Basic Description

Product Name	Recombinant Hsp90 Antibody - Primary antibody, specific to HSP90AA1, Rabbit IgG
Synonyms	FLJ31884; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock prot
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.25 mg/mL
Host species	Rabbit
Specificity	HSP90AA1
Immunogen	A synthetic peptide derived from human Hsp90 alpha (AA 1-52)
Positive Control	WB: Jurkat, Hep G2, K562, LNCaP, MCF7, A549, HeLa, NIH/3T3 and C6 cell lysates. ICC/IF: HeLa cells.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human Hsp90 Antibody, Recombinant, could be used for WB, IF, ICC and so on. Application: WB: 1/500-1/2000 ICC/IF: 1/50-1/200 Protein function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Product Properties

Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.25 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant Hsp90 Antibody (Ab108929) - Western Blot
All lanes: Recombinant Hsp90 Antibody (Ab108929) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 85 kDa
Observed band size: 89 kDa
Exposure time: 13.5 s

Recombinant Hsp90 Antibody (Ab108929) - IF/ICC
Immunofluorescence analysis of Hsp90 alpha in HeLa using Recombinant Hsp90 Antibody (Ab108929), and cells were counterstained with DAPI (blue).
.

Associated Targets(Human)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha (0 Activities)

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/2000
ICC/IF	1/50-1/200

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0303360	Certificate of Analysis	Mar 19, 2024	Ab108929
ZJ24F0303361	Certificate of Analysis	Mar 19, 2024	Ab108929

References

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57. Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT.. (2018) Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.. J Med Chem, 61 (7): (2793-2805). [PMID:29528635]
58. Kanwar A, Eduful BJ, Barbeto L, Carletti Bonomo P, Lemus A, Vesely BA, Mutka TS, Azhari A, Kyle DE, Leahy JW.. (2017) Synthesis and Activity of a New Series of Antileishmanial Agents.. ACS Med Chem Lett, 8 (8): (797-801). [PMID:28835791]
59. Forsberg LK, Davis RE, Wimalasena VK, Blagg BSJ.. (2018) Exploiting polarity and chirality to probe the Hsp90 C-terminus.. Bioorg Med Chem, 26 (12): (3096-3110). [PMID:29720349]
60. Jiang F, Guo AP, Xu JC, Wang HJ, Mo XF, You QD, Xu XL.. (2017) Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors.. Eur J Med Chem, 141 (1-14). [PMID:29028527]
61. Khandelwal A, Crowley VM, Blagg BSJ.. (2017) Resorcinol-Based Grp94-Selective Inhibitors.. ACS Med Chem Lett, 8 (10): (1013-1018). [PMID:29057043]
62. Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE.. (2018) Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).. J Med Chem, 61 (14): (6163-6177). [PMID:29953808]
63. Liang C, Wu X, Li Z, Zhu J, Lu C, Shen Y.. (2018) Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors.. Eur J Med Chem, 143 (85-96). [PMID:29172085]
64. Wei Q, Ning JY, Dai X, Gao YD, Su L, Zhao BX, Miao JY.. (2018) Discovery of novel HSP90 inhibitors that induced apoptosis and impaired autophagic flux in A549 lung cancer cells.. Eur J Med Chem, 145 (551-558). [PMID:29339250]
65. Forsberg LK, Liu W, Holzbeierlein J, Blagg BSJ.. (2017) Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancer.. Bioorg Med Chem Lett, 27 (18): (4514-4519). [PMID:28844386]
66. Ojha R, Huang HL, HuangFu WC, Wu YW, Nepali K, Lai MJ, Su CJ, Sung TY, Chen YL, Pan SL, Liou JP.. (2018) 1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.. Eur J Med Chem, 150 (667-677). [PMID:29567459]
67. Ferraro M, D'Annessa I, Moroni E, Morra G, Paladino A, Rinaldi S, Compostella F, Colombo G.. (2018) Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design.. J Med Chem, 62 (1): (60-87). [PMID:30048133]
68. Yao H, Xu F, Wang G, Xie S, Li W, Yao H, Ma C, Zhu Z, Xu J, Xu S.. (2019) Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.. Eur J Med Chem, 167 (485-498). [PMID:30784881]
69. Wang L, Jiang J, Zhang L, Zhang Q, Zhou J, Li L, Xu X, You Q.. (2020) Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.. J Med Chem, 63 (3): (1281-1297). [PMID:31935086]
70. Li L, Wang L, You QD, Xu XL.. (2020) Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.. J Med Chem, 63 (5): (1798-1822). [PMID:31663736]
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Recombinant Hsp90 Antibody - Primary antibody, specific to HSP90AA1, Rabbit IgG