Recombinant ANXA2 Antibody - Primary antibody, for WB,IF,ICC various applications, from Human, generated in Rabbit, specific to ANXA2, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human ANXA2 Antibody; WB, ICC, IF; Unconjugated

  • Application: WB,IF,ICC
  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • IF/ICC
  • WB
Item Number
Ab088973
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab088973-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab088973-50μl
50μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$198.90
Ab088973-100μl
100μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$300.90
Ab088973-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,250.90

Recombinant; Rabbit anti Human ANXA2 Antibody; WB, ICC, IF; Unconjugated

Basic Description

Product NameRecombinant ANXA2 Antibody - Primary antibody, for WB,IF,ICC various applications, from Human, generated in Rabbit, specific to ANXA2, Rabbit IgG
SynonymsAnnexin A2 antibody; Annexin II antibody; Annexin II,heavy chain antibody; Annexin-2 antibody; ANX 2 antibody; ANX2 antibody; ANX2L4 antibody; ANXA2 antibody; ANXA2_HUMAN antibody; arylsulfatase B antibody; CAL1H antibody; Calpactin I heavy chain antibody
Specifications & PurityExactAb™, Validated, Recombinant, 0.3 mg/mL
Host SpeciesRabbit
Host speciesRabbit
SpecificityANXA2
ApplicationWB,IF,ICC
ImmunogenA synthetic peptide derived from human Annexin A2 (AA 33-46).
Positive ControlWB: NIH/3T3, HeLa, A549, C6 lysates. IF: HeLa cells.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human ANXA2 Antibody, Recombinant, could be used to WB, ICC, IF and so on.

Application  

WB: 1/500-1/1000;

ICC/IF: 1/50-1/200;

Purity

Antigen affinity purification

Protein Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Post-translational

Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodAntigen affinity purification
SourceCell supernatant
FormLiquid
Concentration0.3 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

ANXA2 Tbio Annexin A2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ANXA2 Tbio Annexin A2 (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ANXA2 Tbio Annexin A2/S100-A10 (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
WB

1/500-1/1000

ICC/IF

1/50-1/200

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0700721Certificate of AnalysisJul 31, 2023 Ab088973
ZJ23F0700720Certificate of AnalysisJul 31, 2023 Ab088973

Related Documents

References

1. Manik Goel,Adam E Sienkiewicz,Renata Picciani,Richard K Lee,Sanjoy K Bhattacharya.  (2011-09-03)  Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility..  PloS one,  ((8)): (e23070-e23070).  [PMID:21886777]
2. Francis Impens,Lilliana Radoshevich,Pascale Cossart,David Ribet.  (2014-08-13)  Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli..  Proceedings of the National Academy of Sciences of the United States of America,  111  ((34)): (12432-12437).  [PMID:25114211]
3. Reddy TR, Li C, Guo X, Myrvang HK, Fischer PM, Dekker LV..  (2011)  Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction..  J Med Chem,  54  (7): (2080-2094).  [PMID:21375334]
4. Jindal, H K HK, Chaney, W G WG, Anderson, C W CW, Davis, R G RG and Vishwanatha, J K JK..  (1991)  The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha..  The Journal of biological chemistry,    (15):   [PMID:1825830]
5. Spano, F F, Raugei, G G, Palla, E E, Colella, C C and Melli, M M..  (1990)  Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication..  Gene,    (15):   [PMID:2174397]
6. Gould, K L KL, Woodgett, J R JR, Isacke, C M CM and Hunter, T T..  (1986)  The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo..  Molecular and cellular biology,      [PMID:2946940]
7. Huang, K S KS and 9 more authors..  (1986)  Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase..  Cell,    (18):   [PMID:3013422]
8. Hyatt, S L SL, Liao, L L, Chapline, C C and Jaken, S S..  (1994)  Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells..  Biochemistry,    (8):   [PMID:8110754]
9. Wright, J F JF, Kurosky, A A and Wasi, S S..  (1994)  An endothelial cell-surface form of annexin II binds human cytomegalovirus..  Biochemical and biophysical research communications,    (15):   [PMID:8117306]
10. Emans, N N and 6 more authors..  (1993)  Annexin II is a major component of fusogenic endosomal vesicles..  The Journal of cell biology,      [PMID:8449982]
11. Burger, A A and 10 more authors..  (1996)  The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein..  Journal of molecular biology,    (12):   [PMID:8636985]
12. MacLeod, Travis J TJ, Kwon, Mijung M, Filipenko, Nolan R NR and Waisman, David M DM..  (2003)  Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin..  The Journal of biological chemistry,    (11):   [PMID:12730231]
13. Kirshner, Julia J, Schumann, Detlef D and Shively, John E JE..  (2003)  CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis..  The Journal of biological chemistry,    (12):   [PMID:14522961]
14. Andersen, Jens S JS and 5 more authors..  (2003)  Proteomic characterization of the human centrosome by protein correlation profiling..  Nature,    (4):   [PMID:14654843]
15. Deora, Arunkumar B AB, Kreitzer, Geri G, Jacovina, Andrew T AT and Hajjar, Katherine A KA..  (2004)  An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface..  The Journal of biological chemistry,    (15):   [PMID:15302870]
16. Giannakopoulos, Nadia V NV and 9 more authors..  (2005)  Proteomic identification of proteins conjugated to ISG15 in mouse and human cells..  Biochemical and biophysical research communications,    (21):   [PMID:16139798]
17. Zody, Michael C MC and 68 more authors..  (2006)  Analysis of the DNA sequence and duplication history of human chromosome 15..  Nature,    (30):   [PMID:16572171]
18. Chi, An A and 16 more authors..  (2006)  Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes..  Journal of proteome research,      [PMID:17081065]
19. Bechtel, Stephanie S and 18 more authors..  (2007)  The full-ORF clone resource of the German cDNA Consortium..  BMC genomics,    (31):   [PMID:17974005]
20. Mayer, Gaétan G, Poirier, Steve S and Seidah, Nabil G NG..  (2008)  Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels..  The Journal of biological chemistry,    (14):   [PMID:18799458]
21. Seidah, Nabil G NG and 10 more authors..  (2012)  Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation..  PloS one,      [PMID:22848640]
22. Zhou, Houjiang H and 6 more authors..  (2013)  Toward a comprehensive characterization of a human cancer cell phosphoproteome..  Journal of proteome research,    (4):   [PMID:23186163]
23. Bian, Yangyang Y and 9 more authors..  (2014)  An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome..  Journal of proteomics,    (16):   [PMID:24275569]
24. Ly, Kévin K and 9 more authors..  (2014)  Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9..  The Journal of biological chemistry,    (20):   [PMID:24808179]
25. Somarajan, Sudha R SR and 5 more authors..  (2014)  Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells..  mBio,    (19):   [PMID:25139904]
26. Bai, Dou-Sheng DS and 11 more authors..  (2016)  UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2..  Oncotarget,    (31):   [PMID:27121050]
27. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge.  (2011-01-29)  Initial characterization of the human central proteome..  BMC systems biology,  (17-17).  [PMID:21269460]

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