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Recombinant JNK1/JNK2/JNK3 Antibody

Recombinant

Validated

ExactAb™

See COA

Application:

IF/ICC
IP
WB

Features and benefits

Host species: Rabbit
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG
Conjugation: Unconjugated

Item Number

Ab111513

Grouped product items
SKU	Size	Availability	Price
Ab111513-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab111513-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$209.90
Ab111513-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$329.90
Ab111513-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,099.90

Recombinant; Rabbit anti Human JNK1/JNK2/JNK3 Antibody; WB, ICC, IF, IP; Unconjugated

View related series

Click to view target information: MAPK8 Click to view target information: MAP3K10 Click to view target information: MAPK9

Accession#:P45983 Accession#:P45984 Accession#:P53779 Gene ID:5599 Gene ID:5601 Gene ID:5602 JNK1 JNK2 JNK3 MAPK10 MAPK8 MAPK9

Basic Description

Product Name	Recombinant JNK1/JNK2/JNK3 Antibody
Synonyms	C Jun kinase 2 antibody \| c Jun N terminal kinase 1 antibody \| c Jun N terminal kinase 2 antibody \| c Jun N terminal kinase 3 antibody \| c-Jun N-terminal kinase 1 antibody \| JNK 46 antibody \| JNK 55 antibody \| JNK antibody \| JNK-46 antibody \| JNK1 antibod
Specifications & Purity	Recombinant, ExactAb™, Validated, See COA
Host species	Rabbit
Specificity	JNK1/JNK2/JNK3
Immunogen	A synthetic peptide derived from human JNK1/JNK2/JNK3 (AA 1-400).
Positive Control	WB: MCF7, Jurkat and K562 cell lysates. IF/ICC: HeLa cells. IP: HeLa lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human JNK1/JNK2/JNK3 Antibody, Recombinant, could be used for WB, ICC, IF, IP and so on. Application: WB: 1/1000-1/2000 ICC/IF: 1/50-1/200 IP: 1/50 Protein Function： Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	See COA
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAPK8 Tchem Mitogen-activated protein kinase 8 (0 Activities)

Discover Target: MAPK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 (0 Activities)

Discover Target: MAP3K10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK9 Tchem Mitogen-activated protein kinase 9 (0 Activities)

Discover Target: MAPK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK9 Tchem c-Jun N-terminal kinase 2 (4655 Activities)

Discover Target: MAPK9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 (401 Activities)

Discover Target: MAP3K10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)

Discover Target: MAPK8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK8 Tchem c-Jun N-terminal kinase, JNK (688 Activities)

Discover Target: MAPK8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Application

Dilution info

IF/ICC

1/50-1/200

1/1000 - 1/2000

1/50

Solution Calculators

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Recombinant JNK1/JNK2/JNK3 Antibody

Basic Description

Product Properties

Associated Targets(Human)

Mechanisms of Action

Application

Certificates

Certificate of Analysis(COA)

Related Documents

FAQs and Articles

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Application	Dilution info
IF/ICC	1/50-1/200 "> 1/50-1/200
WB	1/1000 - 1/2000 "> 1/1000 - 1/2000
IP	1/50