Grouped product items

SKU

Size

Availability

Price

Qty

Ab088973-10μl

10μl

Available within 8-12 weeks(?)

$66.90

Ab088973-50μl

50μl

Available within 4-8 weeks(?)

$198.90

Ab088973-100μl

100μl

Available within 4-8 weeks(?)

$300.90

Ab088973-1ml

1ml

Available within 8-12 weeks(?)

$2,250.90

Basic Description

Product Name	Recombinant ANXA2 Antibody - Primary antibody, for WB,IF,ICC various applications, from Human, generated in Rabbit, specific to ANXA2, Rabbit IgG
Synonyms	Annexin A2 antibody \| Annexin II antibody \| Annexin II,heavy chain antibody \| Annexin-2 antibody \| ANX 2 antibody \| ANX2 antibody \| ANX2L4 antibody \| ANXA2 antibody \| ANXA2_HUMAN antibody \| arylsulfatase B antibody \| CAL1H antibody \| Calpactin I heavy cha
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.3 mg/mL
Host Species	Rabbit
Host species	Rabbit
Specificity	ANXA2
Application	WB,IF,ICC
Immunogen	A synthetic peptide derived from human Annexin A2 (AA 33-46).
Positive Control	WB: NIH/3T3, HeLa, A549, C6 lysates. IF: HeLa cells.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human ANXA2 Antibody, Recombinant, could be used to WB, ICC, IF and so on. Application WB: 1/500-1/1000; ICC/IF: 1/50-1/200; Purity Antigen affinity purification Protein Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Post-translational Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Antigen affinity purification
Source	Cell supernatant
Form	Liquid
Concentration	0.3 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

ANXA2 Tbio Annexin A2 (0 Activities)

Discover Target: ANXA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ANXA2 Tbio Annexin A2 (15 Activities)

Discover Target: ANXA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Application

Application	Dilution info
WB	1/500-1/1000 "> 1/500-1/1000
IF/ICC	1/50-1/200 "> 1/50-1/200

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0700721	Certificate of Analysis	Jul 31, 2023	Ab088973
ZJ23F0700720	Certificate of Analysis	Jul 31, 2023	Ab088973

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References

1. Manik Goel,Adam E Sienkiewicz,Renata Picciani,Richard K Lee,Sanjoy K Bhattacharya. (2011-09-03) Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility.. PloS one, 6 ((8)): (e23070-e23070). [PMID:21886777]
2. Francis Impens,Lilliana Radoshevich,Pascale Cossart,David Ribet. (2014-08-13) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.. Proceedings of the National Academy of Sciences of the United States of America, 111 ((34)): (12432-12437). [PMID:25114211]
3. Reddy TR, Li C, Guo X, Myrvang HK, Fischer PM, Dekker LV.. (2011) Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.. J Med Chem, 54 (7): (2080-2094). [PMID:21375334] [10.1021/jm101212e]
4. Jindal, H K HK, Chaney, W G WG, Anderson, C W CW, Davis, R G RG and Vishwanatha, J K JK.. (1991) The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha.. The Journal of biological chemistry, (15): [PMID:1825830]
5. Spano, F F, Raugei, G G, Palla, E E, Colella, C C and Melli, M M.. (1990) Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication.. Gene, (15): [PMID:2174397]
6. Gould, K L KL, Woodgett, J R JR, Isacke, C M CM and Hunter, T T.. (1986) The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.. Molecular and cellular biology, [PMID:2946940]
7. Huang, K S KS and 9 more authors.. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.. Cell, (18): [PMID:3013422]
8. Hyatt, S L SL, Liao, L L, Chapline, C C and Jaken, S S.. (1994) Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells.. Biochemistry, (8): [PMID:8110754]
9. Wright, J F JF, Kurosky, A A and Wasi, S S.. (1994) An endothelial cell-surface form of annexin II binds human cytomegalovirus.. Biochemical and biophysical research communications, (15): [PMID:8117306]
10. Emans, N N and 6 more authors.. (1993) Annexin II is a major component of fusogenic endosomal vesicles.. The Journal of cell biology, [PMID:8449982]
11. Burger, A A and 10 more authors.. (1996) The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein.. Journal of molecular biology, (12): [PMID:8636985]
12. MacLeod, Travis J TJ, Kwon, Mijung M, Filipenko, Nolan R NR and Waisman, David M DM.. (2003) Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin.. The Journal of biological chemistry, (11): [PMID:12730231]
13. Kirshner, Julia J, Schumann, Detlef D and Shively, John E JE.. (2003) CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis.. The Journal of biological chemistry, (12): [PMID:14522961]
14. Andersen, Jens S JS and 5 more authors.. (2003) Proteomic characterization of the human centrosome by protein correlation profiling.. Nature, (4): [PMID:14654843]
15. Deora, Arunkumar B AB, Kreitzer, Geri G, Jacovina, Andrew T AT and Hajjar, Katherine A KA.. (2004) An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface.. The Journal of biological chemistry, (15): [PMID:15302870]
16. Giannakopoulos, Nadia V NV and 9 more authors.. (2005) Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.. Biochemical and biophysical research communications, (21): [PMID:16139798]
17. Zody, Michael C MC and 68 more authors.. (2006) Analysis of the DNA sequence and duplication history of human chromosome 15.. Nature, (30): [PMID:16572171]
18. Chi, An A and 16 more authors.. (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.. Journal of proteome research, [PMID:17081065]
19. Bechtel, Stephanie S and 18 more authors.. (2007) The full-ORF clone resource of the German cDNA Consortium.. BMC genomics, (31): [PMID:17974005]
20. Mayer, Gaétan G, Poirier, Steve S and Seidah, Nabil G NG.. (2008) Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.. The Journal of biological chemistry, (14): [PMID:18799458]
21. Seidah, Nabil G NG and 10 more authors.. (2012) Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.. PloS one, [PMID:22848640]
22. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): [PMID:23186163]
23. Bian, Yangyang Y and 9 more authors.. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.. Journal of proteomics, (16): [PMID:24275569]
24. Ly, Kévin K and 9 more authors.. (2014) Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.. The Journal of biological chemistry, (20): [PMID:24808179]
25. Somarajan, Sudha R SR and 5 more authors.. (2014) Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells.. mBio, (19): [PMID:25139904]
26. Bai, Dou-Sheng DS and 11 more authors.. (2016) UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.. Oncotarget, (31): [PMID:27121050]
27. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]

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Recombinant ANXA2 Antibody - Primary antibody, for WB,IF,ICC various applications, from Human, generated in Rabbit, specific to ANXA2, Rabbit IgG