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Recombinant JNK1/JNK2/JNK3 Antibody

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human JNK1/JNK2/JNK3 Antibody; WB, ICC, IF, IP; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • IF/ICC
  • IP
  • WB
Item Number
Ab111513
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab111513-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab111513-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$209.90
Ab111513-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$329.90
Ab111513-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,099.90
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Recombinant; Rabbit anti Human JNK1/JNK2/JNK3 Antibody; WB, ICC, IF, IP; Unconjugated

View related series
Click to view target information: MAPK8 Click to view target information: MAP3K10 Click to view target information: MAPK9
Accession#:P45983 Accession#:P45984 Accession#:P53779 Gene ID:5599 Gene ID:5601 Gene ID:5602 JNK1 JNK2 JNK3 MAPK10 MAPK8 MAPK9

Basic Description

Product NameRecombinant JNK1/JNK2/JNK3 Antibody
SynonymsC Jun kinase 2 antibody | c Jun N terminal kinase 1 antibody | c Jun N terminal kinase 2 antibody | c Jun N terminal kinase 3 antibody | c-Jun N-terminal kinase 1 antibody | JNK 46 antibody | JNK 55 antibody | JNK antibody | JNK-46 antibody | JNK1 antibod
Specifications & PurityExactAb™, Validated, Recombinant, Lot by Lot
Host speciesRabbit
SpecificityJNK1/JNK2/JNK3
ImmunogenA synthetic peptide derived from human JNK1/JNK2/JNK3 (AA 1-400).
Positive Control WB: HeLa, 293, C6, MCF-7, K562, Mouse liver, spleen, heart, lung, brain, Rat liver, spleen, kidney, brain lysates. ICC/IF: HeLa cells. IP: HeLa lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human JNK1/JNK2/JNK3 Antibody, Recombinant, could be used for WB, ICC, IF, IP and so on.
Application:
WB: 1/1000-1/2000
ICC/IF: 1/50-1/200
IP: 1/50
Protein Function：
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MAPK8 Tchem Mitogen-activated protein kinase 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPK9 Tchem Mitogen-activated protein kinase 9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPK9 Tchem c-Jun N-terminal kinase 2 (4655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 (401 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase, JNK (688 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK8 Tchem Mitogen-activated protein kinase 8/9 (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
ICC/IF

1/50-1/200

WB

1/1000 - 1/2000

IP

1/50

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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