Rabbit anti Human p40 - DeltaNp63 Antibody, Recombinant (MyR1-P40), could be used for IHC and so on. Application IHC: 1/100-1/200 Relevance Differentiating between lung adenocarcinoma and squamous cell carcinoma is an important distinction with therapeutic implications. Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types, particularly lymphomas. p40 is a relatively unknown marker that recognizes ?Np63-a p63 isoform suggested to be highly specific for squamous/basal cells. p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.
Product Properties
Isotype
Rabbit IgG
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
0.03 mg/mL
Storage Temp
Store at 2-8°C,Freeze prohibited
Shipped In
Wet ice
Stability And Storage
Store at 2-8°C long term (36 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant p40 - DeltaNp63 Antibody (Ab119740) - IHC Immunohistochemistry analysis of paraffin-embedded human tonsil tissue labelling p40 - DeltaNp63 with Recombinant p40 - DeltaNp63 Antibody (Ab119740) at 1/200 dilution. The section was incubated with Ab119740 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.