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RE 201 - 98%, high purity , Type-1 angiotensin II receptor antagonist, CAS No.254740-64-2, Type-1 angiotensin II receptor antagonist

Moligand™

≥98%

CAS#: 254740-64-2
Formula: C₃₂H₄₀N₄O₅S
Molecular Weight: 592.75
PubChem CID: 10257882

Item Number

R340645

Grouped product items
SKU	Size	Availability	Price
R340645-25mg	25mg	In stock	$489.90
R340645-50mg	50mg	In stock	$815.90
R340645-100mg	100mg	In stock	$1,360.90
R340645-250mg	250mg	In stock	$3,062.90

View related series

AT1 receptor Antagonist ETA receptor Antagonist

Basic Description

Synonyms	retrophin \| BDBM50175523 \| GN \| Sparsentan [USAN] \| sparsentanum \| compound 7 (PMID 15634011) \| esparsentan \| IDI1_007881 \| Sparsentan (USAN/INN) \| AC-35179 \| BCP23969 \| EX-A3048 \| Sparsentan(PS433540) \| F77045 \| Q27088845 \| 9242RO5URM \| AKOS040758741 \| s
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Type-1 angiotensin II receptor antagonist

Associated Targets(Human)

AGTR1 Tclin Type-1 angiotensin II receptor (3 Activities)

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor (3 Activities)

Discover Target: EDNRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EDNRA Tclin Endothelin receptor ET-A (5008 Activities)

Discover Target: EDNRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr1b Angiotensin II receptor (AT-1) type-1 (1480 Activities)

Discover Target: Agtr1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide
INCHI	InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
InChi Key	WRFHGDPIDHPWIQ-UHFFFAOYSA-N
Canonical SMILES	CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
Isomeric SMILES	CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
PubChem CID	10257882
Molecular Weight	592.75

PubChem CID

ChEMBL Ligand

CAS Registry No.

BindingDB Ligand

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
K2223528	Certificate of Analysis	Jul 22, 2022	R340645
K2223531	Certificate of Analysis	Jul 22, 2022	R340645
K2223532	Certificate of Analysis	Jul 22, 2022	R340645
K2223533	Certificate of Analysis	Jul 22, 2022	R340645

References

1. Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Valentine MT et al.. (2005) Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.. J Med Chem, 48 (1): (171-9). [PMID:15634011]
2. Morphy R, Rankovic Z. (2005) Designed multiple ligands. An emerging drug discovery paradigm.. J Med Chem, 48 (21): (6523-43). [PMID:16220969]
3. D'Agati VD, Kaskel FJ, Falk RJ. (2011) Focal segmental glomerulosclerosis.. N Engl J Med, 365 (25): (2398-411). [PMID:22187987]
4. Hodson EM, Sinha A, Cooper TE. (2022) Interventions for focal segmental glomerulosclerosis in adults.. Cochrane Database Syst Rev, 2 (2): (CD003233). [PMID:35224732]

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