Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Ab126946-10μl | 10μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
Ab126946-50μl | 50μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
Ab126946-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $309.90 | |
Ab126946-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,199.90 |
Recombinant; Rabbit anti Human Securin Antibody; WB; Unconjugated
Product Name | Recombinant Securin Antibody - Primary antibody, specific to Securin, Rabbit IgG |
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Synonyms | EAP1; ECRAR; HPTTG; PTTG; TUTR1; AW555095 antibody; C87862 antibody; Cut2 antibody; EAP 1 antibody; EAP1 antibody; ESP1 associated protein 1 antibody; Esp1-associated protein antibody; hPTTG antibody; MGC126883 antibody; MGC138276 antibody; Pds1 antibody; |
Specifications & Purity | Recombinant, ExactAb™, Validated, See COA |
Biochemical and Physiological Mechanisms | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the |
Host species | Rabbit |
Specificity | Securin |
Immunogen | A synthetic peptide derived from human Securin (AA 100-149) |
Positive Control | WB: HeLa, Raji and NIH/3T3 cell lysates. |
Conjugation | Unconjugated |
Grade | ExactAb™, Recombinant, Validated |
Product Description | Rabbit anti Human Securin Antibody, Recombinant, could be used for WB and so on. |
Isotype | Rabbit IgG |
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Light Chain Type | kappa |
SDS-PAGE | 150 kDa |
Purification Method | Protein A purified |
Form | Liquid |
Concentration | See COA |
Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Application | Dilution info |
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WB | 1/1000 - 1/2000"> 1/1000 - 1/2000 |
Enter Lot Number to search for COA:
1. Domínguez, A A and 6 more authors.. (1998) hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG.. Oncogene, (29): [PMID:9811450] |
2. Zhang, X X and 6 more authors.. (1999) Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).. Molecular endocrinology (Baltimore, Md.), [PMID:9892021] |
3. Zhang, X X and 6 more authors.. (1999) Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas.. The Journal of clinical endocrinology and metabolism, [PMID:10022450] |
4. Kakar, S S SS and Jennes, L L.. (1999) Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.. Cytogenetics and cell genetics, [PMID:10393434] |
5. Zou, H H, McGarry, T J TJ, Bernal, T T and Kirschner, M W MW.. (1999) Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.. Science (New York, N.Y.), (16): [PMID:10411507] |
6. and Kakar, S S SS.. (1999) Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG).. Gene, (29): [PMID:10580151] |
7. Ramos-Morales, F F and 6 more authors.. (2000) Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.. Oncogene, (20): [PMID:10656688] |
8. Chien, W W and Pei, L L.. (2000) A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product.. The Journal of biological chemistry, (23): [PMID:10781616] |
9. Ishikawa, H H, Heaney, A P AP, Yu, R R, Horwitz, G A GA and Melmed, S S.. (2001) Human pituitary tumor-transforming gene induces angiogenesis.. The Journal of clinical endocrinology and metabolism, [PMID:11158059] |
10. Romero, F F and 6 more authors.. (2001) Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.. Nucleic acids research, (15): [PMID:11238996] |
11. Jallepalli, P V PV and 8 more authors.. (2001) Securin is required for chromosomal stability in human cells.. Cell, (18): [PMID:11371342] |
12. Bernal, Juan A JA and 9 more authors.. (2002) Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.. Nature genetics, [PMID:12355087] |
13. Jin, Lingyan L, Williamson, Adam A, Banerjee, Sudeep S, Philipp, Isabelle I and Rape, Michael M.. (2008) Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.. Cell, (16): [PMID:18485873] |
14. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378] |