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Recombinant NUMB Antibody - Primary antibody, for WB,IHC various applications, from Human, generated in Rabbit, specific to Human NUMB, Rabbit IgG

Recombinant

Validated

ExactAb™

0.5 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human NUMB Antibody; WB, IHC; Unconjugated
Application: WB,IHC
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab119000

Grouped product items
SKU	Size	Availability	Price
Ab119000-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab119000-50μl	50μl	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$207.90
Ab119000-100μl	100μl	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$297.90
Ab119000-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,007.90

Recombinant; Rabbit anti Human NUMB Antibody; WB, IHC; Unconjugated

View related series

Click to view target information: NUMB

Accession#:P49757 Gene ID:8650 NUMB

Basic Description

Product Name	Recombinant NUMB Antibody - Primary antibody, for WB,IHC various applications, from Human, generated in Rabbit, specific to Human NUMB, Rabbit IgG
Synonyms	C14_5527 antibody; C14orf41 antibody; FLJ31314 antibody; H Numb antibody; H-Numb antibody; Numb antibody;Numb homolog (Drosophila) antibody; Numb homolog antibody; Numb protein homolog antibody; NUMB_HUMAN antibody; Protein numb homolog antibody; Protein
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.5 mg/mL
Host Species	Rabbit
Host species	Rabbit
Specificity	Human NUMB
Application	WB,IHC
Immunogen	Recombinant protein of human NUMB (AA 413-651).
Positive Control	WB: MCF7, A549, HeLa, C6, NIH/3T3; IHC: Human lung cancer
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human NUMB Antibody, Recombinant, could be used for WB and IHC. Application： WB: 1/500-1/1000 IHC: 1/50-1/100 Protein Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Antigen affinity purified
Source	Cell supernatant
Form	Liquid
Concentration	0.5 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Application

Dilution info

IHC

1/50 - 1/100

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F0700727	Certificate of Analysis	Jul 31, 2023	Ab119000
ZJ23F0700726	Certificate of Analysis	Jul 31, 2023	Ab119000

References

1. Sherrington, R R and 32 more authors.. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.. Nature, (29): [PMID:7596406]
2. Salcini, A E AE and 8 more authors.. (1997) Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.. Genes & development, (1): [PMID:9303539]
3. Verdi, J M JM and 6 more authors.. (1999) Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:10468633]
4. Susini, L L and 11 more authors.. (2001) Siah-1 binds and regulates the function of Numb.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:11752454]
5. Heilig, Roland R and 98 more authors.. (2003) The DNA sequence and analysis of human chromosome 14.. Nature, (6): [PMID:12508121]
6. Rossé, Carine C, L'Hoste, Sébastien S, Offner, Nicolas N, Picard, André A and Camonis, Jacques J.. (2003) RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.. The Journal of biological chemistry, (15): [PMID:12775724]
7. Qin, Hanjuan H and 5 more authors.. (2004) A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.. The Journal of biological chemistry, (19): [PMID:14670962]
8. Beausoleil, Sean A SA, Villén, Judit J, Gerber, Scott A SA, Rush, John J and Gygi, Steven P SP.. (2006) A probability-based approach for high-throughput protein phosphorylation analysis and site localization.. Nature biotechnology, [PMID:16964243]
9. Sorensen, Erika B EB and Conner, Sean D SD.. (2008) AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis.. Traffic (Copenhagen, Denmark), [PMID:18657069]
10. Mayya, Viveka V and 7 more authors.. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.. Science signaling, (18): [PMID:19690332]
11. Rigbolt, Kristoffer T G KT and 9 more authors.. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.. Science signaling, (15): [PMID:21406692]
12. Haider, M M, Qiu, Q Q, Bani-Yaghoub, M M, Tsang, B K BK and Gruslin, A A.. (2011) Characterization and role of NUMB in the human extravillous trophopblast.. Placenta, [PMID:21486681]
13. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): [PMID:23186163]

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