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RasGRP activator 1 , CAS No.R613102, Activator of protein kinase C alpha;Activator of protein kinase C epsilon;Activator of RAS guanyl releasing protein 1

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RasGRP activator 1 , CAS No.R613102, Activator of protein kinase C alpha;Activator of protein kinase C epsilon;Activator of RAS guanyl releasing protein 1

Moligand™

PubChem CID: 25053598

Item Number

R613102

Grouped product items
SKU	Size	Availability	Price	Qty
R613102-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613102-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

protein kinase C alpha Activator protein kinase C epsilon Activator RAS guanyl releasing protein 1 Activator

Basic Description

Synonyms	compound 1
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of protein kinase C alpha;Activator of protein kinase C epsilon;Activator of RAS guanyl releasing protein 1

Associated Targets(Human)

RASGRP3 Tchem Ras guanyl-releasing protein 3 (3 Activities)

Discover Target: RASGRP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RASGRP1 Tchem RAS guanyl-releasing protein 1 (3 Activities)

Discover Target: RASGRP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon type (2 Activities)

Discover Target: PRKCE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCA Tchem Protein kinase C alpha type (4 Activities)

Discover Target: PRKCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon (1520 Activities)

Discover Target: PRKCE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCA Tchem Protein kinase C alpha (5923 Activities)

Discover Target: PRKCA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RASGRP3 Tchem RAS guanyl releasing protein 3 (130 Activities)

Discover Target: RASGRP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RASGRP1 Tchem RAS guanyl-releasing protein 1 (22 Activities)

Discover Target: RASGRP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKD3 Tchem Protein kinase C (PKC) (1010 Activities)

Discover Target: PRKD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Prkcd Protein kinase C delta (192 Activities)

Discover Target: Prkcd

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[(4E)-2-(hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoate
INCHI	InChI=1S/C24H31NO5/c1-4-8-17(9-5-2)22(27)29-16-24(15-26)13-18(23(28)30-24)12-19-14-25(3)21-11-7-6-10-20(19)21/h6-7,10-12,14,17,26H,4-5,8-9,13,15-16H2,1-3H3/b18-12+
InChi Key	SIWILCBNYOGJQH-LDADJPATSA-N
Canonical SMILES	CCCC(C(=O)OCC1(CO)OC(=O)/C(=C/c2cn(c3c2cccc3)C)/C1)CCC
Isomeric SMILES	CCCC(CCC)C(=O)OCC1(C/C(=C\C2=CN(C3=CC=CC=C32)C)/C(=O)O1)CO
PubChem CID	25053598

Database links

PubChem CID	25053598
ChEMBL Ligand	CHEMBL519741
BindingDB Ligand	50244449

Certificates

Certificate of Analysis(COA)

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References

1. Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE et al.. (2014) Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.. Bioorg Med Chem, 22 (12): (3123-40). [PMID:24794745]

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