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Recombinant IL-15RA Antibody - Primary antibody, specific to IL15RA, Rabbit IgG

  • ExactAb™
  • Recombinant
  • Validated
  • 1.0 mg/mL
Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human IL-15RA Antibody; WB; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
    Application:
  • WB
Item Number
Ab109944
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab109944-10μl
10μl
In stock
$66.90
Ab109944-50μl
50μl
In stock
$199.90
Ab109944-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab109944-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90

Recombinant; Rabbit anti Human IL-15RA Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant IL-15RA Antibody - Primary antibody, specific to IL15RA, Rabbit IgG
SynonymsAA690181 antibody; CD215 antibody; I15RA_HUMAN antibody; IL 15R alpha antibody; IL-15 receptor subunit alpha antibody; IL-15R-alpha antibody; IL-15RA antibody; Il15ra antibody; Interleukin 15 receptor alpha antibody; Interleukin 15 receptor subunit alpha
Specifications & PurityExactAb™, Validated, Recombinant, 1.0 mg/mL
Host speciesRabbit
SpecificityIL15RA
ImmunogenA synthetic peptide derived from human IL15RA (AA 118-202)
Positive ControlWB: Raji lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human IL-15RA Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500 - 1/1000
Protein Function
Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration1.0 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant IL-15RA Antibody (Ab109944) - Western Blot
All lanes: Recombinant IL-15RA Antibody (Ab109944) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 28 kDa
Observed band size: 42 kDa
Exposure time: 200.0 s

Associated Targets

IL15RA Tbio Interleukin-15 receptor subunit alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0505751Certificate of AnalysisMay 16, 2024 Ab109944
ZJ24F0505750Certificate of AnalysisMay 16, 2024 Ab109944

Related Documents

References

1. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA et al..  (1995)  Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes..  J Biol Chem,  270  (50): (29862-9).  [PMID:8530383]
2. Quéméner A, Maillasson M, Arzel L, Sicard B, Vomiandry R, Mortier E, Dubreuil D, Jacques Y, Lebreton J, Mathé-Allainmat M.  (2017)  Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization..  J Med Chem,  60  (14): (6249-6272).  [PMID:28657314]
3. Zhu X, Marcus WD, Xu W, Lee HI, Han K, Egan JO, Yovandich JL, Rhode PR, Wong HC.  (2009)  Novel human interleukin-15 agonists..  J Immunol,  183  (6): (3598-607).  [PMID:19710453]
4. Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA et al..  (2011)  IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization..  Cytokine,  56  (3): (804-10).  [PMID:22019703]
5. Żyżyńska-Granica B, Trzaskowski B, Niewieczerzał S, Filipek S, Zegrocka-Stendel O, Dutkiewicz M, Krzeczyński P, Kowalewska M, Koziak K..  (2017)  Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors..  Eur J Med Chem,  136  (543-547).  [PMID:28535470]
6. Yu, W W and 9 more authors..  (1997)  Large-scale concatenation cDNA sequencing..  Genome research,      [PMID:9110174]
7. Dubois, S S and 9 more authors..  (1999)  Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression..  The Journal of biological chemistry,    (17):   [PMID:10480910]
8. Bulanova, E E and 6 more authors..  (2001)  The IL-15R alpha chain signals through association with Syk in human B cells..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:11714793]
9. Kurowska, M M, Rudnicka, W W, Maślińska, D D and Maśliński, W W..  (2002)  Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain..  Annals of the New York Academy of Sciences,      [PMID:12114302]
10. Bernard, Jérôme J and 11 more authors..  (2004)  Identification of an interleukin-15alpha receptor-binding site on human interleukin-15..  The Journal of biological chemistry,    (4):   [PMID:15039446]
11. Ratthé, Claude C and Girard, Denis D..  (2004)  Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain..  Journal of leukocyte biology,      [PMID:15123770]
12. Deloukas, P P and 135 more authors..  (2004)  The DNA sequence and comparative analysis of human chromosome 10..  Nature,    (27):   [PMID:15164054]
13. Mortier, Erwan E, Bernard, Jérôme J, Plet, Ariane A and Jacques, Yannick Y..  (2004)  Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:15265897]
14. Lorenzen, Inken I, Dingley, Andrew J AJ, Jacques, Yannick Y and Grötzinger, Joachim J..  (2006)  The structure of the interleukin-15 alpha receptor and its implications for ligand binding..  The Journal of biological chemistry,    (10):   [PMID:16377614]

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