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Recombinant Integrin beta 1 Antibody - Primary antibody, specific to ITGB1, Rabbit IgG

ExactAb™
Recombinant
Validated
0.4 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human Integrin beta 1 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab110850

Grouped product items
SKU	Size	Availability	Price
Ab110850-10μl	10μl	In stock	$66.90
Ab110850-50μl	50μl	In stock	$189.90
Ab110850-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
Ab110850-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,699.90

Recombinant; Rabbit anti Human Integrin beta 1 Antibody; WB; Unconjugated

View related series

Accession#:P05556 Gene ID:3688 Integrin beta 1 ITGB1

Basic Description

Product Name	Recombinant Integrin beta 1 Antibody - Primary antibody, specific to ITGB1, Rabbit IgG
Synonyms	beta1 integrin antibody; CD_antigen=CD29 antibody; CD29 antibody; Fibronectin receptor subunit beta antibody; FNRB antibody; Glycoprotein IIa antibody; GP IIa antibody; GPIIA antibody; Integrin beta-1 antibody; Integrin subunit beta 1 antibody; integrin V
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.4 mg/mL
Host species	Rabbit
Specificity	ITGB1
Immunogen	Recombinant protein of human Integrin beta 1 (AA 21-220).
Positive Control	WB: A459, A431, HeLa, NIH/3T3 and C6 cell lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human Integrin beta 1 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Isoform 5: Isoform 5 displaces isoform 1 in striated muscles. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).

Product Properties

Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Antigen affinity purified
Form	Liquid
Concentration	0.4 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant Integrin beta 1 Antibody (Ab110850) - Western Blot
All lanes: Recombinant Integrin beta 1 Antibody (A11b0850) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 88 kDa
Observed band size: 88-140 kDa
Exposure time: 52.9 s

Recombinant Integrin beta 1 Antibody (Ab110850) - Western Blot
All lanes: Recombinant Integrin beta 1 Antibody (Ab110850) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 88 kDa
Observed band size: 88-140 kDa
Exposure time: 205.9 s

Associated Targets

ITGB1 Tclin Integrin beta-1 0 Activities

Discover Target: ITGB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/1000

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0303367	Certificate of Analysis	Mar 19, 2024	Ab110850
ZJ24F0303366	Certificate of Analysis	Mar 19, 2024	Ab110850

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References

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71. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2012) Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:23125415]
72. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): [PMID:23186163]
73. Liu, Weizhi W, Draheim, Kyle M KM, Zhang, Rong R, Calderwood, David A DA and Boggon, Titus J TJ.. (2013) Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.. Molecular cell, (21): [PMID:23317506]
74. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2014) The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.. PloS one, [PMID:24789099]
75. Muharram, Ghaffar G and 8 more authors.. (2014) Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells.. Developmental cell, (27): [PMID:24814316]
76. Fujita, Masaaki M and 7 more authors.. (2015) Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.. The Journal of biological chemistry, (2): [PMID:25398877]
77. Takada, Yoko K YK and 5 more authors.. (2017) Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.. The Journal of biological chemistry, (8): [PMID:29030430]
78. Takada, Yoko K; Yu, Jessica; Shimoda, Michiko and Takada, Yoshikazu.. (2019) Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:31331973]
79. Alqarihi, Abdullah and 10 more authors.. (2020) GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.. mBio, (2): [PMID:32487760]
80. Beddingfield, Brandon J and 7 more authors.. (2021) The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.. JACC. Basic to translational science, [PMID:33102950]

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