| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab108929-10μl | 10μl | In stock | $66.90 | |
| Ab108929-50μl | 50μl | In stock | $199.90 | |
| Ab108929-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $279.90 | |
| Ab108929-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,699.90 |
Recombinant; Rabbit anti Human Hsp90 Antibody; WB, IF, ICC; Unconjugated
| Product Name | Recombinant Hsp90 Antibody - Primary antibody, specific to HSP90AA1, Rabbit IgG |
|---|---|
| Specifications & Purity | ExactAb™, Validated, Recombinant, 0.25 mg/mL |
| Host species | Rabbit |
| Specificity | HSP90AA1 |
| Immunogen | A synthetic peptide derived from human Hsp90 alpha (AA 1-52) |
| Positive Control | WB: Jurkat, Hep G2, K562, LNCaP, MCF7, A549, HeLa, NIH/3T3 and C6 cell lysates. ICC/IF: HeLa cells. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description | Rabbit anti Human Hsp90 Antibody, Recombinant, could be used for WB, IF, ICC and so on. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant Hsp90 Antibody (Ab108929) - Western Blot
All lanes: Recombinant Hsp90 Antibody (Ab108929) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 85 kDa
Observed band size: 89 kDa
Exposure time: 13.5 s
Recombinant Hsp90 Antibody (Ab108929) - IF/ICC
Immunofluorescence analysis of Hsp90 alpha in HeLa using Recombinant Hsp90 Antibody (Ab108929), and cells were counterstained with DAPI (blue).
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| IF/ICC |
1/50-1/200
">
1/50-1/200
|
| WB | 1/1000 - 1/2000"> 1/1000 - 1/2000 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0303360 | Certificate of Analysis | Mar 19, 2024 | Ab108929 |
| ZJ24F0303361 | Certificate of Analysis | Mar 19, 2024 | Ab108929 |
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| 13. Jason Davenport,Jacob R Manjarrez,Laura Peterson,Brian Krumm,Brian S J Blagg,Robert L Matts. (2011-04-14) Gambogic acid, a natural product inhibitor of Hsp90.. Journal of natural products, 74 ((5)): (1085-1092). [PMID:21486005] |
| 14. Yoshinori Asano,Tatsuya Kawase,Atsushi Okabe,Shuichi Tsutsumi,Hitoshi Ichikawa,Satoko Tatebe,Issay Kitabayashi,Fumio Tashiro,Hideo Namiki,Tadashi Kondo,Kentaro Semba,Hiroyuki Aburatani,Yoichi Taya,Hitoshi Nakagama,Rieko Ohki. (2016-01-13) IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.. Scientific reports, 6 (19174-19174). [PMID:26754925] |
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| 19. Ganesh T, Thepchatri P, Li L, Du Y, Fu H, Snyder JP, Sun A.. (2008) Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.. Bioorg Med Chem Lett, 18 (18): (4982-4987). [PMID:18762423] [10.1016/j.bmcl.2008.08.022] |
| 20. Hadden MK, Hill SA, Davenport J, Matts RL, Blagg BS.. (2009) Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.. Bioorg Med Chem, 17 (2): (634-640). [PMID:19101151] [10.1016/j.bmc.2008.11.064] |
| 21. Alexander LD, Sellers RP, Davis MR, Ardi VC, Johnson VA, Vasko RC, McAlpine SR.. (2009) Evaluation of di-sansalvamide A derivatives: synthesis, structure-activity relationship, and mechanism of action.. J Med Chem, 52 (24): (7927-7930). [PMID:20014866] [10.1021/jm901566c] |
| 22. Musso L, Dallavalle S, Merlini L, Bava A, Nasini G, Penco S, Giannini G, Giommarelli C, De Cesare A, Zuco V, Vesci L, Pisano C, Castorina M, Milazzo F, Cervoni ML, Dal Piaz F, De Tommasi N, Zunino F.. (2010) Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.. Bioorg Med Chem, 18 (16): (6031-6043). [PMID:20655237] [10.1016/j.bmc.2010.06.068] |
| 23. Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS.. (2011) A systematic protocol for the characterization of Hsp90 modulators.. Bioorg Med Chem, 19 (1): (684-692). [PMID:21129982] [10.1016/j.bmc.2010.10.029] |
| 24. Zehnder L, Bennett M, Meng J, Huang B, Ninkovic S, Wang F, Braganza J, Tatlock J, Jewell T, Zhou JZ, Burke B, Wang J, Maegley K, Mehta PP, Yin MJ, Gajiwala KS, Hickey MJ, Yamazaki S, Smith E, Kang P, Sistla A, Dovalsantos E, Gehring MR, Kania R, Wythes M, Kung PP.. (2011) Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.. J Med Chem, 54 (9): (3368-3385). [PMID:21438541] [10.1021/jm200128m] |
| 25. Zhao H, Donnelly AC, Kusuma BR, Brandt GE, Brown D, Rajewski RA, Vielhauer G, Holzbeierlein J, Cohen MS, Blagg BS.. (2011) Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.. J Med Chem, 54 (11): (3839-3853). [PMID:21553822] [10.1021/jm200148p] |
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| 32. Kusuma BR, Zhang L, Sundstrom T, Peterson LB, Dobrowsky RT, Blagg BS.. (2012) Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity.. J Med Chem, 55 (12): (5797-5812). [PMID:22702513] [10.1021/jm300544c] |
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| 40. Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y.. (2014) Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.. Eur J Med Chem, 87 (346-363). [PMID:25277067] [10.1016/j.ejmech.2014.09.078] |
| 41. Chen D, Shen A, Li J, Shi F, Chen W, Ren J, Liu H, Xu Y, Wang X, Yang X, Sun Y, Yang M, He J, Wang Y, Zhang L, Huang M, Geng M, Xiong B, Shen J.. (2014) Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.. Eur J Med Chem, 87 (765-781). [PMID:25313505] [10.1016/j.ejmech.2014.09.065] |
| 42. Meng T, Zhang D, Xie Z, Yu T, Wu S, Wyder L, Regenass U, Hilpert K, Huang M, Geng M, Shen J.. (2014) Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.. J Med Chem, 57 (23): (9832-9843). [PMID:25383915] [10.1021/jm5010144] |
| 43. Zhao H, Garg G, Zhao J, Moroni E, Girgis A, Franco LS, Singh S, Colombo G, Blagg BS.. (2015) Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors.. Eur J Med Chem, 89 (442-466). [PMID:25462258] [10.1016/j.ejmech.2014.10.034] |
| 44. Cervi G, Magnaghi P, Asa D, Avanzi N, Badari A, Borghi D, Caruso M, Cirla A, Cozzi L, Felder E, Galvani A, Gasparri F, Lomolino A, Magnuson S, Malgesini B, Motto I, Pasi M, Rizzi S, Salom B, Sorrentino G, Troiani S, Valsasina B, O'Brien T, Isacchi A, Donati D, D'Alessio R.. (2014) Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.. J Med Chem, 57 (24): (10443-10454). [PMID:25474526] [10.1021/jm501313x] |
| 45. Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS.. (2014) Development of radamide analogs as Grp94 inhibitors.. Bioorg Med Chem, 22 (15): (4083-4098). [PMID:25027801] [10.1016/j.bmc.2014.05.075] |
| 46. Schiemann K, Mallinger A, Wienke D, Esdar C, Poeschke O, Busch M, Rohdich F, Eccles SA, Schneider R, Raynaud FI, Czodrowski P, Musil D, Schwarz D, Urbahns K, Blagg J.. (2016) Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.. Bioorg Med Chem Lett, 26 (5): (1443-1451). [PMID:26852363] [10.1016/j.bmcl.2016.01.062] |
| 47. Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS.. (2016) Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.. J Med Chem, 59 (7): (3471-3488). [PMID:27003516] [10.1021/acs.jmedchem.6b00085] |
| 48. Montoir D, Barillé-Nion S, Tonnerre A, Juin P, Duflos M, Bazin MA.. (2016) Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90.. Eur J Med Chem, 119 (17-33). [PMID:27153346] [10.1016/j.ejmech.2016.04.050] |
| 49. Liang C, Hao H, Wu X, Li Z, Zhu J, Lu C, Shen Y.. (2016) Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors.. Eur J Med Chem, 121 (272-282). [PMID:27266997] [10.1016/j.ejmech.2016.05.033] |
| 50. Kim HS, Hong M, Ann J, Yoon S, Nguyen CT, Lee SC, Lee HY, Suh YG, Seo JH, Choi H, Kim JY, Kim KW, Kim J, Kim YM, Park SJ, Park HJ, Lee J.. (2016) Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors.. Bioorg Med Chem, 24 (22): (6082-6093). [PMID:27745993] [10.1016/j.bmc.2016.09.067] |
| 51. Malhotra S, Karanicolas J.. (2017) When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?. J Med Chem, 60 (1): (128-145). [PMID:27982595] [10.1021/acs.jmedchem.6b00725] |
| 52. Koca İ, Özgür A, Er M, Gümüş M, Açikalin Coşkun K, Tutar Y.. (2016) Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis.. Eur J Med Chem, 122 (280-290). [PMID:27376491] [10.1016/j.ejmech.2016.06.032] |
| 53. Huang R, Ayine-Tora DM, Muhammad Rosdi MN, Li Y, Reynisson J, Leung IKH.. (2017) Virtual screening and biophysical studies lead to HSP90 inhibitors.. Bioorg Med Chem Lett, 27 (2): (277-281). [PMID:27913182] [10.1016/j.bmcl.2016.11.059] |
| 54. Garg G, Zhao H, Blagg BS.. (2017) Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors.. Bioorg Med Chem, 25 (2): (451-457). [PMID:27914946] [10.1016/j.bmc.2016.11.030] |
| 55. Jeong JH, Oh YJ, Lho Y, Park SY, Liu KH, Ha E, Seo YH.. (2016) Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide.. Eur J Med Chem, 124 (1069-1080). [PMID:27783977] [10.1016/j.ejmech.2016.10.038] |
| 56. Goswami M, Wilke KE, Carlson EE.. (2017) Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.. J Med Chem, 60 (19): (8170-8182). [PMID:28933546] [10.1021/acs.jmedchem.7b01066] |
| 57. Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT.. (2018) Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.. J Med Chem, 61 (7): (2793-2805). [PMID:29528635] [10.1021/acs.jmedchem.7b01608] |
| 58. Kanwar A, Eduful BJ, Barbeto L, Carletti Bonomo P, Lemus A, Vesely BA, Mutka TS, Azhari A, Kyle DE, Leahy JW.. (2017) Synthesis and Activity of a New Series of Antileishmanial Agents.. ACS Med Chem Lett, 8 (8): (797-801). [PMID:28835791] [10.1021/acsmedchemlett.7b00039] |
| 59. Forsberg LK, Davis RE, Wimalasena VK, Blagg BSJ.. (2018) Exploiting polarity and chirality to probe the Hsp90 C-terminus.. Bioorg Med Chem, 26 (12): (3096-3110). [PMID:29720349] [10.1016/j.bmc.2018.04.028] |
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