Recombinant LEF1 Antibody - Primary antibody, specific to LEF1, Rabbit IgG

    Application:
  • IHC
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
  • Clone Number: MyR1-LEF1
  • Conjugation: Unconjugated
Item Number
Ab112964
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab112964-10μl
10μl
In stock
$49.90
Ab112964-50μl
50μl
In stock
$159.90
Ab112964-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$229.90
Ab112964-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,199.90

Recombinant (MyR1-LEF1); Rabbit anti Human LEF1 Antibody; IHC; Unconjugated

Basic Description

Product NameRecombinant LEF1 Antibody - Primary antibody, specific to LEF1, Rabbit IgG
SynonymsDKFZp586H0919 antibody | FLJ46390 antibody | LEF 1 antibody | LEF-1 antibody | Lef1 antibody | LEF1_HUMAN antibody | Lymphoid enhancer binding factor 1 antibody | Lymphoid enhancer-binding factor 1 antibody | T cell specific transcription factor 1 alpha a
Specifications & PurityExactAb™, Validated, Recombinant, 0.24 mg/mL
Host speciesRabbit
SpecificityLEF1
Positive ControlIHC: Human tonsil tissue.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human LEF1 Antibody, Recombinant (MyR1-LEF1), could be used for IHC and so on.
Application
IHC: 1/100-1/200
Protein Function
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.24 mg/mL
Storage TempStore at 2-8°C,Freeze prohibited
Shipped InWet ice
Stability And StorageStore at 2-8°C long term (36 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant LEF1 Antibody (Ab112964) - IHC
Immunohistochemistry analysis of paraffin-embedded human tonsil tissue labelling LEF1 with Recombinant LEF1 Antibody (Ab112964) at 1/200 dilution. The section was incubated with Ab112964 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.​

Associated Targets(Human)

LEF1 Tchem Lymphoid enhancer-binding factor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Application

ApplicationDilution info
IHC1/100 - 1/200

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1/100 - 1/200

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0505264Certificate of AnalysisMay 09, 2024 Ab112964
ZJ24F0505263Certificate of AnalysisMay 09, 2024 Ab112964

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