Basic Description

Product Name	Recombinant JAB1 Antibody - Primary antibody, specific to JAB1, Rabbit IgG
Synonyms	38 kDa Mov34 homolog antibody \| COP9 (constitutive photomorphogenic) homolog subunit 5 antibody \| COP9 constitutive photomorphogenic homolog subunit 5 antibody \| COP9 signalosome complex subunit 5 antibody \| COP9 signalosome subunit 5 antibody \| Cop9 subu
Specifications & Purity	Recombinant, ExactAb™, Validated, 0.7 mg/mL
Biochemical and Physiological Mechanisms	Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the
Host species	Rabbit
Specificity	JAB1
Immunogen	A synthetic peptide derived from human JAB1
Positive Control	WB: U-2 OS, MCF7, HeLa and C6 cell lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human JAB1 Antibody, Recombinant, could be used for WB and so on.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.7 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

COPS5 Tchem COP9 signalosome complex subunit 5 (0 Activities)

Discover Target: COPS5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Application

Application	Dilution info
WB	1/2000 "> 1/2000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Lei Fang,Xiaorong Wang,Kosj Yamoah,Phang-lang Chen,Zhen-Qiang Pan,Lan Huang. (2008-10-15) Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.. Journal of proteome research, 7 ((11)): (4914-4925). [PMID:18850735]
2. Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM.. (2017) Discovery of an Inhibitor of the Proteasome Subunit Rpn11.. J Med Chem, 60 (4): (1343-1361). [PMID:28191850] [10.1021/acs.jmedchem.6b01379]
3. Claret, F X FX, Hibi, M M, Dhut, S S, Toda, T T and Karin, M M.. (1996) A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.. Nature, (3): [PMID:8837781]
4. Asano, K K and 5 more authors.. (1997) Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.. The Journal of biological chemistry, (24): [PMID:9341143]
5. Seeger, M M and 8 more authors.. (1998) A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:9535219]
6. Dechend, R R and 7 more authors.. (1999) The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.. Oncogene, (3): [PMID:10362352]
7. Chauchereau, A A, Georgiakaki, M M, Perrin-Wolff, M M, Milgrom, E E and Loosfelt, H H.. (2000) JAB1 interacts with both the progesterone receptor and SRC-1.. The Journal of biological chemistry, (24): [PMID:10722692]
8. Bianchi, E E and 7 more authors.. (2000) Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.. Nature, (6): [PMID:10766246]
9. Kleemann, R R and 13 more authors.. (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.. Nature, (9): [PMID:11089976]
10. Bech-Otschir, D D and 6 more authors.. (2001) COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.. The EMBO journal, (2): [PMID:11285227]
11. Lyapina, S S and 9 more authors.. (2001) Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.. Science (New York, N.Y.), (18): [PMID:11337588]
12. Lu, Chengrong C and 14 more authors.. (2002) Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:11709497]
13. Wan, Mei M and 7 more authors.. (2002) Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation.. EMBO reports, [PMID:11818334]
14. Caballero, Otávia L OL and 9 more authors.. (2002) Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).. Oncogene, (2): [PMID:12082530]
15. Uhle, Stefan S and 10 more authors.. (2003) Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.. The EMBO journal, (17): [PMID:12628923]
16. Groisman, Regina R and 8 more authors.. (2003) The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.. Cell, (2): [PMID:12732143]
17. Zou, Yonglong Y, Lim, Seunghwan S, Lee, Kangmoon K, Deng, Xiaobing X and Friedman, Eileen E.. (2003) Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.. The Journal of biological chemistry, (5): [PMID:14500717]
18. Kim, Byung-Chul BC and 8 more authors.. (2004) Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation.. Molecular and cellular biology, [PMID:14993265]
19. Yun, Jisoo J, Tomida, Akihiro A, Andoh, Toshiwo T and Tsuruo, Takashi T.. (2004) Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.. The Journal of biological chemistry, (23): [PMID:15126503]
20. Malicet, Cédric C and 6 more authors.. (2006) Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.. Biochemical and biophysical research communications, (6): [PMID:16300740]
21. Xiao, Shu S and 11 more authors.. (2006) RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:17050680]
22. Zhang, Fengrui F and 10 more authors.. () Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1.. Biochimica et biophysica acta, [PMID:17123647]
23. Bechtel, Stephanie S and 18 more authors.. (2007) The full-ORF clone resource of the German cDNA Consortium.. BMC genomics, (31): [PMID:17974005]
24. Cooper, Eric M EM and 5 more authors.. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.. The EMBO journal, (18): [PMID:19214193]
25. Wang, Hailong H and 6 more authors.. (2011) Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway.. Cellular and molecular life sciences : CMLS, [PMID:20978819]
26. Granata, Alessandra A, Koo, Seong Joo SJ, Haucke, Volker V, Schiavo, Giampietro G and Warner, Thomas T TT.. (2011) CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.. The EMBO journal, (5): [PMID:21102408]
27. Shi, Y Y and 16 more authors.. (2011) C10ORF97 is a novel tumor-suppressor gene of non-small-cell lung cancer and a functional variant of this gene increases the risk of non-small-cell lung cancer.. Oncogene, (29): [PMID:21499297]
28. Zhou, Jun J and 6 more authors.. (2012) Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.. Biochemical and biophysical research communications, (15): [PMID:22609399]
29. Ebina, Manato M and 5 more authors.. (2013) Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.. PloS one, [PMID:23776465]
30. Rozen, Shelly S and 8 more authors.. (2015) CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.. Cell reports, (20): [PMID:26456823]
31. Li, Jing J and 21 more authors.. (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.. Nature chemical biology, [PMID:28244987]
32. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]

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SKU	Size	Availability	Price
Ab111428-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab111428-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
Ab111428-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$309.90
Ab111428-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,499.90

Recombinant JAB1 Antibody - Primary antibody, specific to JAB1, Rabbit IgG