Recombinant CSN8 Antibody - Primary antibody, specific to CSN8, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human CSN8 Antibody; WB, IHC, ICC, IF; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • IF/ICC
  • IHC
  • WB
Item Number
Ab097958
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab097958-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab097958-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
Ab097958-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$319.90
Ab097958-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90

Recombinant; Rabbit anti Human CSN8 Antibody; WB, IHC, ICC, IF; Unconjugated

Basic Description

Product NameRecombinant CSN8 Antibody - Primary antibody, specific to CSN8, Rabbit IgG
SynonymsCOPS8 | COP9 | CSN8 | SGN8 | COP9 homolog antibody | COP9 signalosome complex subunit 8 antibody | COP9 signalosome subunit 8 antibody | Cops8 antibody | CSN8 antibody | CSN8_HUMAN antibody | hCOP9 antibody | JAB1 containing signalosome subunit 8 antibody
Specifications & PurityExactAb™, Validated, Recombinant, 0.2 mg/mL
Host speciesRabbit
SpecificityCSN8
ImmunogenA synthetic peptide derived from human COPS8 (AA 189-202)
Positive ControlWB: HeLa, K562, Hep G2, A375, NIH/3T3 and C6 cell lysates. IHC: Human breast cancer tissue. ICC/IF: HeLa cells.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human CSN8 Antibody, Recombinant, could be used for WB, IHC, ICC, IF and so on.
Application:
WB: 1/500-1/1000
IHC: 1/50-1/100
ICC/IF: 1/50-1/200
Protein Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodAntigen affinity purified
FormLiquid
Concentration0.2 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant CSN8 Antibody (Ab097958) - Western Blot
All lanes: Recombinant CSN8 Antibody (Ab097958) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 23 kDa
Observed band size: 21 kDa
Exposure time: 5.0 s

Associated Targets(Human)

COPS8 Tbio COP9 signalosome complex subunit 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
COPS8 Tbio COP9 signalosome complex subunit 8 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
WB

1/500-1/1000

ICC/IF

1/50-1/200

IHC

1/50 - 1/100

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0708994Certificate of AnalysisJul 31, 2024 Ab097958
ZJ24F0708993Certificate of AnalysisJul 31, 2024 Ab097958

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