Recombinant RanBP9 Antibody - Primary antibody, specific to RanBP9, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human RanBP9 Antibody; WB; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • WB
Item Number
Ab124531
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab124531-10μl
10μl
In stock
$69.90
Ab124531-50μl
50μl
In stock
$189.90
Ab124531-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab124531-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90

Recombinant; Rabbit anti Human RanBP9 Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant RanBP9 Antibody - Primary antibody, specific to RanBP9, Rabbit IgG
SynonymsB cell antigen receptor Ig beta associated protein 1 antibody | BPM 90 antibody | BPM L antibody | BPM-L antibody | BPM90 antibody | BPML antibody | IBAP 1antibody | Imp 9 antibody | Importin 9 antibody | Novel centrosomal protein RanBPM antibody | RAN bi
Specifications & PurityExactAb™, Validated, Recombinant, 0.5 mg/mL
Host speciesRabbit
SpecificityRanBP9
ImmunogenA synthetic peptide derived from human RanBP9 (AA 110-185)
Positive ControlWB: MOLT-4, U2OS, NIH/3T3 and C6 cell lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human RanBP9 Antibody, Recombinant, could be used for WB and so on.

Application:
WB: 1/500-1/1000

Protein Function:
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.5 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant RanBP9 Antibody (Ab124531) - Western Blot
All lanes: Recombinant RanBP9 Antibody (Ab124531) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 78 kDa
Observed band size: 88 kDa
Exposure time: 49.0 s

Associated Targets(Human)

RANBP9 Tbio Ran-binding protein 9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0505558Certificate of AnalysisMay 14, 2024 Ab124531
ZJ24F0505559Certificate of AnalysisMay 14, 2024 Ab124531

Related Documents

References

1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.  (2009)  Lysine acetylation targets protein complexes and co-regulates major cellular functions..  Science,  325  (5942): (834-40).  [PMID:19608861]
2. Nakamura, M M and 9 more authors..  (1998)  When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin..  The Journal of cell biology,    (16):   [PMID:9817760]
3. Nishitani, H H and 7 more authors..  (2001)  Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex..  Gene,    (11):   [PMID:11470507]
4. Ideguchi, Haruko H and 8 more authors..  (2002)  Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM..  The Biochemical journal,    (1):   [PMID:12084015]
5. Wang, Dakun D, Li, Zaibo Z, Messing, Edward M EM and Wu, Guan G..  (2002)  Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM..  The Journal of biological chemistry,    (27):   [PMID:12147692]
6. Wang, Ying Y and 5 more authors..  (2002)  HIPK2 associates with RanBPM..  Biochemical and biophysical research communications,    (13):   [PMID:12220523]
7. Rao, Mira A MA and 5 more authors..  (2002)  RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor..  The Journal of biological chemistry,    (13):   [PMID:12361945]
8. Emberley, Ethan D ED and 5 more authors..  (2002)  RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer..  BMC cancer,    (6):   [PMID:12421467]
9. Umeda, M M, Nishitani, H H and Nishimoto, T T..  (2003)  A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM..  Gene,    (16):   [PMID:12559565]
10. Lutz, Ward W and 7 more authors..  (2003)  Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy..  Biochemical and biophysical research communications,    (18):   [PMID:12684061]
11. Zou, Yonglong Y, Lim, Seunghwan S, Lee, Kangmoon K, Deng, Xiaobing X and Friedman, Eileen E..  (2003)  Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M..  The Journal of biological chemistry,    (5):   [PMID:14500717]
12. Mikolajczyk, Monika M, Shi, Jiaqi J, Vaillancourt, Richard R RR, Sachs, Nancy A NA and Nelson, Mark M..  (2003)  The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM..  Biochemical and biophysical research communications,    (10):   [PMID:14511641]
13. Wang, Dakun D, Li, Zaibo Z, Schoen, Susan R SR, Messing, Edward M EM and Wu, Guan G..  (2004)  A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling..  Biochemical and biophysical research communications,    (9):   [PMID:14684163]
14. Denti, Simona S and 8 more authors..  (2004)  RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1..  The Journal of biological chemistry,    (26):   [PMID:14722085]
15. Menon, Rajesh P RP, Gibson, Toby J TJ and Pastore, Annalisa A..  (2004)  The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre..  Journal of molecular biology,    (8):   [PMID:15381419]
16. Kramer, Sonja S and 5 more authors..  (2005)  Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells..  Oncogene,    (27):   [PMID:15558019]
17. Kobayashi, Nobuaki N and 7 more authors..  (2007)  RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex..  Gene,    (15):   [PMID:17467196]
18. Matsuoka, Shuhei S and 12 more authors..  (2007)  ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage..  Science (New York, N.Y.),    (25):   [PMID:17525332]
19. Harada, Naoki N, Yokoyama, Tsuyoshi T, Yamaji, Ryoichi R, Nakano, Yoshihisa Y and Inui, Hiroshi H..  (2008)  RanBP10 acts as a novel coactivator for the androgen receptor..  Biochemical and biophysical research communications,    (28):   [PMID:18222118]
20. Valiyaveettil, Manojkumar M and 7 more authors..  (2008)  Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation..  The Journal of cell biology,    (25):   [PMID:18710924]
21. Hosono, Katsuhiro K and 6 more authors..  (2010)  YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10..  Genomics,      [PMID:20580816]
22. Francis, Ore O, Han, Fujun F and Adams, Josephine C JC..  (2013)  Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex..  PloS one,      [PMID:24143168]
23. Hong, Seung Kon SK, Kim, Kook-Han KH, Song, Eun Joo EJ and Kim, Eunice EunKyeong EE..  (2016)  Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development..  Journal of molecular biology,    (23):   [PMID:27622290]
24. Lampert, Fabienne F and 8 more authors..  (2018)  The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation..  eLife,    (18):   [PMID:29911972]

Solution Calculators