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Recombinant NT-proBNP Antibody - Primary antibody, for ELISA,CLIA,LF,GICA,Capture antibody,FIA various applications, from Human, generated in Goat, specific to NT-proBNP, IgG1

Lot by Lot

Application:

Capture Antibody
CLIA
ELISA
FIA
GICA
LF

Features and benefits

Host species: Goat
Species reactivity(Reacts with): Human
Isotype: Goat IgG
Clone Number: 1B8
Conjugation: Unconjugated

Item Number

Ab008412

Grouped product items
SKU	Size	Availability	Price
Ab008412-10μg	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$26.90
Ab008412-50μg	50μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90
Ab008412-100μg	100μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$105.90
Ab008412-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$774.90

Recombinant (1B8); Goat anti Human NT-proBNP antibody; Capture antibody, ELISA, CLIA, LF, GICA, FIA; Unconjugated

View related series

Click to view target information: NPPB

Accession#:P16860 Gene ID:4879 NPPB NT-proBNP

Basic Description

Product Name	Recombinant NT-proBNP Antibody - Primary antibody, for ELISA,CLIA,LF,GICA,Capture antibody,FIA various applications, from Human, generated in Goat, specific to NT-proBNP, IgG1
Synonyms	Brain natriuretic factor prohormone \| Gamma-brain natriuretic peptide \| Iso-ANP \| preproBNP \| proBNP
Specifications & Purity	ExactAb™, Validated, Carrier Free, Azide Free, Recombinant, Lot by Lot
Host Species	Goat
Host species	Goat
Specificity	NT-proBNP
Application	ELISA,CLIA,LF,GICA,Capture antibody,FIA
Immunogen	E. coli-derived recombinant human NT-proBNP (His27-His134)
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Product Description	Application: Capture antibody CLIA: 10-40μg/mg Beads ELISA: 1μg/mL LF/GICA : 1mg/mL Protein function Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	IgG1
SDS-PAGE	150kDa
Purification Method	Protein A purified
Matched Pairs	[Ab007709] NT-proBNP Mouse mAb
Source	CHO supernatant
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -20±5℃ for three years. Avoid freeze/thaw.

Images

Recombinant NT-proBNP Antibody (Ab008412) - Binding ELISA
The binding activity of recombinant NT-proBNP Antibody with NT-proBNP antigen.

NT-proBNP Standard Curve with Antibody Pair (Ab008412 & Ab007709) in CLIA

· Capture antibody: Recombinant NT-proBNP Antibody (Ab008412) at 1.0 μg/mL.

· Detection antibody: NT-proBNP Mouse mAb (Ab007709) at 1.0 μg/mL.

· Linear Range: 5-35000 pg/mL, R ≥ 0.99.

NT-proBNP Standard Curve with Antibody Pair (Ab008412 & Ab007709) in FLFIA

· Capture antibody: Recombinant NT-proBNP Antibody (Ab008412) at 1.0 mg/mL.

· Detection antibody: NT-proBNP Mouse mAb (Ab007709) at 1.0 mg/mL.

· Linear Range: 0-35000 pg/mL, LLOD: 50 pg/mL.

Application

Dilution info

LF/GICA

1 mg/mL

ELISA

1 μg/mL

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0700543	Certificate of Analysis	Jul 06, 2023	Ab008412
ZJ23F0700542	Certificate of Analysis	Jul 06, 2023	Ab008412

References

1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P et al.. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res, 14 (10B): (2121-7). [PMID:15489334] [10.1021/op500134e]
2. Koller, K J KJ and 6 more authors.. (1991) Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).. Science (New York, N.Y.), (5): [PMID:1672777]
3. Kambayashi, Y Y and 8 more authors.. (1990) Isolation and sequence determination of human brain natriuretic peptide in human atrium.. FEBS letters, (1): [PMID:2136732]
4. Hino, J J, Tateyama, H H, Minamino, N N, Kangawa, K K and Matsuo, H H.. (1990) Isolation and identification of human brain natriuretic peptides in cardiac atrium.. Biochemical and biophysical research communications, (16): [PMID:2138890]
5. Sudoh, T T and 5 more authors.. (1989) Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide.. Biochemical and biophysical research communications, (31): [PMID:2522777]
6. Seilhamer, J J JJ and 6 more authors.. (1989) Human and canine gene homologs of porcine brain natriuretic peptide.. Biochemical and biophysical research communications, (15): [PMID:2597152]
7. Jensen, K T KT, Carstens, J J and Pedersen, E B EB.. (1998) Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans.. The American journal of physiology, [PMID:9458824]
8. Yan, W W, Wu, F F, Morser, J J and Wu, Q Q.. (2000) Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:10880574]
9. Ohta, Y Y and 12 more authors.. (2000) Carvedilol enhances atrial and brain natriuretic peptide mRNA expression and release in rat heart.. Journal of cardiovascular pharmacology, [PMID:11206715]
10. Richards, A M AM and 9 more authors.. (2001) Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: prognostic utility and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. Australia-New Zealand Heart Failure Group.. Journal of the American College of Cardiology, (1): [PMID:11401111]
11. Frantz, Robert P RP and 11 more authors.. (2005) Carvedilol therapy is associated with a sustained decline in brain natriuretic peptide levels in patients with congestive heart failure.. American heart journal, [PMID:15864245]
12. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414]
13. He, Xiao-lin XL, Dukkipati, Abhiram A and Garcia, K Christopher KC.. (2006) Structural determinants of natriuretic peptide receptor specificity and degeneracy.. Journal of molecular biology, (25): [PMID:16870210]
14. Lam, Carolyn S P CS, Burnett, John C JC, Costello-Boerrigter, Lisa L, Rodeheffer, Richard J RJ and Redfield, Margaret M MM.. (2007) Alternate circulating pro-B-type natriuretic peptide and B-type natriuretic peptide forms in the general population.. Journal of the American College of Cardiology, (20): [PMID:17367664]
15. Ralat, Luis A LA and 6 more authors.. (2011) Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.. The Journal of biological chemistry, (11): [PMID:21098034]
16. Keane, Fiona M FM, Nadvi, Naveed A NA, Yao, Tsun-Wen TW and Gorrell, Mark D MD.. (2011) Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α.. The FEBS journal, [PMID:21314817]
17. Peng, Jianhao J and 5 more authors.. (2011) Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes.. Biochemical and biophysical research communications, (5): [PMID:21763278]
18. Huntley, Brenda K and 5 more authors.. (2015) Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure.. Circulation. Heart failure, [PMID:25339504]

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