1. Burke TR, Barchi JJ, George C, Wolf G, Shoelson SE, Yan X.. (1995) Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors.. J Med Chem, 38 (8): (1386-1396). [PMID:7537333] [10.1021/jm00008a017] |
2. Liljebris C, Larsen SD, Ogg D, Palazuk BJ, Bleasdale JE.. (2002) Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.. J Med Chem, 45 (9): (1785-1798). [PMID:11960490] [10.1021/jm011100y] |
3. Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R et al.. (2008) Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.. J Med Chem, 51 (18): (5650-62). [PMID:18759424] [10.1021/op500134e] |
4. He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N et al.. (2013) A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.. J Med Chem, 56 (12): (4990-5008). [PMID:23713581] [10.1021/op500134e] |
5. Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.. Proc Natl Acad Sci USA, 104 (50): (19767-72). [PMID:18056643] [10.1021/op500134e] |
6. Angst D, Gessier F, Janser P, Vulpetti A, Wälchli R, Beerli C, Littlewood-Evans A, Dawson J, Nuesslein-Hildesheim B, Wieczorek G et al.. (2020) Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.. J Med Chem, 63 (10): (5102-5118). [PMID:32083858] [10.1021/op500134e] |
7. Lan Chen, Bo Zhou, Sheng Zhang, Li Wu, Yuehong Wang, Scott G Franzblau, Zhong-Yin Zhang,. (2010-12-01) Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.. ACS medicinal chemistry letters, 1 ((7)): ( 355-359 ). [PMID:21116447] |
8. Latanya M Scott,Liwei Chen,Kenyon G Daniel,Wesley H Brooks,Wayne C Guida,Harshani R Lawrence,Said M Sebti,Nicholas J Lawrence,Jie Wu. (2011-01-05) Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.. Bioorganic & medicinal chemistry letters, 21 ((2)): (730-733). [PMID:21193311] |
9. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed. (2009-05-06) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.. Analytical chemistry, 81 ((11)): (4493-4501). [PMID:19413330] |
10. Hai-Bing He,Li-Xin Gao,Qi-Feng Deng,Wei-Ping Ma,Chun-Lan Tang,Wen-Wei Qiu,Jie Tang,Jing-Ya Li,Jia Li,Fan Yang. (2012-10-17) Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.. Bioorganic & medicinal chemistry letters, 22 ((23)): (7237-7242). [PMID:23067554] |
11. Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP.. (2007) An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.. J Med Chem, 50 (11): (2622-2639). [PMID:17489579] [10.1021/jm0613323] |
12. Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ.. (2008) Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.. J Med Chem, 51 (16): (4948-4956). [PMID:18680359] [10.1021/jm8002526] |
13. Geronikaki A, Eleftheriou P, Vicini P, Alam I, Dixit A, Saxena AK.. (2008) 2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action.. J Med Chem, 51 (17): (5221-5228). [PMID:18702480] [10.1021/jm8004306] |
14. Yu WM, Guvench O, Mackerell AD, Qu CK.. (2008) Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay.. J Med Chem, 51 (23): (7396-7404). [PMID:19007293] [10.1021/jm800229d] |
15. Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY.. (2010) Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).. J Med Chem, 53 (6): (2482-2493). [PMID:20170098] [10.1021/jm901645u] |
16. Bhattacharyya S, Zhou H, Seiner DR, Gates KS.. (2010) Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.. Bioorg Med Chem, 18 (16): (5945-5949). [PMID:20655236] [10.1016/j.bmc.2010.06.084] |
17. Baumgartner RR, Steinmann D, Heiss EH, Atanasov AG, Ganzera M, Stuppner H, Dirsch VM.. (2010) Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.. J Nat Prod, 73 (9): (1578-1581). [PMID:20806783] [10.1021/np100258e] |
18. Bu Y, Shi T, Meng M, Kong G, Tian Y, Chen Q, Yao X, Feng G, Chen H, Lu Z.. (2011) A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.. Bioorg Med Chem Lett, 21 (2): (874-878). [PMID:21169016] [10.1016/j.bmcl.2010.11.049] |
19. Yang JW, He XP, Li C, Gao LX, Sheng L, Xie J, Shi XX, Tang Y, Li J, Chen GR.. (2011) A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.. Bioorg Med Chem Lett, 21 (4): (1092-1096). [PMID:21251827] [10.1016/j.bmcl.2010.12.126] |
20. Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY.. (2011) Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.. Bioorg Med Chem Lett, 21 (14): (4238-4242). [PMID:21669525] [10.1016/j.bmcl.2011.05.078] |
21. He Y, Zeng LF, Yu ZH, He R, Liu S, Zhang ZY.. (2012) Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.. Bioorg Med Chem, 20 (6): (1940-1946). [PMID:22133902] [10.1016/j.bmc.2011.11.004] |
22. He Y, Xu J, Yu ZH, Gunawan AM, Wu L, Wang L, Zhang ZY.. (2013) Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.. J Med Chem, 56 (3): (832-842). [PMID:23305444] [10.1021/jm301781p] |
23. Liu W, Yu B, Xu G, Xu WR, Loh ML, Tang LD, Qu CK.. (2013) Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).. J Med Chem, 56 (18): (7212-7221). [PMID:23957426] [10.1021/jm400474r] |
24. Chen YT, Tang CL, Ma WP, Gao LX, Wei Y, Zhang W, Li JY, Li J, Nan FJ.. (2013) Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.. Eur J Med Chem, 69 (399-412). [PMID:24090912] [10.1016/j.ejmech.2013.09.017] |
25. Zhi Y, Gao LX, Jin Y, Tang CL, Li JY, Li J, Long YQ.. (2014) 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.. Bioorg Med Chem, 22 (14): (3670-3683). [PMID:24906513] [10.1016/j.bmc.2014.05.028] |
26. Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, Lane BS, Mali RS, Li X, Chan RJ, Kapur R, Wells CD, Zhang ZY.. (2014) Therapeutic potential of targeting the oncogenic SHP2 phosphatase.. J Med Chem, 57 (15): (6594-6609). [PMID:25003231] [10.1021/jm5006176] |
27. Sasaki T, Li W, Higai K, Koike K.. (2015) Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.. Bioorg Med Chem Lett, 25 (9): (1979-1981). [PMID:25819098] [10.1016/j.bmcl.2015.03.014] |
28. He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY.. (2015) A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.. Bioorg Med Chem, 23 (12): (2798-2809). [PMID:25907364] [10.1016/j.bmc.2015.03.066] |
29. Tautz L, Senis YA, Oury C, Rahmouni S.. (2015) Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.. Bioorg Med Chem, 23 (12): (2786-2797). [PMID:25921264] [10.1016/j.bmc.2015.03.075] |
30. Jiang B, Pei D.. (2015) A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl-Prolyl Isomerase Pin1.. J Med Chem, 58 (15): (6306-6312). [PMID:26196061] [10.1021/acs.jmedchem.5b00411] |
31. He R, Bai Y, Yu ZH, Wu L, Gunawan AM, Zhang ZY.. (2014) Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.. Medchemcomm, 5 (10): (1496-1499). [PMID:25505942] [10.1039/c4md00099d] |
32. Liu P, Du Y, Song L, Shen J, Li Q.. (2015) Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.. Bioorg Med Chem, 23 (21): (7079-7088). [PMID:26481657] [10.1016/j.bmc.2015.09.024] |
33. Liu P, Du Y, Song L, Shen J, Li Q.. (2016) Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.. Eur J Med Chem, 118 (27-33). [PMID:27123900] [10.1016/j.ejmech.2016.04.014] |
34. Li Y, Xia G, Guo Q, Wu L, Chen S, Yang Z, Wang W, Zhang ZY, Zhou X, Jiang ZX.. (2016) Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.. Medchemcomm, 7 (8): (1672-1680). [PMID:27529021] [10.1039/C6MD00277C] |
35. Xie J, Si X, Gu S, Wang M, Shen J, Li H, Shen J, Li D, Fang Y, Liu C, Zhu J.. (2017) Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.. J Med Chem, 60 (24): (10205-10219). [PMID:29155585] [10.1021/acs.jmedchem.7b01520] |
36. Sun W, Zhuang C, Li X, Zhang B, Lu X, Zheng Z, Dong Y.. (2017) Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.. Bioorg Med Chem Lett, 27 (15): (3382-3385). [PMID:28642102] [10.1016/j.bmcl.2017.06.001] |
37. Du Y, Zhang Y, Ling H, Li Q, Shen J.. (2018) Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.. Eur J Med Chem, 144 (692-700). [PMID:29289892] [10.1016/j.ejmech.2017.12.064] |
38. LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC.. (2017) Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.. Bioorg Med Chem, 25 (24): (6479-6485). [PMID:29089257] [10.1016/j.bmc.2017.10.025] |
39. Wang WL, Chen XY, Gao Y, Gao LX, Sheng L, Zhu J, Xu L, Ding ZZ, Zhang C, Li JY, Li J, Zhou YB.. (2017) Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.. Bioorg Med Chem Lett, 27 (23): (5154-5157). [PMID:29100798] [10.1016/j.bmcl.2017.10.059] |
40. Zhang J, Sasaki T, Li W, Nagata K, Higai K, Feng F, Wang J, Cheng M, Koike K.. (2018) Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.. Bioorg Med Chem Lett, 28 (7): (1194-1197). [PMID:29525218] [10.1016/j.bmcl.2018.02.052] |
41. Kim B, Jo S, Park SB, Chae CH, Lee K, Koh B, Shin I.. (2020) Development and structure-activity relationship study of SHP2 inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene.. Bioorg Med Chem Lett, 30 (1): (126756-126756). [PMID:31784318] [10.1016/j.bmcl.2019.126756] |
42. Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC.. (2018) Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.. J Med Chem, 61 (24): (11144-11157). [PMID:30525586] [10.1021/acs.jmedchem.8b01224] |
43. Li X, Xu Q, Li C, Luo J, Li X, Wang L, Jiang B, Shi D.. (2019) Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.. Eur J Med Chem, 166 (178-185). [PMID:30711829] [10.1016/j.ejmech.2019.01.057] |
44. Jiao WH, Li J, Wang D, Zhang MM, Liu LY, Sun F, Li JY, Capon RJ, Lin HW.. (2019) Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea.. J Nat Prod, 82 (9): (2586-2593). [PMID:31532203] [10.1021/acs.jnatprod.9b00471] |
45. Wu X, Xu G, Li X, Xu W, Li Q, Liu W, Kirby KA, Loh ML, Li J, Sarafianos SG, Qu CK.. (2019) Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.. J Med Chem, 62 (3): (1125-1137). [PMID:30457860] [10.1021/acs.jmedchem.8b00513] |
46. Xie F, Yang F, Liang Y, Li L, Xia Y, Jiang F, Liu W, Qi Y, Chowdhury SR, Xie D, Fu L.. (2019) Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.. Eur J Med Chem, 164 (408-422). [PMID:30611982] [10.1016/j.ejmech.2018.12.032] |
47. Wang M, Lu J, Wang M, Yang CY, Wang S.. (2020) Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein.. J Med Chem, 63 (14): (7510-7528). [PMID:32437146] [10.1021/acs.jmedchem.0c00471] |
48. Yuan X,Bu H,Zhou J,Yang CY,Zhang H. (2020) Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.. J Med Chem, 63 (20.0): (11368-11396). [PMID:32460492] [10.1021/acs.jmedchem.0c00249] |
49. He R,Wang J,Yu ZH,Zhang RY,Liu S,Wu L,Zhang ZY. (2016) Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.. J Med Chem, 59 (19.0): (9094-9106). [PMID:27676368] [10.1021/acs.jmedchem.6b00993] |
50. Freeman, R M RM, Plutzky, J J and Neel, B G BG.. (1992) Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:1280823] |
51. Adachi, M M and 6 more authors.. (1992) Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.. FEBS letters, (21): [PMID:1281790] |
52. Vogel, W W, Lammers, R R, Huang, J J and Ullrich, A A.. (1993) Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.. Science (New York, N.Y.), (12): [PMID:7681217] |
53. Ahmad, S S, Banville, D D, Zhao, Z Z, Fischer, E H EH and Shen, S H SH.. (1993) A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7681589] |
54. Lechleider, R J RJ and 7 more authors.. (1993) Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.. The Journal of biological chemistry, (15): [PMID:7691811] |
55. Bennett, A M AM, Tang, T L TL, Sugimoto, S S, Walsh, C T CT and Neel, B G BG.. (1994) Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.. Proceedings of the National Academy of Sciences of the United States of America, (19): [PMID:8041791] |
56. Bastien, L L, Ramachandran, C C, Liu, S S and Adam, M M.. (1993) Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase.. Biochemical and biophysical research communications, (15): [PMID:8216283] |
57. Ohnishi, H H, Kubota, M M, Ohtake, A A, Sato, K K and Sano, S i Si.. (1996) Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.. The Journal of biological chemistry, (11): [PMID:8810330] |
58. Kharitonenkov, A A and 5 more authors.. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors.. Nature, (13): [PMID:9062191] |
59. Hof, P P, Pluskey, S S, Dhe-Paganon, S S, Eck, M J MJ and Shoelson, S E SE.. (1998) Crystal structure of the tyrosine phosphatase SHP-2.. Cell, (20): [PMID:9491886] |
60. Igarashi, K K and 5 more authors.. (1998) Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.. Biochemical and biophysical research communications, (8): [PMID:9600074] |
61. Nishida, K K and 10 more authors.. (1999) Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.. Blood, (15): [PMID:10068651] |
62. Marie-Cardine, A A and 8 more authors.. (1999) SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.. The Journal of experimental medicine, (19): [PMID:10209036] |
63. Miao, H H, Burnett, E E, Kinch, M M, Simon, E E and Wang, B B.. (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.. Nature cell biology, [PMID:10655584] |
64. Zhao, R R and Zhao, Z J ZJ.. (2000) Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.. The Journal of biological chemistry, (25): [PMID:10681522] |
65. Xu , M J MJ, Zhao, R R and Zhao, Z J ZJ.. (2001) Molecular cloning and characterization of SPAP1, an inhibitory receptor.. Biochemical and biophysical research communications, (26): [PMID:11162587] |
66. Sayós, J J and 7 more authors.. (2001) Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.. Blood, (15): [PMID:11389028] |
67. Lewis, J J and 7 more authors.. (2001) Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.. Clinical immunology (Orlando, Fla.), [PMID:11414741] |
68. Pfrepper, K I KI and 8 more authors.. (2001) Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).. European journal of immunology, [PMID:11433379] |
69. Tartaglia, M M and 13 more authors.. (2001) Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.. Nature genetics, [PMID:11704759] |
70. Tartaglia, Marco M and 13 more authors.. (2002) PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.. American journal of human genetics, [PMID:11992261] |
71. Digilio, Maria Cristina MC and 7 more authors.. (2002) Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene.. American journal of human genetics, [PMID:12058348] |
72. Kosaki, Kenjiro K and 9 more authors.. (2002) PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome.. The Journal of clinical endocrinology and metabolism, [PMID:12161469] |
73. Maheshwari, M M and 10 more authors.. (2002) PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13.. Human mutation, [PMID:12325025] |
74. Schollen, Els E, Matthijs, Gert G, Gewillig, Marc M, Fryns, Jean-Pierre JP and Legius, Eric E.. (2003) PTPN11 mutation in a large family with Noonan syndrome and dizygous twinning.. European journal of human genetics : EJHG, [PMID:12529711] |
75. Musante, Luciana L and 11 more authors.. (2003) Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome.. European journal of human genetics : EJHG, [PMID:12634870] |
76. Tartaglia, Marco M and 9 more authors.. (2003) Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.. Nature genetics, [PMID:12717436] |
77. Kondoh, Tatsuro T and 6 more authors.. (2003) Noonan syndrome with leukaemoid reaction and overproduction of catecholamines: a case report.. European journal of pediatrics, [PMID:12739139] |
78. Sarkozy, A A and 10 more authors.. (2003) Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.. Journal of medical genetics, [PMID:12960218] |
79. Kogata, Naoko N and 6 more authors.. (2003) Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells.. Molecular biology of the cell, [PMID:12972546] |
80. Ehrhardt, Gotz R A GR and 5 more authors.. (2003) The inhibitory potential of Fc receptor homolog 4 on memory B cells.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:14597715] |
81. Conti, E E and 6 more authors.. (2003) A novel PTPN11 mutation in LEOPARD syndrome.. Human mutation, [PMID:14961557] |
82. Wang, Jian Feng JF, Zhang, Xuefeng X and Groopman, Jerome E JE.. (2004) Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.. The Journal of biological chemistry, (25): [PMID:15102829] |
83. Sarkozy, A A and 9 more authors.. (2004) Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome.. Journal of medical genetics, [PMID:15121796] |
84. Bertola, Débora Romeo DR, Pereira, Alexandre C AC, de Oliveira, Paulo S L PS, Kim, Chong A CA and Krieger, José Eduardo JE.. (2004) Clinical variability in a Noonan syndrome family with a new PTPN11 gene mutation.. American journal of medical genetics. Part A, (1): [PMID:15384080] |
85. Yoshida, Rie R and 5 more authors.. (2004) Two novel and one recurrent PTPN11 mutations in LEOPARD syndrome.. American journal of medical genetics. Part A, (1): [PMID:15389709] |
86. Keren, B B and 17 more authors.. (2004) PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience.. Journal of medical genetics, [PMID:15520399] |
87. Rönnstrand, L L.. (2004) Signal transduction via the stem cell factor receptor/c-Kit.. Cellular and molecular life sciences : CMLS, [PMID:15526160] |
88. Rush, John J and 9 more authors.. (2005) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.. Nature biotechnology, [PMID:15592455] |
89. Kalidas, Kamini K and 9 more authors.. (2005) Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11.. Journal of human genetics, [PMID:15690106] |
90. Takahashi, Kunihiko K and 9 more authors.. (2005) A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy.. European journal of pediatrics, [PMID:15889278] |
91. Bertola, Debora R DR and 7 more authors.. (2005) Neurofibromatosis-Noonan syndrome: molecular evidence of the concurrence of both disorders in a patient.. American journal of medical genetics. Part A, (30): [PMID:15948193] |
92. Uçar, Canan C, Calýskan, Umran U, Martini, Susanne S and Heinritz, Wolfram W.. (2006) Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive).. Journal of pediatric hematology/oncology, [PMID:16679933] |
93. Digilio, M Cristina MC and 5 more authors.. (2006) PTPN11 gene mutations: linking the Gln510Glu mutation to the "LEOPARD syndrome phenotype".. European journal of pediatrics, [PMID:16733669] |
94. Charest, Al A and 11 more authors.. (2006) ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.. Cancer research, (1): [PMID:16885344] |
95. Traina, Fabíola F and 6 more authors.. (2006) ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells.. Biochimica et biophysica acta, [PMID:16956752] |
96. Wilson, Timothy J TJ and 5 more authors.. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.. Blood, (1): [PMID:17213291] |
97. Hoffmann, Sabrina C SC and 7 more authors.. (2007) Identification of CLEC12B, an inhibitory receptor on myeloid cells.. The Journal of biological chemistry, (3): [PMID:17562706] |
98. Lee, Hsiao-Hui HH and Chang, Zee-Fen ZF.. (2008) Regulation of RhoA-dependent ROCKII activation by Shp2.. The Journal of cell biology, (16): [PMID:18559669] |
99. Yu, Ming-Can MC and 14 more authors.. (2008) An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.. Nature immunology, [PMID:18604210] |
100. Jakob, Sascha S and 6 more authors.. (2008) Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.. The Journal of biological chemistry, (28): [PMID:18829466] |
101. Ko, Jung Min JM, Kim, Jae-Min JM, Kim, Gu-Hwan GH and Yoo, Han-Wook HW.. (2008) PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.. Journal of human genetics, [PMID:19020799] |
102. Barr, Alastair J AJ and 9 more authors.. (2009) Large-scale structural analysis of the classical human protein tyrosine phosphatome.. Cell, (23): [PMID:19167335] |
103. Yo, Koji K and 9 more authors.. (2009) SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration.. Biochemical and biophysical research communications, (24): [PMID:19275884] |
104. Dasgupta, Bidisha B, Dufour, Eric E, Mamdouh, Zahra Z and Muller, William A WA.. (2009) A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:19342684] |
105. Tashiro, Kyoko K and 7 more authors.. (2009) GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.. The Journal of biological chemistry, (24): [PMID:19509291] |
106. Mayya, Viveka V and 7 more authors.. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.. Science signaling, (18): [PMID:19690332] |
107. Kochi, Yuta Y and 6 more authors.. (2009) FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:19843936] |
108. Sobreira, Nara L M NL and 15 more authors.. (2010) Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene.. PLoS genetics, (17): [PMID:20577567] |
109. Mazharian, Alexandra A and 14 more authors.. (2012) Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.. Science signaling, (30): [PMID:23112346] |
110. Edwards, Jonathan J JJ and 8 more authors.. (2014) A PTPN11 allele encoding a catalytically impaired SHP2 protein in a patient with a Noonan syndrome phenotype.. American journal of medical genetics. Part A, [PMID:24891296] |
111. Noda, Saori S, Takahashi, Atsushi A, Hayashi, Takeru T, Tanuma, Sei-ichi S and Hatakeyama, Masanori M.. (2016) Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.. Biochemical and biophysical research communications, (22): [PMID:26742426] |
112. Pannone, Luca L and 28 more authors.. (2017) Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome.. Human mutation, [PMID:28074573] |
113. Bongard, Robert D RD and 10 more authors.. (2017) Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.. BMC biochemistry, (31): [PMID:28569147] |