53123-88-9

27 Citations
Item Number
S293790
Grouped product items
SKUSizeAvailabilityPrice Qty
S293790-50mg
50mg
In stock
$19.90
S293790-250mg
250mg
In stock
$79.90
S293790-1g
1g
In stock
$169.90
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Basic Description

SynonymsAY 22989 | AY-22989 | CHEBI:9168 | EC 610-965-5 | HMS2089A21 | RAPA | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl
Specifications & PurityMoligand™, ≥95%(HPLC)
Biochemical and Physiological MechanismsA macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has antica
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.

Associated Targets(Human)

FKBP1A Tclin Peptidyl-prolyl cis-trans isomerase FKBP1A (10 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FKBP1B Tchem Peptidyl-prolyl cis-trans isomerase FKBP1B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FKBP5 Tchem Peptidyl-prolyl cis-trans isomerase FKBP5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EIF4E Tchem Eukaryotic translation initiation factor 4E (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDCD4 Tchem Programmed cell death protein 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MTOR Tclin Serine/threonine-protein kinase mTOR (7 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
INCHI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChi Key QFJCIRLUMZQUOT-HPLJOQBZSA-N
Canonical SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
Isomeric SMILES C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
RTECS VE6250000
Molecular Weight 914.19
Reaxy-Rn 5848501

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
L2403373Certificate of AnalysisNov 22, 2024 S293790
L2403374Certificate of AnalysisNov 22, 2024 S293790
A2307041Certificate of AnalysisOct 21, 2024 S293790
A2307034Certificate of AnalysisOct 21, 2024 S293790
A2307025Certificate of AnalysisOct 21, 2024 S293790
A2307033Certificate of AnalysisOct 11, 2024 S293790
A2307038Certificate of AnalysisOct 11, 2024 S293790
E2225234Certificate of AnalysisFeb 23, 2024 S293790
E2225235Certificate of AnalysisFeb 23, 2024 S293790
E2225238Certificate of AnalysisFeb 23, 2024 S293790
A2307032Certificate of AnalysisNov 10, 2022 S293790
A2422188Certificate of AnalysisNov 10, 2022 S293790
C2428063Certificate of AnalysisNov 10, 2022 S293790
H2312240Certificate of AnalysisNov 10, 2022 S293790
A2221042Certificate of AnalysisApr 28, 2021 S293790

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Chemical and Physical Properties

SolubilitySoluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
SensitivityHeat sensitive.
Specific Rotation[α]-150° (C=0.2,MeOH)
Melt Point(°C)177 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H351:Suspected of causing cancer

H372:Causes damage to organs through prolonged or repeated exposure

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

RTECS VE6250000
Reaxy-Rn 5848501
Merck Index 8114

Related Documents

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Xie Xu, Nana Tao, Caihua Sun, Robert D. Hoffman, Dongling Shi, Yuyuan Ying, Shujie Dong, Jianli Gao.  (2023)  Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells.  PHYTOMEDICINE,    (155216).  [PMID:38061285] [10.1016/j.phymed.2023.155216]
2. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]
3. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui.  (2023)  Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,    (19):   [PMID:37870273] [10.1021/acs.jafc.3c01244]
4. Kangjia Ding, Xueke Yu, Dongfang Wang, Xiaofeng Wang, Qian Li.  (2023)  Small diameter expanded polytetrafluoroethylene vascular graft with differentiated inner and outer biomacromolecules for collaborative endothelialization, anti-thrombogenicity and anti-inflammation.  COLLOIDS AND SURFACES B-BIOINTERFACES,  229  (113449).  [PMID:37506438] [10.1016/j.colsurfb.2023.113449]
5. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu.  (2023)  Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (13): (10914).  [PMID:37446088] [10.3390/ijms241310914]
6. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu.  (2023)  A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood.  Journal of Materials Chemistry B,  11  (20): (4464-4474).  [PMID:37159048] [10.1039/D3TB00569K]
7. Caihua Wang, Xiaofang Li, Wei Zhang, Wenxuan Liu, Ziwei Lv, Runlin Gui, Man Li, Yujia Li, Xiaomin Sun, Ping Liu, Xiaobin Fan, Shiyao Yang, Yuyan Xiong, Lu Qian.  (2023)  ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance.  FREE RADICAL BIOLOGY AND MEDICINE,  199  (126).  [PMID:36841363] [10.1016/j.freeradbiomed.2023.02.017]
8. Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song.  (2023)  Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation.  PHYTOTHERAPY RESEARCH,  37  (4): (1377-1390).  [PMID:36751963] [10.1002/ptr.7746]
9. Han Chengzhi, Qian Xinyi, Ren Xiaorong, Zhang Shutian, Hu Li, Li Jingyao, Huang Yijun, Huang Renhui, Ooi Kokwin, Lin Hong, Xia Chunmei.  (2022)  Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.  MOLECULAR NEUROBIOLOGY,  59  (11): (7006-7024).  [PMID:36070120] [10.1007/s12035-022-02994-1]
10. Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang.  (2022)  White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp.  PLoS Pathogens,  18  (9): (e1010808).  [PMID:36067252] [10.1371/journal.ppat.1010808]
11. Rui Wang, Jian Lu, Jiasheng Yin, Han Chen, Hongmei Liu, Fei Xu, Tongtong Zang, Rende Xu, Chenguang Li, Yizhe Wu, Qilin Wu, Xiang Fei, Meifang Zhu, Li Shen, Junbo Ge.  (2023)  A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation.  Bioactive Materials,  19  (666).  [PMID:35600979] [10.1016/j.bioactmat.2022.04.033]
12. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen.  (2022)  N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  211  (259).  [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180]
13. Yanzhen Han, Yan Zhou, Liyuan Zhou, Xiaoyan Jia, Xiangjun Yu, Xiaohong An, Zhe Shi.  (2022)  Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy.  CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,  100  (7):   [PMID:35413227] [10.1139/cjpp-2022-0058]
14. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang.  (2021)  Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  22  (21): (11466).  [PMID:34768896] [10.3390/ijms222111466]
15. Sun Shouxiang, Cao Xiaojuan, Castro L. Filipe C., Monroig Óscar, Gao Jian.  (2021)  A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity.  FUNCTIONAL & INTEGRATIVE GENOMICS,  21  (5): (557-570).  [PMID:34327622] [10.1007/s10142-021-00798-5]
16. Li Luo, Guangchao Zang, Boyan Liu, Xian Qin, Yuchan Zhang, Yidan Chen, Haijun Zhang, Wei Wu, Guixue Wang.  (2021)  Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury.  Theranostics,  11  (16): ( 8043–8056).  [PMID:34335979] [10.7150/thno.60785]
17. Zhang Yin, Wang Qinge, Xu Yuping, Sun Jing, Ding Yanbo, Wang Li, Chen Bingfang, Sun Kewen, Chen Jianping.  (2021)  Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b.  Frontiers in Molecular Biosciences,  8    [PMID:34079820] [10.3389/fmolb.2021.675757]
18. Chao Gu, Junqing Yang, Ying Luo, Dongzhi Ran, Xiaodan Tan, Pu Xiang, Huizhi Fei, Yi Lu, Wenjia Guo, Yujun Tu, Xia Liu, Hong Wang.  (2021)  ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy.  EXPERIMENTAL NEUROLOGY,  342  (113759).  [PMID:33992580] [10.1016/j.expneurol.2021.113759]
19. Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Lin Hong, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou.  (2021)  Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors.  Theranostics,  11  (9): ( 4335–4350).  [PMID:33754064] [10.7150/thno.52077]
20. He Bingnan, Wang Xia, Jin Xini, Xue Zimeng, Zhu Jianbo, Wang Caiyun, Jin Yuanxiang, Fu Zhengwei.  (2020)  β-Cypermethrin promotes the adipogenesis of 3T3-L1 cells via inducing autophagy and shaping an adipogenesis-friendly microenvironment.  ACTA BIOCHIMICA ET BIOPHYSICA SINICA,  52  (8): (821-831).  [PMID:32637997] [10.1093/abbs/gmaa049]
21. Yilin Zhang, Dongwei Liu, Zhangsuo Liu.  (2020)  The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  195  (110403).  [PMID:32193019] [10.1016/j.ecoenv.2020.110403]
22. Bingnan He, Xia Wang, Jianbo Zhu, Baida Kong, Lai Wei, Yuanxiang Jin, Zhengwei Fu.  (2019)  Autophagy protects murine macrophages from β-cypermethrin-induced mitochondrial dysfunction and cytotoxicity via the reduction of oxidation stress.  ENVIRONMENTAL POLLUTION,  250  (416).  [PMID:31026688] [10.1016/j.envpol.2019.04.044]
23. Li Qiang, Yin Yating, Zheng Yuqing, Chen Feifei, Jin Peisheng.  (2018)  Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs.  Stem Cell Research & Therapy,  9  (1): (1-11).  [PMID:30359319] [10.1186/s13287-018-1029-4]
24. Yang Su, Jingxiao Lu, Pian Gong, Xianguo Chen, Chaozhao Liang, Jie Zhang.  (2018)  Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway.  Molecular Medicine Reports,  18  (6): (5445-5454).  [PMID:30365078] [10.3892/mmr.2018.9586]
25. Ting Wang, Jinhui Hu, Hao Luo, Huiyang Li, Jiahong Zhou, Lin Zhou, Shaohua Wei.  (2018)  Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression.  Small,  14  (38): (1802337).  [PMID:30152186] [10.1002/smll.201802337]
26. Wang Meng, Huang Can, Su Yong, Yang Cui, Xia Quan, Xu Du-juan.  (2017)  Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  69  (6): (743-752).  [PMID:28266023] [10.1111/jphp.12706]
27. Wei-Rong Yang, Yong Wang, Yi Wang, Jiao-Jiao Zhang, Jia-Hua Zhang, Cheng Lu, Xian-Zhong Wang.  (2015)  mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1.  MOLECULAR REPRODUCTION AND DEVELOPMENT,  82  (4): (305-314).  [PMID:25739982] [10.1002/mrd.22473]

References

1. Xie Xu, Nana Tao, Caihua Sun, Robert D. Hoffman, Dongling Shi, Yuyuan Ying, Shujie Dong, Jianli Gao.  (2023)  Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells.  PHYTOMEDICINE,    (155216).  [PMID:38061285] [10.1016/j.phymed.2023.155216]
2. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]
3. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui.  (2023)  Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,    (19):   [PMID:37870273] [10.1021/acs.jafc.3c01244]
4. Kangjia Ding, Xueke Yu, Dongfang Wang, Xiaofeng Wang, Qian Li.  (2023)  Small diameter expanded polytetrafluoroethylene vascular graft with differentiated inner and outer biomacromolecules for collaborative endothelialization, anti-thrombogenicity and anti-inflammation.  COLLOIDS AND SURFACES B-BIOINTERFACES,  229  (113449).  [PMID:37506438] [10.1016/j.colsurfb.2023.113449]
5. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu.  (2023)  Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (13): (10914).  [PMID:37446088] [10.3390/ijms241310914]
6. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu.  (2023)  A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood.  Journal of Materials Chemistry B,  11  (20): (4464-4474).  [PMID:37159048] [10.1039/D3TB00569K]
7. Caihua Wang, Xiaofang Li, Wei Zhang, Wenxuan Liu, Ziwei Lv, Runlin Gui, Man Li, Yujia Li, Xiaomin Sun, Ping Liu, Xiaobin Fan, Shiyao Yang, Yuyan Xiong, Lu Qian.  (2023)  ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance.  FREE RADICAL BIOLOGY AND MEDICINE,  199  (126).  [PMID:36841363] [10.1016/j.freeradbiomed.2023.02.017]
8. Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song.  (2023)  Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation.  PHYTOTHERAPY RESEARCH,  37  (4): (1377-1390).  [PMID:36751963] [10.1002/ptr.7746]
9. Han Chengzhi, Qian Xinyi, Ren Xiaorong, Zhang Shutian, Hu Li, Li Jingyao, Huang Yijun, Huang Renhui, Ooi Kokwin, Lin Hong, Xia Chunmei.  (2022)  Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.  MOLECULAR NEUROBIOLOGY,  59  (11): (7006-7024).  [PMID:36070120] [10.1007/s12035-022-02994-1]
10. Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang.  (2022)  White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp.  PLoS Pathogens,  18  (9): (e1010808).  [PMID:36067252] [10.1371/journal.ppat.1010808]
11. Rui Wang, Jian Lu, Jiasheng Yin, Han Chen, Hongmei Liu, Fei Xu, Tongtong Zang, Rende Xu, Chenguang Li, Yizhe Wu, Qilin Wu, Xiang Fei, Meifang Zhu, Li Shen, Junbo Ge.  (2023)  A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation.  Bioactive Materials,  19  (666).  [PMID:35600979] [10.1016/j.bioactmat.2022.04.033]
12. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen.  (2022)  N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  211  (259).  [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180]
13. Yanzhen Han, Yan Zhou, Liyuan Zhou, Xiaoyan Jia, Xiangjun Yu, Xiaohong An, Zhe Shi.  (2022)  Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy.  CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,  100  (7):   [PMID:35413227] [10.1139/cjpp-2022-0058]
14. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang.  (2021)  Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  22  (21): (11466).  [PMID:34768896] [10.3390/ijms222111466]
15. Sun Shouxiang, Cao Xiaojuan, Castro L. Filipe C., Monroig Óscar, Gao Jian.  (2021)  A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity.  FUNCTIONAL & INTEGRATIVE GENOMICS,  21  (5): (557-570).  [PMID:34327622] [10.1007/s10142-021-00798-5]
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