Recombinant IRF4 Antibody - Primary antibody, specific to IRF4, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human IRF4 Antibody; WB; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
    Application:
  • WB
Item Number
Ab116484
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab116484-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab116484-50μl
50μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$199.90
Ab116484-100μl
100μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$299.90
Ab116484-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90

Recombinant; Rabbit anti Human IRF4 Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant IRF4 Antibody - Primary antibody, specific to IRF4, Rabbit IgG
SynonymsInterferon regulatory factor 4 antibody; IRF 4 antibody; IRF-4 antibody; Irf4 antibody; IRF4_HUMAN antibody; LSIRF antibody; Lymphocyte specific interferon regulatory factor antibody; Lymphocyte specific IRF antibody; Lymphocyte-specific interferon regula
Specifications & PurityExactAb™, Validated, Recombinant, High performance, 0.25 mg/mL
Host speciesRabbit
SpecificityIRF4
ImmunogenA synthetic peptide derived from human MUM1 (AA 144-450).
Positive ControlWB: Ramos cell lysate.
ConjugationUnconjugated
GradeExactAb™, High Performance, Recombinant, Validated
Product Description

Rabbit anti Human IRF4 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500 – 1/10000
Protein Function
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.25 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant IRF4 Antibody (Ab116484) - Western Blot
All lanes: Recombinant IRF4 Antibody (Ab116484) at 1/10000 dilution
Samples: Lysates at 10 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution

Predicted band size: 52 kDa
Observed band size: 50 kDa
Exposure time: 76.6 s

Associated Targets(Human)

IRF4 Tbio Interferon regulatory factor 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/10000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F1001405Certificate of AnalysisOct 26, 2023 Ab116484
ZJ23F1001406Certificate of AnalysisOct 26, 2023 Ab116484

Related Documents

References

1. Grossman, A A and 9 more authors..  (1996)  Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25..  Genomics,    (15):   [PMID:8921401]
2. Iida, S S and 7 more authors..  (1997)  Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma..  Nature genetics,      [PMID:9326949]
3. Rao, S S, Matsumura, A A, Yoon, J J and Simon, M C MC..  (1999)  SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1..  The Journal of biological chemistry,    (16):   [PMID:10196196]
4. Gupta, Sanjay S and 6 more authors..  (2003)  Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system..  Human immunology,      [PMID:12651066]
5. Han, Jiali J and 16 more authors..  (2008)  A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation..  PLoS genetics,    (16):   [PMID:18483556]
6. Praetorius, Christian and 32 more authors..  (2013)  A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway..  Cell,    (21):   [PMID:24267888]

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