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RE 201 - 98%, high purity , Type-1 angiotensin II receptor antagonist, CAS No.254740-64-2, Type-1 angiotensin II receptor antagonist
Basic Description Synonyms retrophin | BDBM50175523 | GN | Sparsentan [USAN] | sparsentanum | compound 7 (PMID 15634011) | esparsentan | IDI1_007881 | Sparsentan (USAN/INN) | AC-35179 | BCP23969 | EX-A3048 | Sparsentan(PS433540) | F77045 | Q27088845 | 9242RO5URM | AKOS040758741 | s Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Type-1 angiotensin II receptor antagonist
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide INCHI InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35) InChi Key WRFHGDPIDHPWIQ-UHFFFAOYSA-N Canonical SMILES CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC Isomeric SMILES CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC PubChem CID 10257882 Molecular Weight 592.75
References 1. Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Valentine MT et al. . (2005) Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.. J Med Chem, 48 (1): (171-9). [PMID:15634011 ] [10.1021/op500134e ] 2. Morphy R, Rankovic Z. (2005) Designed multiple ligands. An emerging drug discovery paradigm.. J Med Chem, 48 (21): (6523-43). [PMID:16220969 ] [10.1021/op500134e ] 3. D'Agati VD, Kaskel FJ, Falk RJ. (2011) Focal segmental glomerulosclerosis.. N Engl J Med, 365 (25): (2398-411). [PMID:22187987 ] [10.1021/op500134e ] 4. Hodson EM, Sinha A, Cooper TE. (2022) Interventions for focal segmental glomerulosclerosis in adults.. Cochrane Database Syst Rev, 2 (2): (CD003233). [PMID:35224732 ] [10.1021/op500134e ]
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