Rebamipide - ≥98%, high purity , CAS No.90098-04-7, Agonist of CCK 1 receptor

Item Number
R129303
Grouped product items
SKUSizeAvailabilityPrice Qty
R129303-1g
1g
In stock
$64.90
R129303-5g
5g
In stock
$182.90
R129303-10g
10g
In stock
$329.90
R129303-25g
25g
In stock
$741.90
R129303-100g
100g
In stock
$2,668.90

Derivative of 2-(1H)-quinolinone with multiple biological activities

View related series
CCK1 receptor Agonist

Basic Description

Synonyms2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid | s2032 | (+-)-2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid | CAS-90098-04-7 | N-[(4-chlorophenyl)carbonyl]-3-(2-oxo-1,2-dihydroquinolin-4-yl)alanine | NCGC00095161-03 | SR-
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsRebamipide enhances mucosal resistance, increases prostaglandin in gastric mucosa, and also scavenges oxygen-derived free radicals and inhibits their production.Derivative of 2-(1 H )-quinolinone with multiple biological activities. Stimulates prostagland
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of CCK 1 receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.
An inducer of endogenous prostaglandin and a oxygen-derived free radical scavenger.


product description:

Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner;

Associated Targets(Human)

CCKAR Tclin Cholecystokinin receptor type A (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179871
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179871
IUPAC Name 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
INCHI InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)
InChi Key ALLWOAVDORUJLA-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
Isomeric SMILES C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
RTECS VC2518500
PubChem CID 5042
Molecular Weight 370.79
Reaxy-Rn 5384689

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
I2212312Certificate of AnalysisJun 20, 2024 R129303
I2212313Certificate of AnalysisJun 20, 2024 R129303
I2212314Certificate of AnalysisJun 20, 2024 R129303
L2121598Certificate of AnalysisOct 08, 2023 R129303
L2121648Certificate of AnalysisOct 08, 2023 R129303
L2121651Certificate of AnalysisOct 08, 2023 R129303
H2329556Certificate of AnalysisAug 14, 2023 R129303
H2329758Certificate of AnalysisAug 14, 2023 R129303
H2329805Certificate of AnalysisAug 14, 2023 R129303
H2329806Certificate of AnalysisAug 14, 2023 R129303
F1502091Certificate of AnalysisJan 25, 2023 R129303
D23261178Certificate of AnalysisJul 24, 2022 R129303
I2212315Certificate of AnalysisJul 24, 2022 R129303

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Chemical and Physical Properties

SolubilitySoluble in DMSO (74 mg/mL at 25 °C), methanol (Heat), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C).
Melt Point(°C)290°C(dec.)(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

RTECS VC2518500
Reaxy-Rn 5384689
Merck Index 8124

Related Documents

Citations of This Product

1. Han Qiao, Zhuo Xu, Mengchi Sun, Shuwen Fu, Fangxue Zhao, Danping Wang, Zhonggui He, Yinglei Zhai, Jin Sun.  (2022)  Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  75  (103654).  [PMID:] [10.1016/j.jddst.2022.103654]

References

1. Ishihara K, Komuro Y, Nishiyama N, Yamasaki K, Hotta K.  (1992)  Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa..  Arzneimittelforschung,  42  (12): (1462-6).  [PMID:1337697] [10.1021/op500134e]
2. Tarnawski AS, Chai J, Pai R, Chiou SK.  (2004)  Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?.  Dig Dis Sci,  49  (2): (202-9).  [PMID:15104358] [10.1021/op500134e]
3. Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K.  (1995)  Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine..  Dig Dis Sci,  40  (11): (2469-72).  [PMID:7587834] [10.1021/op500134e]
4. Yoshikawa T, Naito Y, Tanigawa T, Kondo M.  (1993)  Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance..  Arzneimittelforschung,  43  (3): (363-6).  [PMID:8387788] [10.1021/op500134e]
5. Kleine A, Kluge S, Peskar BM.  (1993)  Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats..  Dig Dis Sci,  38  (8): (1441-9).  [PMID:8393757] [10.1021/op500134e]
6. Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A.  (1998)  Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing..  Dig Dis Sci,  43  (9 Suppl): (5S-13S).  [PMID:9753220] [10.1021/op500134e]
7. Han Qiao, Zhuo Xu, Mengchi Sun, Shuwen Fu, Fangxue Zhao, Danping Wang, Zhonggui He, Yinglei Zhai, Jin Sun.  (2022)  Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  75  (103654).  [PMID:] [10.1016/j.jddst.2022.103654]

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