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Recombinant PEX19 Antibody - Primary antibody, specific to PEX19, Rabbit IgG

ExactAb™
Recombinant
Validated
0.4 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human PEX19 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab121373

Grouped product items
SKU	Size	Availability	Price
Ab121373-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab121373-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
Ab121373-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$309.90
Ab121373-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,899.90

Recombinant; Rabbit anti Human PEX19 Antibody; WB; Unconjugated

View related series

Accession#:P40855 Gene ID:5824 PEX19

Basic Description

Product Name	Recombinant PEX19 Antibody - Primary antibody, specific to PEX19, Rabbit IgG
Synonyms	D1S2223E \| HK33 \| PBD12A \| PMP1 \| PMPI \| PXF \| PXMP1 \| 33 kDa housekeeping protein antibody \| D1S2223E antibody \| HK33 antibody \| Housekeeping gene 33kD antibody \| OK/SW-cl.22 antibody \| PBD12A antibody \| Peroxin 19 antibody \| Peroxin-19 antibody \| Peroxi
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.4 mg/mL
Host species	Rabbit
Specificity	PEX19
Immunogen	A synthetic peptide derived from human PEX19 (AA 30-89)
Positive Control	WB: Mouse brain, Jurkat lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human PEX19 Antibody, Recombinant, could be used for WB and so on. Application WB: 1/500-1/1000 Protein Function Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.4 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant PEX19 Antibody (Ab121373) - Western Blot
All lanes: Recombinant PEX19 Antibody (Ab121373) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 33 kDa
Observed band size: 40 kDa
Exposure time: 98.2 s

Application

Dilution info

1/500-1/1000

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0607261	Certificate of Analysis	Jun 24, 2024	Ab121373
ZJ24F0607260	Certificate of Analysis	Jun 24, 2024	Ab121373

References

1. Braun, A A, Kammerer, S S, Weissenhorn, W W, Weiss, E H EH and Cleve, H H.. (1994) Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1.. Gene, (2): [PMID:8076834]
2. Kammerer, S S and 7 more authors.. (1997) Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.. Genomics, (1): [PMID:9339377]
3. Matsuzono, Y Y and 9 more authors.. (1999) Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:10051604]
4. Sacksteder, K A KA and 5 more authors.. (2000) PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.. The Journal of cell biology, (6): [PMID:10704444]
5. Gloeckner, C J CJ and 8 more authors.. (2000) Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.. Biochemical and biophysical research communications, (29): [PMID:10777694]
6. Sugihara, T T and 5 more authors.. (2001) Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.. The Journal of biological chemistry, (1): [PMID:11259404]
7. Fransen, M M, Wylin, T T, Brees, C C, Mannaerts, G P GP and Van Veldhoven, P P PP.. (2001) Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.. Molecular and cellular biology, [PMID:11390669]
8. Mayerhofer, Peter U PU, Kattenfeld, Tanja T, Roscher, Adelbert A AA and Muntau, Ania C AC.. (2002) Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.. Biochemical and biophysical research communications, (15): [PMID:11883941]
9. Jones, Jacob M JM, Morrell, James C JC and Gould, Stephen J SJ.. (2004) PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.. The Journal of cell biology, (5): [PMID:14709540]
10. Fang, Yi Y, Morrell, James C JC, Jones, Jacob M JM and Gould, Stephen J SJ.. (2004) PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.. The Journal of cell biology, (15): [PMID:15007061]
11. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414]
12. Neufeld, Christian C and 11 more authors.. (2009) Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.. The EMBO journal, (18): [PMID:19197237]
13. Schmidt, Friederike F and 7 more authors.. (2010) Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.. The Journal of biological chemistry, (13): [PMID:20554521]
14. Mohamed, Sarar S and 5 more authors.. (2010) A mutation in PEX19 causes a severe clinical phenotype in a patient with peroxisomal biogenesis disorder.. American journal of medical genetics. Part A, [PMID:20683989]
15. Sato, Yasuhiko Y and 6 more authors.. (2010) Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.. The EMBO journal, (15): [PMID:21102411]
16. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378]
17. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): [PMID:23186163]
18. Yang, Xinping X and 37 more authors.. (2016) Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.. Cell, (11): [PMID:26871637]

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