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RasGRP activator 1 , CAS No.R613102, Activator of protein kinase C alpha;Activator of protein kinase C epsilon;Activator of RAS guanyl releasing protein 1

Item Number
R613102
Grouped product items
SKUSizeAvailabilityPrice Qty
R613102-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
R613102-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
protein kinase C alpha Activator protein kinase C epsilon Activator RAS guanyl releasing protein 1 Activator

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of protein kinase C alpha;Activator of protein kinase C epsilon;Activator of RAS guanyl releasing protein 1

Associated Targets(Human)

RASGRP3 Tchem Ras guanyl-releasing protein 3 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RASGRP1 Tchem RAS guanyl-releasing protein 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCE Tchem Protein kinase C epsilon type (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCA Tchem Protein kinase C alpha type (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCE Tchem Protein kinase C epsilon (1520 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCA Tchem Protein kinase C alpha (5923 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RASGRP3 Tchem RAS guanyl releasing protein 3 (130 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RASGRP1 Tchem RAS guanyl-releasing protein 1 (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKD3 Tchem Protein kinase C (PKC) (1010 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Prkcd Protein kinase C delta (192 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(4E)-2-(hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoate
INCHI InChI=1S/C24H31NO5/c1-4-8-17(9-5-2)22(27)29-16-24(15-26)13-18(23(28)30-24)12-19-14-25(3)21-11-7-6-10-20(19)21/h6-7,10-12,14,17,26H,4-5,8-9,13,15-16H2,1-3H3/b18-12+
InChi Key SIWILCBNYOGJQH-LDADJPATSA-N
Canonical SMILES CCCC(C(=O)OCC1(CO)OC(=O)/C(=C/c2cn(c3c2cccc3)C)/C1)CCC
Isomeric SMILES CCCC(CCC)C(=O)OCC1(C/C(=C\C2=CN(C3=CC=CC=C32)C)/C(=O)O1)CO
PubChem CID 25053598

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE et al..  (2014)  Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP..  Bioorg Med Chem,  22  (12): (3123-40).  [PMID:24794745] [10.1021/op500134e]

Solution Calculators

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