Recombinant MUC4 Antibody - Primary antibody, specific to MUC4, Rabbit IgG

    Application:
  • WB
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab116451
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab116451-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab116451-50μl
50μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$199.90
Ab116451-100μl
100μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$299.90
Ab116451-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90

Recombinant; Rabbit anti Human MUC4 Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant MUC4 Antibody - Primary antibody, specific to MUC4, Rabbit IgG
SynonymsAscites sialoglycoprotein 1 antibody | Ascites sialoglycoprotein 2 antibody | Ascites sialoglycoprotein antibody | ASGP antibody | ASGP-1 antibody | ASGP-2 antibody | HSA276359 antibody | MUC 4 antibody | MUC-4 antibody | Muc4 antibody | MUC4_HUMAN antibo
Specifications & PurityExactAb™, Validated, Recombinant, 0.65 mg/mL
Host speciesRabbit
SpecificityMUC4
ImmunogenA synthetic peptide derived from human MUC4 (AA 1564-1673).
Positive ControlWB: MCF-7, A549 and HeLa cell lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human MUC4 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500 – 1/1000
Protein Function
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.65 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant MUC4 Antibody (Ab116451) - Western Blot
All lanes: Recombinant MUC4 Antibody (Ab116451) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 120 kDa
Observed band size: 118 kDa
Exposure time: 23.9 s

Associated Targets(Human)

SPEN Tbio Msx2-interacting protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MUC4 Tbio Mucin-4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/1000

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F1001215Certificate of AnalysisOct 10, 2023 Ab116451
ZJ23F1001214Certificate of AnalysisOct 10, 2023 Ab116451

Related Documents

References

1. Porchet, N N and 9 more authors..  (1991)  Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs..  Biochemical and biophysical research communications,    (15):   [PMID:1673336]
2. Nollet, S S and 7 more authors..  (1998)  Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat array..  The Biochemical journal,    (15):   [PMID:9620877]
3. Moniaux, N N and 5 more authors..  (1999)  Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin..  The Biochemical journal,    (1):   [PMID:10024507]
4. Moniaux, N N and 5 more authors..  (2000)  Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins..  European journal of biochemistry,      [PMID:10880978]
5. Choudhury, A A and 5 more authors..  (2000)  Human MUC4 mucin cDNA and its variants in pancreatic carcinoma..  Journal of biochemistry,      [PMID:10920259]
6. Desseyn, Jean-Luc JL, Clavereau, Isabelle I and Laine, Anne A..  (2002)  Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4..  European journal of biochemistry,      [PMID:12084055]
7. Carraway, Kermit L KL and 9 more authors..  (2002)  Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive..  Progress in nucleic acid research and molecular biology,      [PMID:12102554]
8. Escande, Fabienne F and 5 more authors..  (2002)  Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants..  European journal of biochemistry,      [PMID:12153560]
9. Saitou, M M and 11 more authors..  (2005)  MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas..  Journal of clinical pathology,      [PMID:16049287]
10. Muzny, Donna M DM and 113 more authors..  (2006)  The DNA sequence, annotation and analysis of human chromosome 3..  Nature,    (27):   [PMID:16641997]
11. Karg, Aydanur A, Dinç, Zekiye Aydoğdu ZA, Başok, Oktay O and Uçvet, Ahmet A..  (2006)  MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC)..  Pathology, research and practice,      [PMID:16814944]
12. Zhang, Jin J, Yasin, Mohammad M, Carraway, Coralie A Carothers CA and Carraway, Kermit L KL..  (2006)  MUC4 expression and localization in gastrointestinal tract and skin of human embryos..  Tissue & cell,      [PMID:16914178]

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