Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Ab127656-10μl | 10μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
Ab127656-50μl | 50μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $169.90 | |
Ab127656-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $249.90 | |
Ab127656-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,299.90 |
Recombinant; Rabbit anti Human SIRT1 Antibody; WB, IHC, IF/ICC, IP; Unconjugated
Product Name | SIRT1 Antibody - Primary antibody, specific to SIRT1, Rabbit IgG |
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Synonyms | 2.3.1.- | EC 2.3.1.286 | hSIR2 | hSIRT1 | NAD-dependent protein deacylase sirtuin-1 | Regulatory protein SIR2 homolog 1 | SIR2-like protein 1 | EC 3.5.1 | S. cerevisiae, homolog) 1 | SIR2alpha | SIR2L1 | SIR2-like protein 1 | SIRT1 | Sirtuin 1 | SIR2 | 75 |
Specifications & Purity | ExactAb™, Validated, Recombinant, Lot by Lot |
Host species | Rabbit |
Specificity | SIRT1 |
Immunogen | A synthetic peptide derived from human SIRT1(AA 700-740) |
Positive Control | WB: A549, HeLa, K562, MCF7, Jurkat and Hep G2 cell lysates. IHC: Rat stomach, Human pituitary tumor, Human colon, Human placenta, Mouse lung, Human kidney tissue. IF/ICC: HeLa cells. IP: HeLa lysates. |
Conjugation | Unconjugated |
Grade | ExactAb™, Recombinant, Validated |
Product Description |
Rabbit anti Human SIRT1 Antibody, Recombinant, could be used for WB, IHC, IF/ICC, IP and so on. |
Isotype | Rabbit IgG |
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Light Chain Type | kappa |
SDS-PAGE | 150 kDa |
Purification Method | Protein A purified |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Application | Dilution info |
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WB | 1/500-1/2000 "> 1/500-1/2000 |
IF/ICC | 1/50 - 1/200 "> 1/50 - 1/200 |
IHC | 1/50-1/200 "> 1/50-1/200 |
IP | 1/30 "> 1/30 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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ZJ24F0708453 | Certificate of Analysis | Jul 17, 2024 | Ab127656 |
ZJ24F0708452 | Certificate of Analysis | Jul 17, 2024 | Ab127656 |
1. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB et al.. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.. Nature, 450 (7170): (712-6). [PMID:18046409] [10.1021/op500134e] |
2. Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ et al.. (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.. Science, 317 (5837): (516-9). [PMID:17588900] [10.1021/op500134e] |
3. Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ. (2006) Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.. Mol Cell Biol, 26 (1): (28-38). [PMID:16354677] [10.1021/op500134e] |
4. Pasco MY, Rotili D, Altucci L, Farina F, Rouleau GA, Mai A, Néri C. (2010) Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.. J Med Chem, 53 (3): (1407-11). [PMID:20041717] [10.1021/op500134e] |
5. Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M. (2012) Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.. ACS Med Chem Lett, 3 (12): (1050-3). [PMID:24900427] [10.1021/op500134e] |
6. Cai X, Zhai HX, Wang J, Forrester J, Qu H, Yin L, Lai CJ, Bao R, Qian C. (2010) Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.. J Med Chem, 53 (5): (2000-9). [PMID:20143778] [10.1021/op500134e] |
7. Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R. (2016) Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.. Eur J Med Chem, 109 (13): (216-37). [PMID:26774927] [10.1021/op500134e] |
8. Ai T, Wilson DJ, More SS, Xie J, Chen L. (2016) 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.. J Med Chem, 59 (7): (2928-41). [PMID:26982234] [10.1021/op500134e] |
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10. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.. EMBO J, 23 (12): (2369-80). [PMID:15152190] [10.1021/op500134e] |
11. Antonello Mai,Sergio Valente,Sarah Meade,Vincenzo Carafa,Maria Tardugno,Angela Nebbioso,Andrea Galmozzi,Nico Mitro,Emma De Fabiani,Lucia Altucci,Aleksey Kazantsev. (2009-08-12) Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.. Journal of medicinal chemistry, 52 ((17)): (5496-5504). [PMID:19663498] |
12. Takayoshi Suzuki,Tomomi Asaba,Erika Imai,Hiroki Tsumoto,Hidehiko Nakagawa,Naoki Miyata. (2009-08-25) Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.. Bioorganic & medicinal chemistry letters, 19 ((19)): (5670-5672). [PMID:19700324] |
13. Jamin D Steffen,Donna L Coyle,Komath Damodaran,Paul Beroza,Myron K Jacobson. (2011-06-23) Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG).. Journal of medicinal chemistry, 54 ((15)): (5403-5413). [PMID:21692479] |
14. Yi-Pei Chen,Chad C Catbagan,Jeannette T Bowler,Trevor Gokey,Natalie D M Goodwin,Anton B Guliaev,Weiming Wu,Taro Amagata. (2013-11-26) Evaluation of benzoic acid derivatives as sirtuin inhibitors.. Bioorganic & medicinal chemistry letters, 24 ((1)): (349-352). [PMID:24269123] |
15. In Hye Lee,Liu Cao,Raul Mostoslavsky,David B Lombard,Jie Liu,Nicholas E Bruns,Maria Tsokos,Frederick W Alt,Toren Finkel. (2008-02-26) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.. Proceedings of the National Academy of Sciences of the United States of America, 105 ((9)): (3374-3379). [PMID:18296641] |
16. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed. (2009-05-06) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.. Analytical chemistry, 81 ((11)): (4493-4501). [PMID:19413330] |
17. Brandi D Sanders,Brittany Jackson,Michael Brent,Alexander M Taylor,Weiwei Dang,Shelley L Berger,Stuart L Schreiber,Konrad Howitz,Ronen Marmorstein. (2009-09-08) Identification and characterization of novel sirtuin inhibitor scaffolds.. Bioorganic & medicinal chemistry, 17 ((19)): (7031-7041). [PMID:19734050] |
18. Taki Sakai,Yotaro Matsumoto,Minoru Ishikawa,Kazuyuki Sugita,Yuichi Hashimoto,Nobuhiko Wakai,Akio Kitao,Era Morishita,Chikashi Toyoshima,Tomoatsu Hayashi,Tetsu Akiyama. (2014-12-18) Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.. Bioorganic & medicinal chemistry, 23 ((2)): (328-339). [PMID:25515955] |
19. Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L.. (2008) epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.. J Med Chem, 51 (7): (2279-2290). [PMID:18348515] [10.1021/jm701595q] |
20. Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB.. (2009) Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.. J Med Chem, 52 (5): (1275-1283). [PMID:19199480] [10.1021/jm8012954] |
21. Medda F, Russell RJ, Higgins M, McCarthy AR, Campbell J, Slawin AM, Lane DP, Lain S, Westwood NJ.. (2009) Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.. J Med Chem, 52 (9): (2673-2682). [PMID:19419202] [10.1021/jm8014298] |
22. Rotili D, Carafa V, Tarantino D, Botta G, Nebbioso A, Altucci L, Mai A.. (2011) Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.. Bioorg Med Chem, 19 (12): (3659-3668). [PMID:21306905] [10.1016/j.bmc.2011.01.025] |
23. Huber K, Superti-Furga G.. (2011) After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.. Bioorg Med Chem, 19 (12): (3616-3624). [PMID:21306906] [10.1016/j.bmc.2011.01.018] |
24. Hirsch BM, Hao Y, Li X, Wesdemiotis C, Wang Z, Zheng W.. (2011) A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK).. Bioorg Med Chem Lett, 21 (16): (4753-4757). [PMID:21752644] [10.1016/j.bmcl.2011.06.069] |
25. McCarthy AR, Pirrie L, Hollick JJ, Ronseaux S, Campbell J, Higgins M, Staples OD, Tran F, Slawin AM, Lain S, Westwood NJ.. (2012) Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.. Bioorg Med Chem, 20 (5): (1779-1793). [PMID:22304848] [10.1016/j.bmc.2012.01.001] |
26. Choi SH, Quinti L, Kazantsev AG, Silverman RB.. (2012) 3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2).. Bioorg Med Chem Lett, 22 (8): (2789-2793). [PMID:22446090] [10.1016/j.bmcl.2012.02.089] |
27. Suzuki T, Khan MN, Sawada H, Imai E, Itoh Y, Yamatsuta K, Tokuda N, Takeuchi J, Seko T, Nakagawa H, Miyata N.. (2012) Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.. J Med Chem, 55 (12): (5760-5773). [PMID:22642300] [10.1021/jm3002108] |
28. Fridén-Saxin M, Seifert T, Landergren MR, Suuronen T, Lahtela-Kakkonen M, Jarho EM, Luthman K.. (2012) Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.. J Med Chem, 55 (16): (7104-7113). [PMID:22746324] [10.1021/jm3005288] |
29. Rotili D, Tarantino D, Carafa V, Paolini C, Schemies J, Jung M, Botta G, Di Maro S, Novellino E, Steinkühler C, De Maria R, Gallinari P, Altucci L, Mai A.. (2012) Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.. J Med Chem, 55 (18): (8193-8197). [PMID:22931526] [10.1021/jm301115r] |
30. Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A.. (2012) Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.. J Med Chem, 55 (24): (10937-10947). [PMID:23189967] [10.1021/jm3011614] |
31. Amagata T, Xiao J, Chen YP, Holsopple N, Oliver AG, Gokey T, Guliaev AB, Minoura K.. (2012) Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.. J Nat Prod, 75 (12): (2193-2199). [PMID:23167691] [10.1021/np300640g] |
32. Salo HS, Laitinen T, Poso A, Jarho E, Lahtela-Kakkonen M.. (2013) Identification of novel SIRT3 inhibitor scaffolds by virtual screening.. Bioorg Med Chem Lett, 23 (10): (2990-2995). [PMID:23562596] [10.1016/j.bmcl.2013.03.033] |
33. Mellini P, Kokkola T, Suuronen T, Salo HS, Tolvanen L, Mai A, Lahtela-Kakkonen M, Jarho EM.. (2013) Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.. J Med Chem, 56 (17): (6681-6695). [PMID:23927550] [10.1021/jm400438k] |
34. Yoon YK, Ali MA, Wei AC, Choon TS, Osman H, Parang K, Shirazi AN.. (2014) Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.. Bioorg Med Chem, 22 (2): (703-710). [PMID:24387981] [10.1016/j.bmc.2013.12.029] |
35. Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A, Simon JA.. (2014) Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.. J Med Chem, 57 (8): (3283-3294). [PMID:24697269] [10.1021/jm4018064] |
36. Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB.. (2014) Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.. Eur J Med Chem, 76 (414-426). [PMID:24602787] [10.1016/j.ejmech.2014.02.003] |
37. Parenti MD, Grozio A, Bauer I, Galeno L, Damonte P, Millo E, Sociali G, Franceschi C, Ballestrero A, Bruzzone S, Del Rio A, Nencioni A.. (2014) Discovery of novel and selective SIRT6 inhibitors.. J Med Chem, 57 (11): (4796-4804). [PMID:24785705] [10.1021/jm500487d] |
38. Yoon YK, Ali MA, Wei AC, Shirazi AN, Parang K, Choon TS.. (2014) Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.. Eur J Med Chem, 83 (448-454). [PMID:24992072] [10.1016/j.ejmech.2014.06.060] |
39. Wu J, Li J, Xu MH, Liu D.. (2014) Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole.. Bioorg Med Chem Lett, 24 (14): (3050-3056). [PMID:24880902] [10.1016/j.bmcl.2014.05.028] |
40. Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB.. (2015) Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.. ACS Med Chem Lett, 6 (5): (607-611). [PMID:26005542] [10.1021/acsmedchemlett.5b00075] |
41. Zang W, Hao Y, Wang Z, Zheng W.. (2015) Novel thiourea-based sirtuin inhibitory warheads.. Bioorg Med Chem Lett, 25 (16): (3319-3324). [PMID:26081291] [10.1016/j.bmcl.2015.05.058] |
42. Sociali G, Galeno L, Parenti MD, Grozio A, Bauer I, Passalacqua M, Boero S, Donadini A, Millo E, Bellotti M, Sturla L, Damonte P, Puddu A, Ferroni C, Varchi G, Franceschi C, Ballestrero A, Poggi A, Bruzzone S, Nencioni A, Del Rio A.. (2015) Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.. Eur J Med Chem, 102 (530-539). [PMID:26310895] [10.1016/j.ejmech.2015.08.024] |
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44. Chen D, Zheng W.. (2016) Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine.. Bioorg Med Chem Lett, 26 (21): (5234-5239). [PMID:27707605] [10.1016/j.bmcl.2016.09.055] |
45. Kumar R, Nigam L, Singh AP, Singh K, Subbarao N, Dey S.. (2017) Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease.. Eur J Med Chem, 127 (909-916). [PMID:27836195] [10.1016/j.ejmech.2016.11.001] |
46. Lee HY, Nepali K, Huang FI, Chang CY, Lai MJ, Li YH, Huang HL, Yang CR, Liou JP.. (2018) (N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.. J Med Chem, 61 (3): (905-917). [PMID:29304284] [10.1021/acs.jmedchem.7b01404] |
47. Pirat C, Dacquet C, Leclerc V, Hennuyer N, Beucher-Gaudin M, Zanirato G, Géant A, Staels B, Ktorza A, Farce A, Caignard DH, Berthelot P, Lebegue N.. (2017) Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.. Eur J Med Chem, 137 (310-326). [PMID:28609708] [10.1016/j.ejmech.2017.06.006] |
48. Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB.. (2018) X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.. Eur J Med Chem, 155 (806-823). [PMID:29957526] [10.1016/j.ejmech.2018.06.041] |
49. Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S.. (2017) SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.. Bioorg Med Chem, 25 (20): (5849-5858). [PMID:28958848] [10.1016/j.bmc.2017.09.023] |
50. Atobe M, Yamakawa N, Wada Y, Goto T, Kawanishi M, Ito T, Saito M, Takeda M, Tabata T, Arai H.. (2017) A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators.. Bioorg Med Chem Lett, 27 (21): (4828-4831). [PMID:28988762] [10.1016/j.bmcl.2017.09.049] |
51. Hailu GS, Robaa D, Forgione M, Sippl W, Rotili D, Mai A.. (2017) Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.. J Med Chem, 60 (12): (4780-4804). [PMID:28241112] [10.1021/acs.jmedchem.6b01595] |
52. Kim MJ, An HJ, Kim DH, Lee B, Lee HJ, Ullah S, Kim SJ, Jeong HO, Moon KM, Lee EK, Yang J, Akter J, Chun P, Moon HR, Chung HY.. (2018) Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice.. Bioorg Med Chem Lett, 28 (4): (684-688). [PMID:29402742] [10.1016/j.bmcl.2018.01.021] |
53. Monaldi D, Rotili D, Lancelot J, Marek M, Wössner N, Lucidi A, Tomaselli D, Ramos-Morales E, Romier C, Pierce RJ, Mai A, Jung M.. (2019) Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2).. J Med Chem, 62 (19): (8733-8759). [PMID:31496251] [10.1021/acs.jmedchem.9b00638] |
54. Bouchet S, Linot C, Ruzic D, Agbaba D, Fouchaq B, Roche J, Nikolic K, Blanquart C, Bertrand P.. (2019) Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.. ACS Med Chem Lett, 10 (6): (863-868). [PMID:31223439] [10.1021/acsmedchemlett.8b00440] |
55. Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A.. (2016) 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.. J Med Chem, 59 (4): (1471-1491). [PMID:26689352] [10.1021/acs.jmedchem.5b01117] |
56. Gromek SM, deMayo JA, Maxwell AT, West AM, Pavlik CM, Zhao Z, Li J, Wiemer AJ, Zweifach A, Balunas MJ.. (2016) Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.. Bioorg Med Chem, 24 (21): (5183-5196). [PMID:27614919] [10.1016/j.bmc.2016.08.040] |
57. Farooqi AS, Hong JY, Cao J, Lu X, Price IR, Zhao Q, Kosciuk T, Yang M, Bai JJ, Lin H.. (2019) Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.. J Med Chem, 62 (8): (4131-4141). [PMID:30986062] [10.1021/acs.jmedchem.9b00191] |
58. Seifert T, Malo M, Kokkola T, Stéen EJL, Meinander K, Wallén EAA, Jarho EM, Luthman K.. (2020) A scaffold replacement approach towards new sirtuin 2 inhibitors.. Bioorg Med Chem, 28 (2): (115231-115231). [PMID:31848116] [10.1016/j.bmc.2019.115231] |
59. Sun W, Chen X, Huang S, Li W, Tian C, Yang S, Li L.. (2020) Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.. Bioorg Med Chem Lett, 30 (16): (127215-127215). [PMID:32631504] [10.1016/j.bmcl.2020.127215] |
60. Chen X, Sun W, Huang S, Zhang H, Lin G, Li H, Qiao J, Li L, Yang S.. (2020) Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.. J Med Chem, 63 (18): (10474-10495). [PMID:32787077] [10.1021/acs.jmedchem.0c01183] |
61. Wang XX,Wan RZ,Liu ZP. (2018) Recent advances in the discovery of potent and selective HDAC6 inhibitors.. Eur J Med Chem, 143 (1406-1418). [PMID:29133060] [10.1016/j.ejmech.2017.10.040] |
62. Yang LL,Wang HL,Yan YH,Liu S,Yu ZJ,Huang MY,Luo Y,Zheng X,Yu Y,Li GB. (2020) Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.. Eur J Med Chem, 192 (112201-112201). [PMID:32163813] [10.1016/j.ejmech.2020.112201] |
63. Yagci S,Gozelle M,Kaya SG,Ozkan Y,Aksel AB,Bakar-Ates F,Dundar Y,Eren G. (2021) Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT.. Bioorg Med Chem, 30 (115961-115961). [PMID:33360574] [10.1016/j.bmc.2020.115961] |
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86. Pedersen, Thomas A TA and 7 more authors.. (2007) Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.. The EMBO journal, (21): [PMID:17290224] |
87. Jeong, Jaemin J and 8 more authors.. (2007) SIRT1 promotes DNA repair activity and deacetylation of Ku70.. Experimental & molecular medicine, (28): [PMID:17334224] |
88. Dai, Yan Y and 5 more authors.. (2007) Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor.. Molecular endocrinology (Baltimore, Md.), [PMID:17505061] |
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90. Wong, Sharon S and Weber, Jason D JD.. (2007) Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1.. The Biochemical journal, (1): [PMID:17620057] |
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99. Murayama, Akiko A and 13 more authors.. (2008) Epigenetic control of rDNA loci in response to intracellular energy status.. Cell, (16): [PMID:18485871] |
100. Asher, Gad G and 8 more authors.. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation.. Cell, (25): [PMID:18662546] |
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104. Pediconi, Natalia N and 8 more authors.. (2009) hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage.. Molecular and cellular biology, [PMID:19188449] |
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107. Purushotham, Aparna A and 5 more authors.. (2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.. Cell metabolism, [PMID:19356714] |
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109. Xie, Yuan-Bin YB and 8 more authors.. (2009) Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.. The Journal of biological chemistry, (16): [PMID:19690166] |
110. Mayya, Viveka V and 7 more authors.. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.. Science signaling, (18): [PMID:19690332] |
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112. Nasrin, Nargis N and 6 more authors.. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.. PloS one, (22): [PMID:20027304] |
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121. Ponugoti, Bhaskar B and 9 more authors.. (2010) SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.. The Journal of biological chemistry, (29): [PMID:20817729] |
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124. Ming, Mei M and 6 more authors.. (2010) Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.. Proceedings of the National Academy of Sciences of the United States of America, (28): [PMID:21149730] |
125. Yuan, Fang F and 10 more authors.. (2011) MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.. The Journal of biological chemistry, (4): [PMID:21212262] |
126. Liu, Xiangyu X and 9 more authors.. (2011) Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:21245319] |
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129. Back, Jung Ho JH and 6 more authors.. (2011) Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.. The Journal of biological chemistry, (27): [PMID:21471201] |
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132. Marshall, Glenn M GM and 19 more authors.. (2011) SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.. PLoS genetics, [PMID:21698133] |
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138. Rizki, Gizem G and 7 more authors.. (2011) The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.. PLoS genetics, [PMID:21909281] |
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140. Oppenheimer, Hanna H and 8 more authors.. (2012) 75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes.. Arthritis and rheumatism, [PMID:21987377] |
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144. Dominy, John E JE and 15 more authors.. (2012) The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.. Molecular cell, (28): [PMID:23142079] |
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