Recombinant NUMB Antibody - Primary antibody, for WB,IHC various applications, from Human, generated in Rabbit, specific to Human NUMB, Rabbit IgG

    Application:
  • IHC
  • WB
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab119000
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab119000-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab119000-50μl
50μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$207.90
Ab119000-100μl
100μl
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$297.90
Ab119000-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,007.90

Recombinant; Rabbit anti Human NUMB Antibody; WB, IHC; Unconjugated

Basic Description

Product NameRecombinant NUMB Antibody - Primary antibody, for WB,IHC various applications, from Human, generated in Rabbit, specific to Human NUMB, Rabbit IgG
SynonymsC14_5527 antibody | C14orf41 antibody | FLJ31314 antibody | H Numb antibody | H-Numb antibody | Numb antibody | Numb homolog (Drosophila) antibody | Numb homolog antibody | Numb protein homolog antibody | NUMB_HUMAN antibody | Protein numb homolog antibod
Specifications & PurityExactAb™, Validated, Recombinant, 0.5 mg/mL
Host SpeciesRabbit
Host speciesRabbit
SpecificityHuman NUMB
ApplicationWB,IHC
ImmunogenRecombinant protein of human NUMB (AA 413-651).
Positive ControlWB: MCF7, A549, HeLa, C6, NIH/3T3; IHC: Human lung cancer
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human NUMB Antibody, Recombinant, could be used for WB and IHC.
Application:
WB: 1/500-1/1000
IHC: 1/50-1/100
Protein Function
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodAntigen affinity purified
SourceCell supernatant
FormLiquid
Concentration0.5 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

NUMB Tbio Protein numb homolog (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
IHC1/50 - 1/100

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1/50 - 1/100

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0700727Certificate of AnalysisJul 31, 2023 Ab119000
ZJ23F0700726Certificate of AnalysisJul 31, 2023 Ab119000

Related Documents

References

1. Sherrington, R R and 32 more authors..  (1995)  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease..  Nature,    (29):   [PMID:7596406]
2. Salcini, A E AE and 8 more authors..  (1997)  Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module..  Genes & development,    (1):   [PMID:9303539]
3. Verdi, J M JM and 6 more authors..  (1999)  Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage..  Proceedings of the National Academy of Sciences of the United States of America,    (31):   [PMID:10468633]
4. Susini, L L and 11 more authors..  (2001)  Siah-1 binds and regulates the function of Numb..  Proceedings of the National Academy of Sciences of the United States of America,    (18):   [PMID:11752454]
5. Heilig, Roland R and 98 more authors..  (2003)  The DNA sequence and analysis of human chromosome 14..  Nature,    (6):   [PMID:12508121]
6. Rossé, Carine C, L'Hoste, Sébastien S, Offner, Nicolas N, Picard, André A and Camonis, Jacques J..  (2003)  RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis..  The Journal of biological chemistry,    (15):   [PMID:12775724]
7. Qin, Hanjuan H and 5 more authors..  (2004)  A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division..  The Journal of biological chemistry,    (19):   [PMID:14670962]
8. Beausoleil, Sean A SA, Villén, Judit J, Gerber, Scott A SA, Rush, John J and Gygi, Steven P SP..  (2006)  A probability-based approach for high-throughput protein phosphorylation analysis and site localization..  Nature biotechnology,      [PMID:16964243]
9. Sorensen, Erika B EB and Conner, Sean D SD..  (2008)  AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis..  Traffic (Copenhagen, Denmark),      [PMID:18657069]
10. Mayya, Viveka V and 7 more authors..  (2009)  Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions..  Science signaling,    (18):   [PMID:19690332]
11. Rigbolt, Kristoffer T G KT and 9 more authors..  (2011)  System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation..  Science signaling,    (15):   [PMID:21406692]
12. Haider, M M, Qiu, Q Q, Bani-Yaghoub, M M, Tsang, B K BK and Gruslin, A A..  (2011)  Characterization and role of NUMB in the human extravillous trophopblast..  Placenta,      [PMID:21486681]
13. Zhou, Houjiang H and 6 more authors..  (2013)  Toward a comprehensive characterization of a human cancer cell phosphoproteome..  Journal of proteome research,    (4):   [PMID:23186163]

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