Recombinant Securin Antibody - Primary antibody, specific to Securin, Rabbit IgG

    Application:
  • WB
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab126946
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab126946-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab126946-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
Ab126946-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab126946-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,199.90

Recombinant; Rabbit anti Human Securin Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant Securin Antibody - Primary antibody, specific to Securin, Rabbit IgG
SynonymsEAP1; ECRAR; HPTTG; PTTG; TUTR1; AW555095 antibody; C87862 antibody; Cut2 antibody; EAP 1 antibody; EAP1 antibody; ESP1 associated protein 1 antibody; Esp1-associated protein antibody; hPTTG antibody; MGC126883 antibody; MGC138276 antibody; Pds1 antibody;
Specifications & PurityRecombinant, ExactAb™, Validated, See COA
Biochemical and Physiological MechanismsRegulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the
Host speciesRabbit
SpecificitySecurin
ImmunogenA synthetic peptide derived from human Securin (AA 100-149)
Positive ControlWB: HeLa, Raji and NIH/3T3 cell lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Securin Antibody, Recombinant, could be used for WB and so on.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
ConcentrationSee COA
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PTTG1 Tbio Securin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB1/1000 - 1/2000

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1/1000 - 1/2000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

References

1. Domínguez, A A and 6 more authors..  (1998)  hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG..  Oncogene,    (29):   [PMID:9811450]
2. Zhang, X X and 6 more authors..  (1999)  Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)..  Molecular endocrinology (Baltimore, Md.),      [PMID:9892021]
3. Zhang, X X and 6 more authors..  (1999)  Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas..  The Journal of clinical endocrinology and metabolism,      [PMID:10022450]
4. Kakar, S S SS and Jennes, L L..  (1999)  Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis..  Cytogenetics and cell genetics,      [PMID:10393434]
5. Zou, H H, McGarry, T J TJ, Bernal, T T and Kirschner, M W MW..  (1999)  Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis..  Science (New York, N.Y.),    (16):   [PMID:10411507]
6. and Kakar, S S SS..  (1999)  Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)..  Gene,    (29):   [PMID:10580151]
7. Ramos-Morales, F F and 6 more authors..  (2000)  Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product..  Oncogene,    (20):   [PMID:10656688]
8. Chien, W W and Pei, L L..  (2000)  A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product..  The Journal of biological chemistry,    (23):   [PMID:10781616]
9. Ishikawa, H H, Heaney, A P AP, Yu, R R, Horwitz, G A GA and Melmed, S S..  (2001)  Human pituitary tumor-transforming gene induces angiogenesis..  The Journal of clinical endocrinology and metabolism,      [PMID:11158059]
10. Romero, F F and 6 more authors..  (2001)  Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase..  Nucleic acids research,    (15):   [PMID:11238996]
11. Jallepalli, P V PV and 8 more authors..  (2001)  Securin is required for chromosomal stability in human cells..  Cell,    (18):   [PMID:11371342]
12. Bernal, Juan A JA and 9 more authors..  (2002)  Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis..  Nature genetics,      [PMID:12355087]
13. Jin, Lingyan L, Williamson, Adam A, Banerjee, Sudeep S, Philipp, Isabelle I and Rape, Michael M..  (2008)  Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex..  Cell,    (16):   [PMID:18485873]
14. Van Damme, Petra P and 15 more authors..  (2012)  N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB..  Proceedings of the National Academy of Sciences of the United States of America,    (31):   [PMID:22814378]

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