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Recombinant Pumilio 2 Antibody - Primary antibody, specific to Pumilio 2, Rabbit IgG

Recombinant

Validated

ExactAb™

0.55 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human Pumilio 2 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab123958

Grouped product items
SKU	Size	Availability	Price
Ab123958-10μl	10μl	In stock	$69.90
Ab123958-50μl	50μl	In stock	$189.90
Ab123958-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$289.90
Ab123958-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,599.90

Recombinant; Rabbit anti Human Pumilio 2 Antibody; WB; Unconjugated

View related series

Click to view target information: PUM2

Accession#:Q8TB72 Gene ID:23369 PUM2 Pumilio 2

Basic Description

Product Name	Recombinant Pumilio 2 Antibody - Primary antibody, specific to Pumilio 2, Rabbit IgG
Synonyms	FLJ36528 antibody \| KIAA0235 antibody \| MGC138251 antibody \| MGC138253 antibody \| PUM 2 antibody \| PUM2 antibody \| PUM2_HUMAN antibody \| PUMH 2 antibody \| PUMH2 antibody \| Pumilio (Drosphila) homolog 2 antibody \| Pumilio homolog 2 (Drosophila)antibody \| P
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.55 mg/mL
Host species	Rabbit
Specificity	Pumilio 2
Immunogen	A synthetic peptide derived from human Pumilio 2 (AA 2-46)
Positive Control	WB: 293T lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human Pumilio 2 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.55 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Application

Dilution info

1/500-1/1000

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505554	Certificate of Analysis	May 14, 2024	Ab123958
ZJ24F0505555	Certificate of Analysis	May 14, 2024	Ab123958

References

1. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N. (1996) Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.. DNA Res, 3 (5): (321-9, 341-54). [PMID:9039502]
2. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed. (2009-05-06) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.. Analytical chemistry, 81 ((11)): (4493-4501). [PMID:19413330]
3. Nakajima, Daisuke D and 5 more authors.. (2002) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.. DNA research : an international journal for rapid publication of reports on genes and genomes, (30): [PMID:12168954]
4. Spassov, Danislav S DS and Jurecic, Roland R.. (2002) Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.. Gene, (16): [PMID:12459267]
5. Moore, Frederick L FL and 7 more authors.. (2003) Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.. Proceedings of the National Academy of Sciences of the United States of America, (21): [PMID:12511597]
6. Jaruzelska, Jadwiga J and 5 more authors.. (2003) Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells.. Development genes and evolution, [PMID:12690449]
7. Dazard, Jean-Eudes JE and 5 more authors.. (2003) Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.. Oncogene, (15): [PMID:12771951]
8. Hillier, Ladeana W LW and 121 more authors.. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature, (7): [PMID:15815621]
9. Galgano, Alessia A and 5 more authors.. (2008) Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.. PloS one, (8): [PMID:18776931]
10. Ginter-Matuszewska, B B and 5 more authors.. (2009) The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells.. Molecular human reproduction, [PMID:19168546]
11. Mayya, Viveka V and 7 more authors.. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.. Science signaling, (18): [PMID:19690332]
12. Lu, Gang G and Hall, Traci M Tanaka TM.. (2011) Alternate modes of cognate RNA recognition by human PUMILIO proteins.. Structure (London, England : 1993), (9): [PMID:21397187]
13. Rigbolt, Kristoffer T G KT and 9 more authors.. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.. Science signaling, (15): [PMID:21406692]
14. Ginter-Matuszewska, Barbara B and 6 more authors.. (2011) NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.. Histochemistry and cell biology, [PMID:21800163]
15. Miles, Wayne O WO, Tschöp, Katrin K, Herr, Anabel A, Ji, Jun-Yuan JY and Dyson, Nicholas J NJ.. (2012) Pumilio facilitates miRNA regulation of the E2F3 oncogene.. Genes & development, (15): [PMID:22345517]
16. Van Etten, Jamie J and 6 more authors.. (2012) Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.. The Journal of biological chemistry, (19): [PMID:22955276]
17. Loedige, Inga I, Gaidatzis, Dimos D, Sack, Ragna R, Meister, Gunter G and Filipowicz, Witold W.. (2013) The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.. Nucleic acids research, (7): [PMID:23125361]
18. Narita, Ryo R and 7 more authors.. (2014) A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.. PLoS pathogens, [PMID:25340845]
19. Huang, Guochang G and 10 more authors.. (2014) SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).. The Journal of biological chemistry, (12): [PMID:25349211]
20. Lee, Sungyul S and 8 more authors.. (2016) Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.. Cell, (14): [PMID:26724866]
21. Treiber, Thomas T and 9 more authors.. (2017) A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.. Molecular cell, (20): [PMID:28431233]

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