Basic Description

Product Name	Recombinant D-Dimer Antibody - Primary antibody, for ELISA,CLIA,LF,GICA,Capture antibody,FIA various applications, from Human, generated in Mouse, specific to FGA, IgG2b
Specifications & Purity	ExactAb™, Validated, Carrier Free, Azide Free, Recombinant, Lot by Lot
Host Species	Mouse
Host species	Mouse
Specificity	FGA
Application	ELISA,CLIA,LF,GICA,Capture antibody,FIA
Immunogen	D-Dimer purifed from Human Plasma
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Product Description	Recombinant D-Dimer Antibody, 32D2, is a Capture antibody could be used for ELISA, CLIA at 1.0µg/mL; LF, GICA, FIA at 1mg/mL.

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	IgG2b
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Matched Pairs	[Ab008172] Recombinant D-Dimer Antibody as Detection antibody in ELISA, CLIA, LF, GICA, FIA
Source	CHO supernatant
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -20±5℃ for three years. Avoid freeze/thaw

Associated Targets(Human)

FGA Tbio Fibrinogen alpha chain (0 Activities)

Discover Target: FGA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Application

Application	Dilution info
CLIA	1 μg/mL

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0500225	Certificate of Analysis	Jun 02, 2023	Ab008121
ZJ23F0500227	Certificate of Analysis	Jun 02, 2023	Ab008121

References

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2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039] [10.1021/op500134e]
3. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]
4. Cottrell, B A BA, Strong, D D DD, Watt, K W KW and Doolittle, R F RF.. (1979) Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites.. Biochemistry, (27): [PMID:518845]
5. Watt, K W KW, Cottrell, B A BA, Strong, D D DD and Doolittle, R F RF.. (1979) Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence.. Biochemistry, (27): [PMID:518846]
6. Fretto, L J LJ, Ferguson, E W EW, Steinman, H M HM and McKee, P A PA.. (1978) Localization of the alpha-chain cross-link acceptor sites of human fibrin.. The Journal of biological chemistry, (10): [PMID:632262]
7. Blombäck, B B, Hessel, B B and Hogg, D D.. (1976) Disulfide bridges in nh2 -terminal part of human fibrinogen.. Thrombosis research, [PMID:936108]
8. Fu, Y Y and 8 more authors.. (1992) Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.. Biochemistry, (8): [PMID:1457396]
9. Martin, P D PD and 5 more authors.. (1992) The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.. The Journal of biological chemistry, (15): [PMID:1560020]
10. Maekawa, H H and 9 more authors.. (1992) Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator.. The Journal of clinical investigation, [PMID:1634621]
11. Maekawa, H H and 9 more authors.. (1991) An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation.. The Journal of biological chemistry, (25): [PMID:1675636]
12. Yoshida, N N and 5 more authors.. (1991) Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.. Blood, (1): [PMID:2070049]
13. Chung, D W DW, Harris, J E JE and Davie, E W EW.. (1990) Nucleotide sequences of the three genes coding for human fibrinogen.. Advances in experimental medicine and biology, [PMID:2102623]
14. Kimura, S S and Aoki, N N.. (1986) Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.. The Journal of biological chemistry, (25): [PMID:2877981]
15. Itarte, E E, Plana, M M, Guasch, M D MD and Martos, C C.. (1983) Phosphorylation of fibrinogen by casein kinase 1.. Biochemical and biophysical research communications, (16): [PMID:6318767]
16. and Doolittle, R F RF.. (1984) Fibrinogen and fibrin.. Annual review of biochemistry, [PMID:6383194]
17. Kant, J A JA, Lord, S T ST and Crabtree, G R GR.. (1983) Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6575389]
18. Chung, D W DW, Rixon, M W MW, Que, B G BG and Davie, E W EW.. (1983) Cloning of fibrinogen genes and their cDNA.. Annals of the New York Academy of Sciences, (27): [PMID:6575700]
19. Rixon, M W MW, Chan, W Y WY, Davie, E W EW and Chung, D W DW.. (1983) Characterization of a complementary deoxyribonucleic acid coding for the alpha chain of human fibrinogen.. Biochemistry, (21): [PMID:6688355]
20. Imam, A M AM, Eaton, M A MA, Williamson, R R and Humphries, S S.. (1983) Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen.. Nucleic acids research, (11): [PMID:6689067]
21. Merlini, P A PA and 8 more authors.. (1995) Thrombin generation and activity during thrombolysis and concomitant heparin therapy in patients with acute myocardial infarction.. Journal of the American College of Cardiology, [PMID:7798503]
22. Benson, M D MD, Liepnieks, J J, Uemichi, T T, Wheeler, G G and Correa, R R.. (1993) Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.. Nature genetics, [PMID:8097946]
23. Yamazumi, K K and 5 more authors.. (1993) Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution.. Surgery today, [PMID:8461606]
24. Koopman, J J and 9 more authors.. (1993) Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.. The Journal of clinical investigation, [PMID:8473507]
25. Brennan, S O SO, Hammonds, B B and George, P M PM.. (1995) Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A alpha 20 Val --> Asp).. The Journal of clinical investigation, [PMID:8675656]
26. Spraggon, G G, Everse, S J SJ and Doolittle, R F RF.. (1997) Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.. Nature, (2): [PMID:9333233]
27. Everse, S J SJ, Spraggon, G G, Veerapandian, L L, Riley, M M and Doolittle, R F RF.. (1998) Crystal structure of fragment double-D from human fibrin with two different bound ligands.. Biochemistry, (16): [PMID:9628725]
28. Spraggon, G G and 7 more authors.. (1998) Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.. Proceedings of the National Academy of Sciences of the United States of America, (4): [PMID:9689040]
29. Everse, S J SJ, Spraggon, G G, Veerapandian, L L and Doolittle, R F RF.. (1999) Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.. Biochemistry, (9): [PMID:10074346]
30. Cargill, M M and 17 more authors.. (1999) Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nature genetics, [PMID:10391209]
31. Palma, M M, Shannon, O O, Quezada, H C HC, Berg, A A and Flock, J I JI.. (2001) Extracellular fibrinogen-binding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding to the alpha-chain.. The Journal of biological chemistry, (24): [PMID:11418620]
32. Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
33. Beranova-Giorgianni, Sarka S, Zhao, Yingxin Y, Desiderio, Dominic M DM and Giorgianni, Francesco F.. (2006) Phosphoproteomic analysis of the human pituitary.. Pituitary, [PMID:16807684]
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36. Zahedi, René P RP and 8 more authors.. (2008) Phosphoproteome of resting human platelets.. Journal of proteome research, [PMID:18088087]
37. Longstaff, C C, Williams, S S and Thelwell, C C.. (2008) Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy.. Cardiovascular & hematological agents in medicinal chemistry, [PMID:18673235]
38. Melandri, Giovanni G and 5 more authors.. (2009) Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction.. Vascular health and risk management, [PMID:19436656]
39. Ono, Masaya M and 23 more authors.. (2009) Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.. The Journal of biological chemistry, (16): [PMID:19696023]
40. Bian, Yangyang Y and 9 more authors.. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.. Journal of proteomics, (16): [PMID:24275569]
41. Ko, Ya-Ping YP and 9 more authors.. (2013) Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.. PLoS pathogens, [PMID:24348255]
42. Asselta, Rosanna R and 10 more authors.. (2015) Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.. Thrombosis and haemostasis, [PMID:25427968]
43. Palta, Sanjeev; Saroa, Richa and Palta, Anshu.. (2014) Overview of the coagulation system.. Indian journal of anaesthesia, [PMID:25535411]
44. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]

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SKU	Size	Availability	Price
Ab008121-10μg	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$29.90
Ab008121-50μg	50μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$87.90
Ab008121-100μg	100μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$117.90
Ab008121-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$327.90

Recombinant D-Dimer Antibody - Primary antibody, for ELISA,CLIA,LF,GICA,Capture antibody,FIA various applications, from Human, generated in Mouse, specific to FGA, IgG2b