| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab125400-10μl | 10μl | In stock | $66.90 | |
| Ab125400-50μl | 50μl | In stock | $199.90 | |
| Ab125400-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $289.90 | |
| Ab125400-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,699.90 |
Recombinant; Rabbit anti Human RIP Antibody; WB; Unconjugated
| Product Name | Recombinant RIP Antibody - Primary antibody, specific to RIP, Rabbit IgG |
|---|---|
| Synonyms | AIEFL | IMD57 | Cell death protein RIP | EC 2.7.11.1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | receptor interacting protein | Receptor-interacting protein 1 | receptor-interacting serine/threonine-protein kinase 1 | RIP | Rip1 kinase | R |
| Specifications & Purity | ExactAb™, Validated, Recombinant, 0.2 mg/mL |
| Host species | Rabbit |
| Specificity | RIP |
| Immunogen | Recombinant protein of human RIP (AA 356-449) |
| Positive Control | WB: HEK293, K562, A549 and MCF7 cell lysates. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Recombinant, Validated |
| Product Description |
Rabbit anti Human RIP Antibody, Recombinant, could be used for WB and so on. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Antigen affinity purified |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Recombinant RIP Antibody (Ab125400) - Western Blot
All lanes: Recombinant RIP Antibody (Ab125400) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 76 kDa
Observed band size: 75 kDa
Exposure time: 33.6 s
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| WB | 1/500-1/2000 "> 1/500-1/2000 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0102604 | Certificate of Analysis | Jan 25, 2024 | Ab125400 |
| ZJ24F0102603 | Certificate of Analysis | Jan 25, 2024 | Ab125400 |
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| 5. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.. Cell, 137 (6): (1112-23). [PMID:19524513] [10.1021/op500134e] |
| 6. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.. Cell, 137 (6): (1100-11). [PMID:19524512] [10.1021/op500134e] |
| 7. Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X et al.. (2017) Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.. J Med Chem, 60 (4): (1247-1261). [PMID:28151659] [10.1021/op500134e] |
| 8. Ren Y, Su Y, Sun L, He S, Meng L, Liao D, Liu X, Ma Y, Liu C, Li S et al.. (2017) Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome.. J Med Chem, 60 (3): (972-986). [PMID:27992216] [10.1021/op500134e] |
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| 37. Stanger, B Z BZ, Leder, P P, Lee, T H TH, Kim, E E and Seed, B B.. (1995) RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.. Cell, (19): [PMID:7538908] |
| 38. Hsu, H H, Huang, J J, Shu, H B HB, Baichwal, V V and Goeddel, D V DV.. (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.. Immunity, [PMID:8612133] |
| 39. Ahmad, M M and 6 more authors.. (1997) CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.. Cancer research, (15): [PMID:9044836] |
| 40. Li, Y Y and 7 more authors.. (1999) Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:9927690] |
| 41. Sanz, L L, Sanchez, P P, Lallena, M J MJ, Diaz-Meco, M T MT and Moscat, J J.. (1999) The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.. The EMBO journal, (1): [PMID:10356400] |
| 42. Sun, X X and 5 more authors.. (1999) RIP3, a novel apoptosis-inducing kinase.. The Journal of biological chemistry, (11): [PMID:10358032] |
| 43. Izumi, K M KM and 5 more authors.. (1999) The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.. Molecular and cellular biology, [PMID:10409763] |
| 44. Lin, Y Y, Devin, A A, Rodriguez, Y Y and Liu, Z G ZG.. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.. Genes & development, (1): [PMID:10521396] |
| 45. Holler, N N and 9 more authors.. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.. Nature immunology, [PMID:11101870] |
| 46. Habib, A A AA and 5 more authors.. (2001) The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.. The Journal of biological chemistry, (23): [PMID:11116146] |
| 47. Sun, Xiaoqing X, Yin, Jianping J, Starovasnik, Melissa A MA, Fairbrother, Wayne J WJ and Dixit, Vishva M VM.. (2002) Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.. The Journal of biological chemistry, (15): [PMID:11734559] |
| 48. Chen, Danying D, Li, Xiaoyan X, Zhai, Zhonghe Z and Shu, Hong-Bing HB.. (2002) A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation.. The Journal of biological chemistry, (3): [PMID:11854271] |
| 49. Huang, Jun J and 8 more authors.. (2004) ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.. The Journal of biological chemistry, (16): [PMID:14754897] |
| 50. Brill, Laurence M LM and 5 more authors.. (2004) Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.. Analytical chemistry, (15): [PMID:15144186] |
| 51. Wertz, Ingrid E IE and 12 more authors.. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.. Nature, (5): [PMID:15258597] |
| 52. Zhang, Haifeng H and 5 more authors.. (2004) AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.. The Journal of biological chemistry, (22): [PMID:15310755] |
| 53. Kawai, Taro T and 8 more authors.. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.. Nature immunology, [PMID:16127453] |
| 54. Ea, Chee-Kwee CK, Deng, Li L, Xia, Zong-Ping ZP, Pineda, Gabriel G and Chen, Zhijian J ZJ.. (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.. Molecular cell, (21): [PMID:16603398] |
| 55. Festjens, N N, Vanden Berghe, T T, Cornelis, S S and Vandenabeele, P P.. (2007) RIP1, a kinase on the crossroads of a cell's decision to live or die.. Cell death and differentiation, [PMID:17301840] |
| 56. Zhang, Haifeng H and 6 more authors.. (2007) RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.. The Journal of biological chemistry, (18): [PMID:17389591] |
| 57. Tian, Yang Y and 9 more authors.. (2007) RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.. The Journal of biological chemistry, (8): [PMID:17449468] |
| 58. Shembade, Noula N, Harhaj, Nicole S NS, Liebl, Daniel J DJ and Harhaj, Edward W EW.. (2007) Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.. The EMBO journal, (5): [PMID:17703191] |
| 59. Upton, Jason W JW, Kaiser, William J WJ and Mocarski, Edward S ES.. (2008) Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1.. The Journal of biological chemistry, (20): [PMID:18442983] |
| 60. Liao, Wentao W and 10 more authors.. (2008) CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.. Current biology : CB, (6): [PMID:18450452] |
| 61. Vandenabeele, Peter P, Declercq, Wim W, Van Herreweghe, Franky F and Vanden Berghe, Tom T.. (2010) The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.. Science signaling, (30): [PMID:20354226] |
| 62. Gerlach, Björn B and 15 more authors.. (2011) Linear ubiquitination prevents inflammation and regulates immune signalling.. Nature, (31): [PMID:21455173] |
| 63. Zhao, Yun Y and 10 more authors.. (2012) Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.. Inflammatory bowel diseases, [PMID:21887730] |
| 64. Bertrand, Mathieu J M MJ and 8 more authors.. (2011) cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).. PloS one, [PMID:21931591] |
| 65. Wang, Zhigao Z, Jiang, Hui H, Chen, She S, Du, Fenghe F and Wang, Xiaodong X.. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.. Cell, (20): [PMID:22265414] |
| 66. van Raam, B J BJ, Ehrnhoefer, D E DE, Hayden, M R MR and Salvesen, G S GS.. (2013) Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.. Cell death and differentiation, [PMID:22858542] |
| 67. Li, Shan S and 11 more authors.. (2013) Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.. Nature, (12): [PMID:23955153] |
| 68. Kim, Tae Woo TW and 14 more authors.. (2014) SH3RF2 functions as an oncogene by mediating PAK4 protein stability.. Carcinogenesis, [PMID:24130170] |
| 69. Zaman, Mohammad Mahabub-Uz MM and 7 more authors.. (2013) Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis.. Molecular and cellular biology, [PMID:24144979] |
| 70. Weinlich, Ricardo R and Green, Douglas R DR.. (2014) The two faces of receptor interacting protein kinase-1.. Molecular cell, (20): [PMID:25459879] |
| 71. Guo, Hongyan H and 7 more authors.. (2015) Herpes simplex virus suppresses necroptosis in human cells.. Cell host & microbe, (11): [PMID:25674983] |
| 72. Hu, Yun-Hong YH and 7 more authors.. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF.. EMBO reports, [PMID:25736436] |
| 73. Franz, Stephanie S and 9 more authors.. (2017) Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes.. Journal of virology, (15): [PMID:28659487] |
| 74. Meng, Huyan H and 11 more authors.. (2018) Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.. Proceedings of the National Academy of Sciences of the United States of America, (27): [PMID:29440439] |
| 75. Mompeán, Miguel M and 7 more authors.. (2018) The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.. Cell, (17): [PMID:29681455] |
| 76. Choi, Seung-Won SW and 10 more authors.. (2018) PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.. Molecular cell, (7): [PMID:29883609] |
| 77. Ang, Rosalind L; Chan, Mark and Ting, Adrian T.. (2019) Ripoptocide - A Spark for Inflammation.. Frontiers in cell and developmental biology, [PMID:31457011] |
