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Receptor tyrosine phosphatase (RTP) family
razuprotafib , Receptor-type tyrosine-protein phosphatase beta inhibitor, CAS No.1008510-37-9, Receptor-type tyrosine-protein phosphatase beta inhibitor

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razuprotafib , Receptor-type tyrosine-protein phosphatase beta inhibitor, CAS No.1008510-37-9, Receptor-type tyrosine-protein phosphatase beta inhibitor

Moligand™

CAS#: 1008510-37-9
Formula: C₂₆H₂₆N₄O₆S₃
Molecular Weight: 586.7
PubChem CID: 46700782

Item Number

R613105

Grouped product items
SKU	Size	Availability	Price	Qty
R613105-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613105-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,897.90

View related series

RTP Type B Inhibitor

Basic Description

Synonyms	Compound AA34 [US10220048] \| AKOS040742534 \| Razuprotafib [USAN] \| RAZUPROTAFIB [WHO-DD] \| N-(4-{(2S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-phenylpropanamido}-2-[2-(thiophen-2-yl)-1,3-thiazol-4-yl]ethyl}phenyl)sulfamic acid \| Razuprotafib \| CS-0031483 \| MS
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Receptor-type tyrosine-protein phosphatase beta inhibitor

Product Properties

ALogP	3.7

Associated Targets(Human)

PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (0 Activities)

Discover Target: PTPRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[4-[(2S)-2-[[(2S)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-thiophen-2-yl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid
INCHI	InChI=1S/C26H26N4O6S3/c1-36-26(32)29-21(15-17-6-3-2-4-7-17)24(31)27-20(22-16-38-25(28-22)23-8-5-13-37-23)14-18-9-11-19(12-10-18)30-39(33,34)35/h2-13,16,20-21,30H,14-15H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t20-,21-/m0/s1
InChi Key	KWJDHELCGJFUHW-SFTDATJTSA-N
Canonical SMILES	COC(=O)N[C@H](C(=O)N[C@H](c1csc(n1)c1cccs1)Cc1ccc(cc1)NS(=O)(=O)O)Cc1ccccc1
Isomeric SMILES	COC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4
PubChem CID	46700782
Molecular Weight	586.7

Database links

ChEMBL Ligand	CHEMBL3931971
PubChem CID	46700782
BindingDB Ligand	359124
CAS Registry No.	1008510-37-9

Certificates

Certificate of Analysis(COA)

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References

1. Shen J, Frye M, Lee BL, Reinardy JL, McClung JM, Ding K, Kojima M, Xia H, Seidel C, Lima e Silva R et al.. (2014) Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.. J Clin Invest, 124 (10): (4564-76). [PMID:25180601] [10.1021/op500134e]

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