Recombinant ApoER2 Antibody - Primary antibody, specific to ApoER2, Rabbit IgG
Synonyms
APOER2 antibody | Apolipoprotein E receptor 2 antibody | low density lipoprotein receptor-related protein 8 antibody | Low-density lipoprotein receptor-related protein 8 antibody | LRP-8 antibody | LRP8 antibody | LRP8_HUMAN antibody | LRP8 | MCI1 | LRP-8
Specifications & Purity
ExactAb™, Validated, KD, Recombinant, Lot by Lot
Host species
Rabbit
Specificity
ApoER2
Immunogen
A synthetic peptide derived from human ApoER2 (AA 900-963).
Positive Control
WB: SK-N-SH and C6 cell lysates.
Conjugation
Unconjugated
Grade
ExactAb™, KD Validation, Recombinant, Validated
Product Description
Rabbit anti Human ApoER2 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/2000 Protein Function: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Product Properties
Isotype
Rabbit IgG
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant ApoER2 Antibody (Ab089253) - Western Blot All lanes: Recombinant ApoER2 Antibody (Ab089253) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 106 kDa Observed band size: 95 kDa Exposure time: 39.9 s
Associated Targets(Human)
LRP8TbioLow-density lipoprotein receptor-related protein 8 (0 Activities)