A synthetic peptide derived from human Reelin (AA 3240-3300).
Positive Control
WB: Hep G2 and C6 cell lysates.
Conjugation
Unconjugated
Grade
ExactAb™, Recombinant, Validated
Product Description
Rabbit anti Human Reelin Antibody, Recombinant, could be used for WB and so on. Application WB: 1/500-1/2000 Protein Function Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
Product Properties
Isotype
Rabbit IgG
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
1.1 mg/mL
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant Reelin Antibody (Ab124937) - Western Blot All lanes: Recombinant Reelin Antibody (Ab124937) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 388 kDa Observed band size: 100, 388 kDa Exposure time: 100.0 s
1.Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R et al.. (2003) Human chromosome 7: DNA sequence and biology.. Science, 300 (5620):(767-72). [PMID:12690205]
2.DeSilva, U U and 6 more authors.. (1997) The human reelin gene: isolation, sequencing, and mapping on chromosome 7.. Genome research, [PMID:9049633]
3.Impagnatiello, F F and 13 more authors.. (1998) A decrease of reelin expression as a putative vulnerability factor in schizophrenia.. Proceedings of the National Academy of Sciences of the United States of America, (22):[PMID:9861036]
4.Lambert de Rouvroit, C C, Bernier, B B, Royaux, I I, de Bergeyck, V V and Goffinet, A M AM.. (1999) Evolutionarily conserved, alternative splicing of reelin during brain development.. Experimental neurology, [PMID:10328932]
5.Hong, S E SE and 7 more authors.. (2000) Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations.. Nature genetics, [PMID:10973257]
6.Persico, A M AM and 22 more authors.. (2001) Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder.. Molecular psychiatry, [PMID:11317216]
7.Hillier, Ladeana W LW and 106 more authors.. (2003) The DNA sequence of human chromosome 7.. Nature, (10):[PMID:12853948]
8.Dazzo, Emanuela E and 22 more authors.. (2015) Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy.. American journal of human genetics, (4):[PMID:26046367]
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