Rabbit anti Human Noxa Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Product Properties
Isotype
Rabbit IgG
SDS-PAGE
150 kDa
Purification Method
Antigen affinity purified
Form
Liquid
Concentration
2.0 mg/mL
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Associated Targets(Human)
CEP295NLTdarkCEP295 N-terminal-like protein (0 Activities)
1.Hijikata, M M, Kato, N N, Sato, T T, Kagami, Y Y and Shimotohno, K K.. (1990) Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line.. Journal of virology, [PMID:2398525]
2.Oda, E E and 8 more authors.. (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.. Science (New York, N.Y.), (12):[PMID:10807576]
3.Chen, Lin L and 9 more authors.. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.. Molecular cell, (4):[PMID:15694340]
4.Sun, Yaping Y and Leaman, Douglas W DW.. (2005) Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.. The Journal of biological chemistry, (22):[PMID:15705586]
5.Nusbaum, Chad C and 54 more authors.. (2005) DNA sequence and analysis of human chromosome 18.. Nature, (22):[PMID:16177791]
6.van de Kooij, B B and 8 more authors.. (2013) Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.. Oncogene, (28):[PMID:23563182]
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