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Recombinant JNK1 Antibody - Primary antibody, specific to MAPK8, Rabbit IgG

    Application:
  • IF/ICC
  • WB
Features and benefitsView More
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab111518
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab111518-10μl
10μl
2
$66.90
Ab111518-50μl
50μl
1
$199.90
Ab111518-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab111518-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90

Recombinant; Rabbit anti Human JNK1 Antibody; WB; Unconjugated

AI Insight

Basic Description

Product NameRecombinant JNK1 Antibody - Primary antibody, specific to MAPK8, Rabbit IgG
SynonymsAI849689 antibody | c Jun N terminal kinase 1 antibody | C-JUN kinase 1 antibody | c-Jun N-terminal kinase 1 antibody | EC 2.7.11.24 antibody | JNK 1 antibody | JNK antibody | JNK-46 antibody | JNK1A2 antibody | JNK21B1/2 antibody | MAP kinase 8 antibody
Specifications & PurityExactAb™, Validated, Recombinant, 1.0 mg/mL
Host speciesRabbit
SpecificityMAPK8
ImmunogenA synthetic peptide derived from human JNK1 (AA 325-343)
Positive ControlWB: C6, U937, HeLa, MCF7 and Jurkat cell lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human JNK1 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500 - 1/1000
ICC/IF: 1/50-1/200
Protein Function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Post-translational
Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodAntigen affinity purified
FormLiquid
Concentration1.0 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Recombinant JNK1 Antibody (Ab111518) - Western Blot
All lanes: Recombinant JNK1 Antibody (Ab111518) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 48 kDa
Observed band size: 42 kDa
Exposure time: 60.0 s


Associated Targets(Human)

MAPK8 Tchem Mitogen-activated protein kinase 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase, JNK (688 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

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Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Application

ApplicationDilution info
WB1/500-1/1000

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1/500-1/1000

IF/ICC 1/50-1/200

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1/50-1/200

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0102421Certificate of AnalysisJan 15, 2024 Ab111518
ZJ24F0102422Certificate of AnalysisJan 15, 2024 Ab111518

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