Recombinant MUC2 Antibody - Primary antibody, specific to MUC2, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human MUC2 Antibody; WB; Unconjugated

  • Species reactivity(Reacts with): Human,Rat
  • Isotype: Rabbit IgG
    Application:
  • WB
Item Number
Ab116430
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab116430-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab116430-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
Ab116430-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab116430-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90

Recombinant; Rabbit anti Human MUC2 Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant MUC2 Antibody - Primary antibody, specific to MUC2, Rabbit IgG
SynonymsIntestinal mucin 2 antibody | Intestinal mucin-2 antibody | MLP antibody | MUC 2 antibody | MUC-2 antibody | Muc2 antibody | MUC2_HUMAN antibody | Mucin 2 antibody | Mucin 2 intestinal antibody | Mucin 2 intestinal/tracheal antibody | Mucin 2 oligomeric m
Specifications & PurityExactAb™, Validated, Recombinant, 0.4 mg/mL
Host speciesRabbit
SpecificityMUC2
ImmunogenA synthetic peptide derived from human MUC2 (AA 5000-5100).
Positive ControlWB: SH-SY5Y lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human MUC2 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500 – 1/1000
Protein Function
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.4 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MUC2 Tdark Mucin-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

References

1. Todd D Taylor,Hideki Noguchi,Yasushi Totoki,Atsushi Toyoda,Yoko Kuroki,Ken Dewar,Christine Lloyd,Takehiko Itoh,Tadayuki Takeda,Dae-Won Kim,Xinwei She,Karen F Barlow,Toby Bloom,Elspeth Bruford,Jean L Chang,Christina A Cuomo,Evan Eichler,Michael G FitzGerald,David B Jaffe,Kurt LaButti,Robert Nicol,Hong-Seog Park,Christopher Seaman,Carrie Sougnez,Xiaoping Yang,Andrew R Zimmer,Michael C Zody,Bruce W Birren,Chad Nusbaum,Asao Fujiyama,Masahira Hattori,Jane Rogers,Eric S Lander,Yoshiyuki Sakaki.  (2006-03-24)  Human chromosome 11 DNA sequence and analysis including novel gene identification..  Nature,  440  ((7083)): (497-500).  [PMID:16554811]
2. Gum, J R JR and 5 more authors..  (1992)  The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region..  The Journal of biological chemistry,    (25):   [PMID:1400449]
3. Xu, G G and 8 more authors..  (1992)  Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5..  Biochemical and biophysical research communications,    (16):   [PMID:1550588]
4. Toribara, N W NW and 6 more authors..  (1991)  MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism..  The Journal of clinical investigation,      [PMID:1885763]
5. Gum, J R JR and 5 more authors..  (1989)  Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism..  The Journal of biological chemistry,    (15):   [PMID:2703501]
6. Gum, J R JR, Hicks, J W JW, Toribara, N W NW, Siddiki, B B and Kim, Y S YS..  (1994)  Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor..  The Journal of biological chemistry,    (28):   [PMID:8300571]
7. Silverman, H S HS and 10 more authors..  (2001)  In vivo glycosylation of mucin tandem repeats..  Glycobiology,      [PMID:11445551]
8. Lidell, Martin E ME, Johansson, Malin E V ME and Hansson, Gunnar C GC..  (2003)  An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway..  The Journal of biological chemistry,    (18):   [PMID:12582180]
9. Ishinaga, Hajime H and 5 more authors..  (2005)  Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells..  Pharmacology,      [PMID:15475658]
10. Moehle, Christoph C and 9 more authors..  (2006)  Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease..  Journal of molecular medicine (Berlin, Germany),      [PMID:17058067]
11. Park, Sung-Woo SW and 7 more authors..  (2009)  The protein disulfide isomerase AGR2 is essential for production of intestinal mucus..  Proceedings of the National Academy of Sciences of the United States of America,    (28):   [PMID:19359471]
12. Johansson, Malin E V ME, Thomsson, Kristina A KA and Hansson, Gunnar C GC..  (2009)  Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein..  Journal of proteome research,      [PMID:19432394]
13. Javitt, Gabriel and 6 more authors..  (2019)  Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains..  Journal of molecular biology,    (6):   [PMID:31310764]

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