| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab091675-10μl | 10μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $66.90 | |
| Ab091675-50μl | 50μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
| Ab091675-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab091675-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,699.90 |
Recombinant; Rabbit anti Human Brd4 Antibody; WB; Unconjugated
| Product Name | Recombinant Brd4 Antibody - Primary antibody, specific to BRD4, Rabbit IgG |
|---|---|
| Synonyms | Brd4 | BRD4_HUMAN | bromodomain containing protein 4 | Bromodomain-containing protein 4 | CAP | chromosome associated protein | HUNK1 | Protein HUNK1 | Brd4 antibody | BRD4-NUT FUSION antibody | BRD4-NUT fusion oncoprotein antibody | BRD4_HUMAN antibody | |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 0.8 mg/mL |
| Host species | Rabbit |
| Specificity | BRD4 |
| Immunogen | A synthetic peptide derived from human Brd4 (AA 140-210) |
| Positive Control | WB: HeLa, HEK293, Jurkat and MDA-MB-231 cell lysates. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description | Rabbit anti Human Brd4 Antibody, Recombinant, could be used for WB and so on. |
| Isotype | Rabbit IgG |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant Brd4 Antibody (Ab091675) - Western Blot
All lanes: Recombinant Brd4 Antibody (Ab091675) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 152 kDa
Observed band size: 102, 150 kDa
Exposure time: 4.8 s
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Application | Dilution info |
|---|---|
| WB | 1/500-1/1000"> 1/500-1/1000 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0607509 | Certificate of Analysis | Jun 27, 2024 | Ab091675 |
| ZJ24F0607508 | Certificate of Analysis | Jun 27, 2024 | Ab091675 |
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| 17. Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH et al.. (2016) Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.. J Med Chem, 59 (4): (1425-39). [PMID:25856009] [10.1021/op500134e] |
| 18. Demont EH, Chung CW, Furze RC, Grandi P, Michon AM, Wellaway C, Barrett N, Bridges AM, Craggs PD, Diallo H et al.. (2015) Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.. J Med Chem, 58 (14): (5649-73). [PMID:26155854] [10.1021/op500134e] |
| 19. McLure KG, Gesner EM, Tsujikawa L, Kharenko OA, Attwell S, Campeau E, Wasiak S, Stein A, White A, Fontano E et al.. (2013) RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.. PLoS ONE, 8 (12): (e83190). [PMID:24391744] [10.1021/op500134e] |
| 20. Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I et al.. (2014) [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.. J Med Chem, 57 (2): (462-76). [PMID:24313754] [10.1021/op500134e] |
| 21. Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D et al.. (2016) Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.. J Med Chem, 59 (10): (4462-75). [PMID:26914985] [10.1021/op500134e] |
| 22. Shortt J, Hsu AK, Martin BP, Doggett K, Matthews GM, Doyle MA, Ellul J, Jockel TE, Andrews DM, Hogg SJ et al.. (2014) The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound.. Cell Rep, 7 (4): (1009-19). [PMID:24813887] [10.1021/op500134e] |
| 23. Liu S, Yosief HO, Dai L, Huang H, Dhawan G, Zhang X, Muthengi AM, Roberts J, Buckley DL, Perry JA et al.. (2018) Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors.. J Med Chem, 61 (17): (7785-7795). [PMID:30125504] [10.1021/op500134e] |
| 24. Winter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ et al.. (2017) BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.. Mol Cell, 67 (1): (5-18.e19). [PMID:28673542] [10.1021/op500134e] |
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| 26. Chan KH, Zengerle M, Testa A, Ciulli A. (2018) Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.. J Med Chem, 61 (2): (504-513). [PMID:28595007] [10.1021/op500134e] |
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| 42. Baud MG, Lin-Shiao E, Zengerle M, Tallant C, Ciulli A.. (2016) New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.. J Med Chem, 59 (4): (1492-1500). [PMID:26367539] [10.1021/acs.jmedchem.5b01135] |
| 43. Palmer WS, Poncet-Montange G, Liu G, Petrocchi A, Reyna N, Subramanian G, Theroff J, Yau A, Kost-Alimova M, Bardenhagen JP, Leo E, Shepard HE, Tieu TN, Shi X, Zhan Y, Zhao S, Barton MC, Draetta G, Toniatti C, Jones P, Geck Do M, Andersen JN.. (2016) Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.. J Med Chem, 59 (4): (1440-1454). [PMID:26061247] [10.1021/acs.jmedchem.5b00405] |
| 44. Romero FA, Taylor AM, Crawford TD, Tsui V, Côté A, Magnuson S.. (2016) Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.. J Med Chem, 59 (4): (1271-1298). [PMID:26572217] [10.1021/acs.jmedchem.5b01514] |
| 45. Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Einsle O, Günther S, Wohlwend D.. (2016) 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).. J Med Chem, 59 (4): (1518-1530). [PMID:26731611] [10.1021/acs.jmedchem.5b01267] |
| 46. Sutherell CL, Tallant C, Monteiro OP, Yapp C, Fuchs JE, Fedorov O, Siejka P, Müller S, Knapp S, Brenton JD, Brennan PE, Ley SV.. (2016) Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.. J Med Chem, 59 (10): (5095-5101). [PMID:27119626] [10.1021/acs.jmedchem.5b01997] |
| 47. Ren C, Smith SG, Yap K, Li S, Li J, Mezei M, Rodriguez Y, Vincek A, Aguilo F, Walsh MJ, Zhou MM.. (2016) Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7.. ACS Med Chem Lett, 7 (6): (601-605). [PMID:27326334] [10.1021/acsmedchemlett.6b00042] |
| 48. Li J, Wang P, Zhou B, Shi J, Liu J, Li X, Fan L, Zheng Y, Ouyang L.. (2016) Development of 4,5-dihydro-benzodiazepinone derivatives as a new chemical series of BRD4 inhibitors.. Eur J Med Chem, 121 (294-299). [PMID:27266999] [10.1016/j.ejmech.2016.05.057] |
| 49. Myrianthopoulos V, Gaboriaud-Kolar N, Tallant C, Hall ML, Grigoriou S, Brownlee PM, Fedorov O, Rogers C, Heidenreich D, Wanior M, Drosos N, Mexia N, Savitsky P, Bagratuni T, Kastritis E, Terpos E, Filippakopoulos P, Müller S, Skaltsounis AL, Downs JA, Knapp S, Mikros E.. (2016) Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.. J Med Chem, 59 (19): (8787-8803). [PMID:27617704] [10.1021/acs.jmedchem.6b00355] |
| 50. Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, Kaufman S, Beresini MH, Liao J, Liu W, Chen KX, Chen Z, Conery AR, Côté A, Jayaram H, Jiang Y, Kiefer JR, Kleinheinz T, Li Y, Maher J, Pardo E, Poy F, Spillane KL, Wang F, Wang J, Wei X, Xu Z, Xu Z, Yen I, Zawadzke L, Zhu X, Bellon S, Cummings R, Cochran AG, Albrecht BK, Magnuson S.. (2016) Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.. J Med Chem, 59 (23): (10549-10563). [PMID:27682507] [10.1021/acs.jmedchem.6b01022] |
| 51. Sun Z, Zhang H, Chen Z, Xie Y, Jiang H, Chen L, Ding H, Zhang Y, Jiang H, Zheng M, Luo C.. (2017) Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.. Bioorg Med Chem Lett, 27 (9): (2003-2009). [PMID:28347667] [10.1016/j.bmcl.2017.03.012] |
| 52. Mao R, Shao J, Zhu K, Zhang Y, Ding H, Zhang C, Shi Z, Jiang H, Sun D, Duan W, Luo C.. (2017) Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.. J Med Chem, 60 (14): (6289-6304). [PMID:28650658] [10.1021/acs.jmedchem.7b00587] |
| 53. Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.. (2017) BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.. J Med Chem, 60 (12): (4805-4817). [PMID:28535045] [10.1021/acs.jmedchem.6b01336] |
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