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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R129303-1g | 1g | In stock | $64.90 | |
R129303-5g | 5g | In stock | $182.90 | |
R129303-10g | 10g | In stock | $329.90 | |
R129303-25g | 25g | In stock | $741.90 | |
R129303-100g | 100g | In stock | $2,668.90 |
Derivative of 2-(1H)-quinolinone with multiple biological activities
Synonyms | 2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid | s2032 | (+-)-2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid | CAS-90098-04-7 | N-[(4-chlorophenyl)carbonyl]-3-(2-oxo-1,2-dihydroquinolin-4-yl)alanine | NCGC00095161-03 | SR- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Rebamipide enhances mucosal resistance, increases prostaglandin in gastric mucosa, and also scavenges oxygen-derived free radicals and inhibits their production.Derivative of 2-(1 H )-quinolinone with multiple biological activities. Stimulates prostagland |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of CCK 1 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM. product description: Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner; |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179871 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179871 |
IUPAC Name | 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid |
INCHI | InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26) |
InChi Key | ALLWOAVDORUJLA-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl |
Isomeric SMILES | C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl |
RTECS | VC2518500 |
PubChem CID | 5042 |
Molecular Weight | 370.79 |
Reaxy-Rn | 5384689 |
PubChem CID | 5042 |
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Wikipedia | Rebamipide |
CAS Registry No. | 90098-04-7 |
ChEMBL Ligand | CHEMBL1697771 |
DrugCentral Ligand | 2360 |
GPCRdb Ligand | rebamipide |
PubChem SID | 488179871 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2212312 | Certificate of Analysis | Jun 20, 2024 | R129303 |
I2212313 | Certificate of Analysis | Jun 20, 2024 | R129303 |
I2212314 | Certificate of Analysis | Jun 20, 2024 | R129303 |
L2121598 | Certificate of Analysis | Oct 08, 2023 | R129303 |
L2121648 | Certificate of Analysis | Oct 08, 2023 | R129303 |
L2121651 | Certificate of Analysis | Oct 08, 2023 | R129303 |
H2329556 | Certificate of Analysis | Aug 14, 2023 | R129303 |
H2329758 | Certificate of Analysis | Aug 14, 2023 | R129303 |
H2329805 | Certificate of Analysis | Aug 14, 2023 | R129303 |
H2329806 | Certificate of Analysis | Aug 14, 2023 | R129303 |
F1502091 | Certificate of Analysis | Jan 25, 2023 | R129303 |
D23261178 | Certificate of Analysis | Jul 24, 2022 | R129303 |
I2212315 | Certificate of Analysis | Jul 24, 2022 | R129303 |
Solubility | Soluble in DMSO (74 mg/mL at 25 °C), methanol (Heat), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C). |
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Melt Point(°C) | 290°C(dec.)(lit.) |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
RTECS | VC2518500 |
Reaxy-Rn | 5384689 |
Merck Index | 8124 |
Starting at $156.90
Starting at $49.90
1. Han Qiao, Zhuo Xu, Mengchi Sun, Shuwen Fu, Fangxue Zhao, Danping Wang, Zhonggui He, Yinglei Zhai, Jin Sun. (2022) Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 75 (103654). [PMID:] [10.1016/j.jddst.2022.103654] |
1. Ishihara K, Komuro Y, Nishiyama N, Yamasaki K, Hotta K. (1992) Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa.. Arzneimittelforschung, 42 (12): (1462-6). [PMID:1337697] [10.1021/op500134e] |
2. Tarnawski AS, Chai J, Pai R, Chiou SK. (2004) Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?. Dig Dis Sci, 49 (2): (202-9). [PMID:15104358] [10.1021/op500134e] |
3. Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K. (1995) Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine.. Dig Dis Sci, 40 (11): (2469-72). [PMID:7587834] [10.1021/op500134e] |
4. Yoshikawa T, Naito Y, Tanigawa T, Kondo M. (1993) Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance.. Arzneimittelforschung, 43 (3): (363-6). [PMID:8387788] [10.1021/op500134e] |
5. Kleine A, Kluge S, Peskar BM. (1993) Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats.. Dig Dis Sci, 38 (8): (1441-9). [PMID:8393757] [10.1021/op500134e] |
6. Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A. (1998) Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.. Dig Dis Sci, 43 (9 Suppl): (5S-13S). [PMID:9753220] [10.1021/op500134e] |
7. Han Qiao, Zhuo Xu, Mengchi Sun, Shuwen Fu, Fangxue Zhao, Danping Wang, Zhonggui He, Yinglei Zhai, Jin Sun. (2022) Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 75 (103654). [PMID:] [10.1016/j.jddst.2022.103654] |