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Recombinant Brd4 Antibody - Primary antibody, specific to BRD4, Rabbit IgG

ExactAb™
Recombinant
Validated
0.8 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human Brd4 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab091675

Grouped product items
SKU	Size	Availability	Price
Ab091675-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$66.90
Ab091675-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
Ab091675-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
Ab091675-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,699.90

Recombinant; Rabbit anti Human Brd4 Antibody; WB; Unconjugated

View related series

Accession#:O60885 Brd4 Gene ID:23476

Basic Description

Product Name	Recombinant Brd4 Antibody - Primary antibody, specific to BRD4, Rabbit IgG
Synonyms	Brd4 \| BRD4_HUMAN \| bromodomain containing protein 4 \| Bromodomain-containing protein 4 \| CAP \| chromosome associated protein \| HUNK1 \| Protein HUNK1 \| Brd4 antibody \| BRD4-NUT FUSION antibody \| BRD4-NUT fusion oncoprotein antibody \| BRD4_HUMAN antibody \|
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.8 mg/mL
Host species	Rabbit
Specificity	BRD4
Immunogen	A synthetic peptide derived from human Brd4 (AA 140-210)
Positive Control	WB: HeLa, HEK293, Jurkat and MDA-MB-231 cell lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human Brd4 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Plays a role in a process governing chromosomal dynamics during mitosis.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.8 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant Brd4 Antibody (Ab091675) - Western Blot
All lanes: Recombinant Brd4 Antibody (Ab091675) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 152 kDa
Observed band size: 102, 150 kDa
Exposure time: 4.8 s

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSPA1L Tbio Heat shock 70 kDa protein 1-like 0 Activities

Discover Target: HSPA1L

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMCP Tbio Sperm mitochondrial-associated cysteine-rich protein 0 Activities

Discover Target: SMCP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0607509	Certificate of Analysis	Jun 27, 2024	Ab091675
ZJ24F0607508	Certificate of Analysis	Jun 27, 2024	Ab091675

References

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55. Ouyang L, Zhang L, Liu J, Fu L, Yao D, Zhao Y, Zhang S, Wang G, He G, Liu B.. (2017) Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer.. J Med Chem, 60 (24): (9990-10012). [PMID:29172540]
56. Hasvold LA, Sheppard GS, Wang L, Fidanze SD, Liu D, Pratt JK, Mantei RA, Wada CK, Hubbard R, Shen Y, Lin X, Huang X, Warder SE, Wilcox D, Li L, Buchanan FG, Smithee L, Albert DH, Magoc TJ, Park CH, Petros AM, Panchal SC, Sun C, Kovar P, Soni NB, Elmore SW, Kati WM, McDaniel KF.. (2017) Methylpyrrole inhibitors of BET bromodomains.. Bioorg Med Chem Lett, 27 (10): (2225-2233). [PMID:28268136]
57. Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J.. (2017) Drug Discovery Targeting Bromodomain-Containing Protein 4.. J Med Chem, 60 (11): (4533-4558). [PMID:28195723]
58. Shao M, He L, Zheng L, Huang L, Zhou Y, Wang T, Chen Y, Shen M, Wang F, Yang Z, Chen L.. (2017) Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.. Bioorg Med Chem Lett, 27 (17): (4051-4055). [PMID:28765013]
59. Ali I, Lee J, Go A, Choi G, Lee K.. (2017) Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment.. Bioorg Med Chem Lett, 27 (20): (4606-4613). [PMID:28939121]
60. Crawford TD, Audia JE, Bellon S, Burdick DJ, Bommi-Reddy A, Côté A, Cummings RT, Duplessis M, Flynn EM, Hewitt M, Huang HR, Jayaram H, Jiang Y, Joshi S, Kiefer JR, Murray J, Nasveschuk CG, Neiss A, Pardo E, Romero FA, Sandy P, Sims RJ, Tang Y, Taylor AM, Tsui V, Wang J, Wang S, Wang Y, Xu Z, Zawadzke L, Zhu X, Albrecht BK, Magnuson SR, Cochran AG.. (2017) GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).. ACS Med Chem Lett, 8 (7): (737-741). [PMID:28740608]
61. Xiang Q, Wang C, Zhang Y, Xue X, Song M, Zhang C, Li C, Wu C, Li K, Hui X, Zhou Y, Smaill JB, Patterson AV, Wu D, Ding K, Xu Y.. (2018) Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.. Eur J Med Chem, 147 (238-252). [PMID:29448139]
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