Recombinant CD79b Antibody - Primary antibody, specific to CD79B, Rabbit IgG
Synonyms
AGM6 antibody | B cell antigen receptor complex associated protein beta chain antibody | B cell specific glycoprotein B29 antibody | B-cell antigen receptor complex-associated protein beta chain antibody | B-cell-specific glycoprotein B29 antibody | B29 a
Specifications & Purity
ExactAb™, Validated, Recombinant, 0.27 mg/mL
Host species
Rabbit
Specificity
CD79B
Immunogen
A synthetic peptide derived from human CD79b (AA 190-229)
Positive Control
WB: Mouse spleen, Ramos and Raji lysates.
Conjugation
Unconjugated
Grade
ExactAb™, Recombinant, Validated
Product Description
Rabbit anti Human CD79b Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500 - 1/1000 Protein Function Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Post-translational Phosphorylated on tyrosine upon B-cell activation.
Product Properties
Isotype
Rabbit IgG
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
0.27 mg/mL
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant CD79b Antibody (Ab095331) - Western Blot All lanes: Recombinant CD79b Antibody (Ab095331) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 26 kDa Observed band size: 15, 36 kDa Exposure time: 31.2 s
Associated Targets(Human)
CD79BTclinB-cell antigen receptor complex-associated protein beta chain (0 Activities)
1.Müller, B B, Cooper, L L and Terhorst, C C.. (1992) Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.. European journal of immunology, [PMID:1534761]
2.Vasile, S S, Coligan, J E JE, Yoshida, M M and Seon, B K BK.. (1994) Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.. Molecular immunology, [PMID:7514267]
3.Hashimoto, S S, Chiorazzi, N N and Gregersen, P K PK.. (1995) Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.. Molecular immunology, [PMID:7643857]
4.Hashimoto, S S, Chiorazzi, N N and Gregersen, P K PK.. (1994) The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.. Immunogenetics, [PMID:7913081]
5.Hashimoto, S S, Gregersen, P K PK and Chiorazzi, N N.. (1993) The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.. Journal of immunology (Baltimore, Md. : 1950), (15):[PMID:8419481]
6.Wood, W J WJ and 6 more authors.. (1993) Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).. Genomics, [PMID:8486355]
7.Dobbs, A Kerry and 5 more authors.. (2007) Cutting edge: a hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development.. Journal of immunology (Baltimore, Md. : 1950), (15):[PMID:17675462]
8.Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]
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