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Recombinant c-Kit Antibody - Primary antibody, specific to C-Kit, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human c-Kit Antibody; WB, IHC; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
    Application:
  • IHC
  • WB
Item Number
Ab096640
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab096640-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
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Bulk Order  DATASHEET

Recombinant; Rabbit anti Human c-Kit Antibody; WB, IHC; Unconjugated

View related series
Click to view target information: KIT
Accession#:P10721 c-Kit CD117 Gene ID:3815 Kit

Basic Description

Product NameRecombinant c-Kit Antibody - Primary antibody, specific to C-Kit, Rabbit IgG
SynonymsC Kit antibody; c-Kit antibody; c-Kit Ligand antibody; CD117 antibody; Kit antibody; Kit Ligand antibody; KIT oncogene antibody; KIT proto oncogene receptor tyrosine kinase antibody; KIT_HUMAN antibody; Mast cell growth factor receptor antibody; Mast/stem
Specifications & PurityExactAb™, Validated, Recombinant, 1.055 mg/mL
Host speciesRabbit
SpecificityC-Kit
ImmunogenA synthetic peptide derived from human c-Kit (AA 926-976).
Positive ControlWB: HEK293, Jurkat, HeLa, K562 and HUVEC cell lysates. IHC: Human breast cancer tissue.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human c-Kit Antibody, Recombinant, could be used for WB, IHC and so on.
Application
WB: 1/500-1/1000
IHC: 1/50-1/100
Protein Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration1.055 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant c-Kit Antibody (Ab096640) - Western Blot
All lanes: Recombinant c-Kit Antibody (Ab096640) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 29 kDa
Observed band size: 34, 123, 142 kDa
Exposure time: 18.9 s

Recombinant c-Kit Antibody (Ab096640) - IHC
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant c-Kit Antibody (Ab096640). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Associated Targets(Human)

KIT Tclin Mast/stem cell growth factor receptor Kit (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KIT Tclin Stem cell growth factor receptor (10667 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT) (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin VHL/KIT (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin Protein cereblon/Stem cell growth factor receptor (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
WB

1/500-1/1000

IHC

1/50 - 1/100

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F1202136Certificate of AnalysisDec 20, 2023 Ab096640
ZJ23F1202135Certificate of AnalysisDec 20, 2023 Ab096640

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Immunohistochemical staining protocol for frozen samples (IHC-Fr)
Categories: Protocols
Tags:
IHC Monoclonal antibodies Immunohistochemistry Frozen section Recombinant Antibodies
Immunohistochemistry (IHC) staining antigen retrieval protocol
Categories: Protocols
Tags:
IHC Monoclonal antibodies Immunohistochemistry Recombinant Antibodies Antigen Retrieval

References

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280. Abrams, Tinya J TJ, Lee, Leslie B LB, Murray, Lesley J LJ, Pryer, Nancy K NK and Cherrington, Julie M JM..  (2003)  SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer..  Molecular cancer therapeutics,      [PMID:12748309]
281. Mol, Clifford D CD and 9 more authors..  (2003)  Structure of a c-kit product complex reveals the basis for kinase transactivation..  The Journal of biological chemistry,    (22):   [PMID:12824176]
282. Schueneman, Aaron J AJ and 7 more authors..  (2003)  SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models..  Cancer research,    (15):   [PMID:12873999]
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295. Schittenhelm, Marcus M MM and 9 more authors..  (2006)  Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies..  Cancer research,    (1):   [PMID:16397263]
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298. Millward, M J MJ and 11 more authors..  (2006)  The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study..  British journal of cancer,    (9):   [PMID:16969355]
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311. Jin, Pei P and 9 more authors..  (2008)  Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis..  Arthritis research & therapy,      [PMID:18593464]
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317. Neumann, Ingo I and 6 more authors..  (2010)  Retinoic acid enhances sensitivity of neuroblastoma cells for imatinib mesylate..  Pediatric blood & cancer,      [PMID:20658618]
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