Recombinant PER2 Antibody - Primary antibody, specific to PER2, Rabbit IgG
Synonyms
FASPS; FASPS1; Circadian clock protein PERIOD 2 antibody; FASPS antibody; FASPS1 antibody; hPER 2 antibody; hPER2 antibody; KIAA0347 antibody; OTTHUMP00000164476 antibody; PER 2 antibody; PER2 antibody; PER2_HUMAN antibody; Period 2 antibody; Period 2 iso
Specifications & Purity
ExactAb™, Validated, Recombinant, 0.6 mg/mL
Host species
Rabbit
Specificity
PER2
Immunogen
A synthetic peptide derived from human PER2 (AA 50-100)
Positive Control
WB: A549 and Hep G2 cell lysates.
Conjugation
Unconjugated
Grade
ExactAb™, Recombinant, Validated
Product Description
Rabbit anti Human PER2 Antibody, Recombinant, could be used for WB and so on. Application WB: 1/500-1/1000 Protein Function Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation.
Product Properties
Isotype
Rabbit IgG
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
0.6 mg/mL
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant PER2 Antibody (Ab121233) - Western Blot All lanes: Recombinant PER2 Antibody (Ab121233) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 137 kDa Observed band size: 130 kDa Exposure time: 10.0 s
Associated Targets(Human)
PER2TchemPeriod circadian protein homolog 2 (0 Activities)
1.Nagase, T T and 9 more authors.. (1997) Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA research : an international journal for rapid publication of reports on genes and genomes, (28):[PMID:9205841]
2.Shearman, L P LP, Zylka, M J MJ, Weaver, D R DR, Kolakowski, L F LF and Reppert, S M SM.. (1997) Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.. Neuron, [PMID:9427249]
3.Camacho, F F and 9 more authors.. (2001) Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.. FEBS letters, (2):[PMID:11165242]
4.Toh, K L KL and 7 more authors.. (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.. Science (New York, N.Y.), (9):[PMID:11232563]
5.Miyazaki, Koyomi K and 5 more authors.. (2004) Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts.. The Biochemical journal, (15):[PMID:14750904]
6.Hillier, Ladeana W LW and 121 more authors.. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature, (7):[PMID:15815621]
7.Sjöblom, Tobias T and 28 more authors.. (2006) The consensus coding sequences of human breast and colorectal cancers.. Science (New York, N.Y.), (13):[PMID:16959974]
8.Miki, Takao T and 8 more authors.. (2012) PML regulates PER2 nuclear localization and circadian function.. The EMBO journal, (21):[PMID:22274616]
9.Partch, Carrie L; Green, Carla B and Takahashi, Joseph S.. (2014) Molecular architecture of the mammalian circadian clock.. Trends in cell biology, [PMID:23916625]
10.Avitabile, Daniele D and 6 more authors.. (2014) Nucleolar localization and circadian regulation of Per2S, a novel splicing variant of the Period 2 gene.. Cellular and molecular life sciences : CMLS, [PMID:24202686]
11.Qu, Meng M, Duffy, Tomas T, Hirota, Tsuyoshi T and Kay, Steve A SA.. (2018) Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.. Proceedings of the National Academy of Sciences of the United States of America, (26):[PMID:30530698]
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