Rebamipide enhances mucosal resistance, increases prostaglandin in gastric mucosa, and also scavenges oxygen-derived free radicals and inhibits their production.Derivative of 2-(1 H )-quinolinone with multiple biological activities. Stimulates prostagland
Shipped In
Normal
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of CCK 1 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM. An inducer of endogenous prostaglandin and a oxygen-derived free radical scavenger.
product description：
Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner；
1.Ishihara K, Komuro Y, Nishiyama N, Yamasaki K, Hotta K. (1992) Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa.. Arzneimittelforschung, 42 (12):(1462-6). [PMID:1337697]
2.Tarnawski AS, Chai J, Pai R, Chiou SK. (2004) Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?. Dig Dis Sci, 49 (2):(202-9). [PMID:15104358]
3.Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K. (1995) Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine.. Dig Dis Sci, 40 (11):(2469-72). [PMID:7587834]
4.Yoshikawa T, Naito Y, Tanigawa T, Kondo M. (1993) Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance.. Arzneimittelforschung, 43 (3):(363-6). [PMID:8387788]
5.Kleine A, Kluge S, Peskar BM. (1993) Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats.. Dig Dis Sci, 38 (8):(1441-9). [PMID:8393757]
6.Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A. (1998) Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.. Dig Dis Sci, 43 (9 Suppl):(5S-13S). [PMID:9753220]
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