| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab113511-10μl | 10μl | In stock | $59.90 | |
| Ab113511-50μl | 50μl | In stock | $179.90 | |
| Ab113511-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $269.90 | |
| Ab113511-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,399.90 |
Recombinant; Rabbit anti Human LRP1 Antibody; WB, IHC, ICC, IF; Unconjugated
| Product Name | Recombinant LRP1 Antibody - Primary antibody, specific to LRP1, Rabbit IgG |
|---|---|
| Synonyms | A2MR antibody | Alpha 2 macroglobulin receptor antibody | alpha 2MR antibody | Alpha-2-macroglobulin receptor antibody | APOER antibody | Apolipoprotein E receptor antibody | APR antibody | CD 91 antibody | CD91 antibody | CD91 antigen antibody | IGFBP3R |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 0.5 mg/mL |
| Host species | Rabbit |
| Specificity | LRP1 |
| Immunogen | A synthetic peptide derived from human LRP1 (AA 4491-4504) |
| Positive Control | WB: Hep G2 and SK-N-SH cell lysates . IHC: Human cholangiocarcinoma tissue. IF/ICC: U87-MG cells. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description |
Rabbit anti Human LRP1 Antibody, Recombinant, could be used for WB, IHC, ICC, IF and so on. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Antigen affinity purified |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant LRP1 Antibody (Ab113511) - Western Blot
All lanes: Recombinant LRP1 Antibody (Ab113511) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 85 kDa
Observed band size: 85 kDa
Exposure time: 1.0 s
Recombinant LRP1 Antibody (Ab113511) - IF/ICC
Immunocytochemistry analysis of LRP1 (green) in U87-MG using Recombinant LRP1 Antibody (Ab113511), and cells were counterstained with DAPI (blue).
Recombinant LRP1 Antibody (Ab113511) - IHC
Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using Recombinant LRP1 Antibody (Ab113511). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| WB | 1/500-1/2000 "> 1/500-1/2000 |
| IHC | 1/50 - 1/100 "> 1/50 - 1/100 |
| IF/ICC | 1/50 - 1/200 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0202945 | Certificate of Analysis | Mar 01, 2024 | Ab113511 |
| ZJ24F0202944 | Certificate of Analysis | Mar 01, 2024 | Ab113511 |
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| 2. Kristensen, T T and 5 more authors.. (1990) Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.. FEBS letters, (10): [PMID:1702392] |
| 3. Herz, J J, Kowal, R C RC, Goldstein, J L JL and Brown, M S MS.. (1990) Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.. The EMBO journal, [PMID:2112085] |
| 4. Kütt, H H, Herz, J J and Stanley, K K KK.. (1989) Structure of the low-density lipoprotein receptor-related protein (LRP) promoter.. Biochimica et biophysica acta, (22): [PMID:2597675] |
| 5. Herz, J J and 5 more authors.. (1988) Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.. The EMBO journal, (20): [PMID:3266596] |
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| 8. Van Leuven, F F, Stas, L L, Thiry, E E, Nelissen, B B and Miyake, Y Y.. (1998) Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms.. Genomics, (1): [PMID:9782078] |
| 9. Huang, W W, Dolmer, K K and Gettins, P G PG.. (1999) NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.. The Journal of biological chemistry, (14): [PMID:10318830] |
| 10. Dolmer, K K, Huang, W W and Gettins, P G PG.. (2000) NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.. The Journal of biological chemistry, (4): [PMID:10652313] |
| 11. Muramatsu, H H and 5 more authors.. (2000) LDL receptor-related protein as a component of the midkine receptor.. Biochemical and biophysical research communications, (21): [PMID:10772929] |
| 12. Su, Hua Poo HP and 6 more authors.. (2002) Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).. The Journal of biological chemistry, (5): [PMID:11729193] |
| 13. Loukinova, Elena E and 9 more authors.. (2002) Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.. The Journal of biological chemistry, (3): [PMID:11854294] |
| 14. Rohlena, Jakub J, Kolkman, Joost A JA, Boertjes, Ria C RC, Mertens, Koen K and Lenting, Peter J PJ.. (2003) Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein.. The Journal of biological chemistry, (14): [PMID:12522212] |
| 15. May, Petra P and Herz, Joachim J.. (2003) LDL receptor-related proteins in neurodevelopment.. Traffic (Copenhagen, Denmark), [PMID:12713657] |
| 16. Kinoshita, Ayae A, Shah, Tejal T, Tangredi, Michelle M MM, Strickland, Dudley K DK and Hyman, Bradley T BT.. (2003) The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.. The Journal of biological chemistry, (17): [PMID:12888553] |
| 17. Zhu, Yanjuan Y and 10 more authors.. (2004) LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration.. Circulation research, (2): [PMID:14764453] |
| 18. Ranganathan, Sripriya S and 7 more authors.. (2004) Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.. The Journal of biological chemistry, (24): [PMID:15272003] |
| 19. Knauth, Peter P and 7 more authors.. (2005) Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.. Journal of molecular biology, (8): [PMID:15769472] |
| 20. Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952] |
| 21. Scherer, Steven E SE and 216 more authors.. (2006) The finished DNA sequence of human chromosome 12.. Nature, (16): [PMID:16541075] |
| 22. Jensen, Gitte A GA and 8 more authors.. (2006) Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.. Journal of molecular biology, (29): [PMID:16938309] |
| 23. Sjöblom, Tobias T and 28 more authors.. (2006) The consensus coding sequences of human breast and colorectal cancers.. Science (New York, N.Y.), (13): [PMID:16959974] |
| 24. Caratù, Ginevra G and 8 more authors.. (2007) Identification of the ligands of protein interaction domains through a functional approach.. Molecular & cellular proteomics : MCP, [PMID:17124247] |
| 25. Franchini, Massimo M and Montagnana, Martina M.. (2011) Low-density lipoprotein receptor-related protein 1: new functions for an old molecule.. Clinical chemistry and laboratory medicine, [PMID:21391865] |
| 26. de Ligt, Joep J and 16 more authors.. (2012) Diagnostic exome sequencing in persons with severe intellectual disability.. The New England journal of medicine, (15): [PMID:23033978] |
| 27. Klar, Joakim J and 8 more authors.. (2015) Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans.. Journal of medical genetics, [PMID:26142438] |
| 28. Rauch, Jennifer N and 12 more authors.. (2020) LRP1 is a master regulator of tau uptake and spread.. Nature, [PMID:32296178] |
| 29. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460] |
